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Mitral Annular Disjunction: Associated Pathologies and Clinical Consequences

  • Cardiac PET, CT, and MRI (P Cremer, Section Editor)
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Abstract

Purpose of Review

To provide an overview of mitral annular disjunction (MAD) and to discuss important challenges in diagnosis and management of MAD.

Recent Findings

MAD has regained interest in the context of sudden cardiac death (SCD) in patients with mitral valve prolapse (MVP), coined as the “arrhythmic” MVP syndrome. In addition, MAD in isolation was recently suggested to be associated with severe arrhythmia and SCD.

Summary

There is a lack of consensus on the definition of MAD and the imaging modality to be used for diagnosing MAD, and the therapeutic implications of MAD remain uncertain. Furthermore, the exact mechanism underlying the association of MAD with SCD remains largely unexplored.

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Papers of particular interest, published recently, have been highlighted as: •• Of major importance

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Funding

Dr. De Backer is supported as Senior Clinical Researcher by the Research Foundation–Flanders and by a grant for medical research from the Baillet Latour Funds.

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  1. Julie De Backer and Frank Timmermans contributed equally to the manuscript

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  1. Department of Cardiology, Ghent University Hospital, Corneel Heymanslaan 10, 9000, Ghent, Belgium

    Jonas Verbeke, Anthony Demolder, Julie De Backer & Frank Timmermans

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  1. Jonas Verbeke
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Verbeke, J., Demolder, A., De Backer, J. et al. Mitral Annular Disjunction: Associated Pathologies and Clinical Consequences. Curr Cardiol Rep 24, 1933–1944 (2022). https://doi.org/10.1007/s11886-022-01806-1

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