Abstract
Purpose of the Review
To review the current state of literature on sexual dysfunction in adults with congenital heart disease (ACHD).
Recent Findings
The prevalence of sexual dysfunction in ACHD is approximately 28%. Compared to age-matched cohorts, the prevalence of sexual dysfunction among ACHD cohorts demonstrates significant variability. ACHD have a lower rate of ever having sexual intercourse and often at a later age. Regardless of complexity, ACHD with sexual dysfunction have higher level of distress, decreased quality of life, and worse New York Heart Association classification. Patients, including heart failure and ACHD, treated with dual angiotensin receptor neprilysin inhibitor have reported improved sexual relationships.
Summary
The prevalence of sexual dysfunction in ACHD patients is high and sexual dysfunction research in ACHD remains limited. Therefore, the relationship between sexual dysfunction and ACHD remains ill-defined. Cardiologists that participate in the care of these patients should proactively discuss sexual health and provide counseling and therapies to provide high-quality healthcare for ACHD.
Similar content being viewed by others
Abbreviations
- ACHD:
-
Adult congenital heart disease
- CHD:
-
Congenital heart disease
- CVD:
-
Cardiovascular disease
- ED:
-
Erectile dysfunction
- FSFI:
-
Female Sexual Function Index
- NYHA:
-
New York Heart Association
- QOL:
-
Quality of life
- SHIM:
-
Sexual Health Inventory for Men
References
Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major Importance
Hoffman J, Kaplan S. The incidence of congenital heart disease. J Am Coll Cardiol. 2002;39(12):1890–900.
Hoffman J. Incidence of congenital heart disease: I. Postnatal incidence. Pediatr Cardiol. 1995;16:103–13.
Khairy P, Ionescu-Ittu R, Mackie AS, Abrahamowicz M, Pilote L, Marelli AJ. Changing mortality in congenital heart disease. J Am Coll Cardiol. 2010;56(14):1149–57. https://doi.org/10.1016/j.jacc.2010.03.085.
Marelli A, Ionescu-Ittu R, Mackie AS, Guo L, Dendukuri N, Kaouauch M. Lifetime prevalence of congenital heart disease in the general population from 2000 to 2010. Circulation. 2014;130:749–56. https://doi.org/10.1161/CIRCULATIONAHA.113.008396.
Gilboa S, Devine OJ, Kucik JE, Oster ME, Riehle-Colarusso T, Nembhard WN, et al. Congenital heart defects in the United States: estimating the magnitude of the affected population in 2010. Circulation. 2016;134:101–9. https://doi.org/10.1161/CIRCULATIONAHA.115.019307.
World Health Organization. Defining Sexual health: report of a technical consultation on sexual health, 28–31 January 2002, Geneva, Switzerland. Sexual health document series. 2002:p4.
NIH Consensus Conference. Impotence. NIH Consensus Development Panel on Impotence. JAMA. 1993;270:83–90.
Mongra M, Bettencourt R, Barrett-Connor E. Community-based study of erectile dysfunction and sildenafil use: the Rancho Bernardo Study. Urology. 2002;59:753–7.
Burri A, Hilpert R, Spector T. Longitudinal evaluation of sexual function in a cohort of pre- and postmenopausal women. J Sex Med. 2015;12(6):1427–35. https://doi.org/10.1111/jsm.12893.
Seidl A, Bullough B, Haughey B. Understanding the effects of a myocardial infarction on sexual functioning: a basis for sexual counseling. Rehabil Nurs. 1991;16:255–64.
McVary KT. Erectile dysfunction. NEJM. 2007;357:2472–81. https://doi.org/10.1056/NEJMcp067261.
Drory Y, Kravetz S, Weingarten M. Comparison of sexual activity of women and men after a first acute myocardial infarction. Am J Cardiol. 2000;85:1283–7.
Vlachopoulos C, Loakeimidis N, Terentes-Printzios D, Stefanadis C. The triad: erectile dysfunction - endothelial dysfunction - cardiovascular disease. Curr Pharm Des. 2008;14:3700–37714.
Shin D, Pregenzer G, Gardin JM. Erectile dysfunction: a disease marker for cardiovascular disease. Cardiol Rev. 2011;19:5–11. https://doi.org/10.1097/CRD.0b013e3181fb7eb8.
Solomon H, Man JW, Wierzbicki AS, Jackson G. Relation of erectile dysfuntion to angiographic coronary artery disease. Am J Cardiol. 2003;91:230–1.
Kaya C, Yilmaz G, Nurkalem Z, Ilktac A, Karaman M. Sexual function in women with coronary artery disease: a preliminary study. Int J Impot Res. 2007;19:326Y9.
Traeen T, Olsen S. Sexual dysfunction and sexual well being in people with heart disease. Sexual and Relationship Therapy. 2007;22(2):193–208.
Steinke EE. Sexual dysfunction in women with cardiovascular disease: what do we know? J Cardiovasc Nurs. 2010;25(2):151–8.
Jaarsma T, Dracup K, Walden J, Stevenson L. Sexual function in patients with advanced heart failure. Heart Lung. 1996;25:262–70.
Jaarsma T. Sexual problems in heart failure patients. Eur J Cardiovasc Nurs. 2002;1:61–7.
Uddin S, Mirbolouk M, Dardari Z, Feldman DI, Cainzos-Achirica M, AP DF, et al. Erectile dysfunction as an independent predictor of future cardiovascular events: the multi-ethnic study of atherosclerosis. Circulation. 2018;138(2) https://doi.org/10.1161/CIRCULATIONAHA.118.033990. This study provided the most up-to-date analysis of a large, modern, and multi-ethnic cohort with 3.8 years of follow-up that demonstrated that ED is an independent predictor of future cardiovascular disease events.
Moons P, Van Deyk K, Marquet K, De Bleser L, Budts W, De Geest S. Sexual functioning and congenital heart disease: something to worry about? Int J Cardiol. 2007;121:30–5. https://doi.org/10.1016/j.ijcard.2006.10.020.
Winter M, Reisma C, Kedde H, Bouma BJ, Vis JC, Luijendijk P, et al. Sexuality in adult patients with congenital heart disease and their partners. Am J Cardiol. 2010;106:1164–8. https://doi.org/10.1016/j.amjcard.2010.06.027.
Vigl M, Hager A, Bauer U, Niggemeyer E, Wittstock B, Köhn F-M, et al. Sexuality and subjective wellbeing in male patients with congenital heart disease. Heart. 2009;95:1179–83. https://doi.org/10.1136/hrt.2008.156695.
Neiman A, Ginde S, Earing MG, Bartz PJ, Cohen S. The prevalence of sexual dysfunction and its association with quality of life in adults with congenital heart disease. Int J Cardiol. 2017;228:953–7. https://doi.org/10.1016/j.ijcard.2016.11.192. This study demonstrated sexual dysfunction is highly prevalent in a cohort of well-functioning young adults with congenital heart disease and is associated with worse health-related quality of life. Potential risk factors for sexual dysfunction in this population were also identified.
Cook S, Valente AM, Maul TM, Dew MA, Hickey J, Burger J, et al. Shock-related anxiety and sexual function in adults with congenital heart disease and implantable cardioverter- defibrillators. Heart Rhtyhm. 2013;10:805–10. https://doi.org/10.1016/j.hrthm.2013.02.016. This is the only prospective, multicenter, cross-sectional study conducted in adults with congenital heart disease and implantable cardioverter-defibrillators that demonstrated a high level of shock-related anxiety and its association with sexual dysfunction in this population.
Fry K, Gerhardt CA, Ash J, Zaidi AN, Garg V, McBride KL, et al. Lifetime prevalence of sexual intercourse and contraception use at last sex among adolescents and young adults with congenital heart disease. J Adolesc Health. 2015;56:396–401. https://doi.org/10.1016/j.jadohealth.2014.12.013.
Cook S, Arnott LM, Nicholson LM, Cook LR, Sparks EA, Daniels CJ. Erectile dysfunction in men with congenital heart disease. Am J Cardiol. 2008;102:1728–30. https://doi.org/10.1016/j.amjcard.2008.08.017.
Freitas I, Castro M, Sarmento SL, Moura C, Viana V, Areias JC, et al. A cohort study on psychosocial adjustment and psychopathology in adolescents and young adults with congenital heart disease. BMJ Open. 2012;3:e001138. https://doi.org/10.1136/bmjopen-2012-001138.
Opic P, Roos-Hesselink JW, Cuypers JA, Witsenburg M, van den Bosch A, van Domburg RT, et al. Sexual functioning is impaired in adults with congenital heart disease. Int J Cardiol. 2013;168:3872–7. https://doi.org/10.1016/j.ijcard.2013.06.029. A large prospective trials conducted in adults with congenital heart disease with 30–43 years of follow-up after cardiac surgery. It demonstrated that sexual function is significanlly impaired in adults with congenital heart disease and suggested the importance of systematic follow-up of sexual function in this population.
Mialon A, Berchtold A, Michaud PA, Gmel G, Suris JC. Sexual dysfunctions among young men: prevalence and associated factors. J Ado Health. 2012;51(1):25–31. https://doi.org/10.1016/j.jadohealth.2012.01.008.
Kuhl E, Dixit NK, Walker RL, Conti JB, Sears SF. Measurement of patient fears about implantable cardioverter-defibrillator shock: an initial evaluation of the Florida shock anxiety scale. Pacing Clin Electrophysiol. 2006;29:614–81.
Papez A. Psychological well-being and sexual function in adults with congenital heart disease: not tonight, dear, I have an ICD. Heart Rhtyhm Society. 2013;10(6):811–2. https://doi.org/10.1016/j.hrthm.2013.03.004.
Baumhäkel M, Schlimmer N, Kratz M, Hackett G, Jackson G, Böhm M. Cardiovascular risk, drugs and erectile function: a systematic analysis. Int J Clin Pract. 2011;65:289–98.
Chandra A, Lewis EF, Claggett BL. Effects of sacubitril/valsartan on physical and social activity limitations in patients with heart failure: a secondary analysis of the PARADIGM-HF trial. JAMA Cardiol. 2018; published online April 4, 2018; https://doi.org/10.1001/jamacardio.2018.0398. This study utilized data from a large, randomized, double-blind, active treatment-controlled clinical trial and provided secondary analysis that demonstrated improved physical and social actitivies in heart failure patients treated with ARNi, with the largest improvement seen in sexual relationships.
Wayman C, Baxter D, Turner L, Van Der Graaf PH, Naylor AM. UK-414,495, a selective inhibitor of neutral endopeptidase, potentiates pelvic nerve-stimulated increases in female genital blood flow in the anaesthetized rabbit. Br J Pharmacol. 2010;16:51–9. https://doi.org/10.1111/j.1476-5381.2010.00691.x.
Pryde D, Cook AS, Burring DJ, Jones LH, Foll S, Platts MY, et al. Novel selective inhibitors of neutral endopeptidase for the treatment of female sexual arousal disorder. Bioorg Med Chem. 2007;15(1):142–59. https://doi.org/10.1016/j.bmc.2006.10.002.
McMurray JJV, Packer M, Desai AS. Angiotensin–neprilysin inhibition versus enalapril in heart failure. N Engl J Med. 2014;371:993–1004. https://doi.org/10.1056/NEJMoa1409077.
Pradat P. Recurrence risk for major congenital heart defects in Sweden: a registry study. Genet Epidemiol. 1994;11(2):131–40. https://doi.org/10.1002/gepi.1370110204.
Nicolai M, Both S, Liem SS, RCM P, Putter H, Schalij MJ, et al. Discussing sexual function in the cardiology practice. Clin Res Cardiol. 2013;102:329–36. https://doi.org/10.1007/s00392-013-0549-2.
Nicolai M, van Bavel J, Somsen GA, de Grooth GJ, Tulevski II, Lorsheyd A, et al. Erectile dysfunction in the cardiology practice—a patients’ perspective. Am Heart J. 2014;167:178–85.
Jaarsma T, Steinke EE, Gianotten WL. Sexual problems in cardiac patients: how to assess, when to refer. J Cardiovasc Nurs. 2010;25(2):159–64. This review provided various approaches as well as reliable and validated tools available for health-care providers to help faciliate discussions about sexual concerns or identify sexual dysfunction in patients with cardiovascular disease.
Levine GM, Steinke EE, Bakaeen FG, Bozkurt B, Cheitlin MD, Conti JB, et al. Sexual activity and cardiovascular disease: a scientific statement from the American Heart Association. Circulation. 2012;125:1058–72. https://doi.org/10.1161/CIR.0b013e3182447787.
Takken T, Giardini A, Reybrouck T, Gewillig M, Hovels-Gurich HH, Longmuir PE, et al. Recommendations for physical activity, recreation sport, and exercise training in paediatric patients with congenital heart disease: a report from the Exercise, Basic & Translational Research Section of the European Association of Cardiovascular Prevention and Rehabilitation, the European Congenital Heart and Lung Exercise Group, and the Association for European Paediatric Cardiology. Eur J Prevent Cardiol. 2012;19:1034–65. https://doi.org/10.1177/1741826711420000.
Steinke E, Jaarsma T, Barnason SA, Byrne M, Doherty S, Dougherty CM, et al. Sexual counselling for individuals with cardiovascular disease and their partner: a consensus document from the American Heart Association and the ESC Council on Cardiovascular Nursing and Allied Professions (CCNAP). Eur Heart J. 2013;34:3217–35. https://doi.org/10.1093/eurheartj/eht270.
Annon J. The behavioural treatment of sexual problems. Brief Therapy. 1974;1
Afilalo J, Therrien J, Pilote L, Ionescu-Ittu R, Martucci G, Marelli AJ. Geriatric congenital heart diease. J Am Coll Cardiol. 2011;58(14):1509–15.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of Interest
Sihong Huang and Stephen C. Cook declare that they have no conflict of interest.
Human and Animal Rights and Informed Consent
This article does not contain any studies with human or animal subjects performed by any of the authors.
Additional information
This article is part of the Topical Collection on Congenital Heart Disease
Rights and permissions
About this article
Cite this article
Huang, S., Cook, S.C. It Is Not Taboo: Addressing Sexual Function in Adults with Congenital Heart Disease. Curr Cardiol Rep 20, 93 (2018). https://doi.org/10.1007/s11886-018-1029-0
Published:
DOI: https://doi.org/10.1007/s11886-018-1029-0