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Large-Scale Genomic Biobanks and Cardiovascular Disease

  • Aeron M. Small
  • Christopher J. O’Donnell
  • Scott M. Damrauer
Cardiovascular Genomics (TL Assimes, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Cardiovascular Genomics

Abstract

Purpose of review

Cardiovascular disease is a leading cause of morbidity and mortality worldwide and is the focus of extensive biomedical research. Large genetic consortia combining data from many traditional prospective cohort and ascertained case-control study designs have facilitated the discovery of genetic associations for a variety of cardiovascular diseases including diabetes, coronary artery disease, and hypertension. Biobank-based genetic studies offer an alternative whereby large populations are genotyped and linked to electronic health records.

Recent findings

Biobank sample sizes worldwide have surpassed even the largest genetic consortia and have yielded key insights into the genetic determinants of both common and rare cardiovascular phenotypes.

Summary

Herein, we provide an overview of the largest genomic biobanks and discuss the relevant advantages and challenges inherent to the biobank model of cohort generation and genomic study design.

Keywords

Biobanks Cardiovascular disease Genetics 

Notes

Compliance with Ethical Standards

Conflict of Interest

Aeron M. Small, Christopher J. O’Donnell, and Scott M. Damrauer declare that they have no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Copyright information

© This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2018

Authors and Affiliations

  • Aeron M. Small
    • 1
  • Christopher J. O’Donnell
    • 2
    • 3
    • 4
  • Scott M. Damrauer
    • 5
    • 6
    • 7
  1. 1.Department of Medicine, Yale New Haven HospitalYale University School of MedicineNew HavenUSA
  2. 2.Cardiology Section, Department of Medicine, Veterans Affairs Boston Healthcare SystemBostonUSA
  3. 3.Cardiovascular Medicine Division, Department of Medicine, Brigham and Women’s HospitalHarvard Medical SchoolBostonUSA
  4. 4.Million Veteran Program, Department of Veteran’s AffairsWashingtonUSA
  5. 5.Corporal Michael Crescenz VA Medical CenterPhiladelphiaUSA
  6. 6.Perlman School of MedicineUniversity of PennsylvaniaPhiladelphiaUSA
  7. 7.Hospital of the University of PennsylvaniaPhiladelphiaUSA

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