Skip to main content

Advertisement

Log in

Improving Medication Adherence in Coronary Heart Disease

  • Psychological Aspects of Cardiovascular Diseases (A Steptoe, Section Editor)
  • Published:
Current Cardiology Reports Aims and scope Submit manuscript

Abstract

Purpose of Review

The purpose of this review was to synthesize research findings from recently published randomized controlled trials (RCTs) targeting any phase of medication adherence, from initiation to discontinuation, among patients with coronary heart disease (CHD).

Recent Findings

We identified successful strategies and promising practices for improving medication adherence among patients diagnosed with CHD. Consistent intervention strategies included the following: (1) facilitating patient-provider communication, (2) using mHealth technologies with emphasis on two-way communication, (3) providing patient education in tandem with lifestyle and behavioral counseling, and (4) providing psychosocial support. Regarding medication adherence phases, all studies examined implementation (i.e., taking medications as prescribed over time) and one also addressed treatment initiation (i.e., beginning a new medication). None identified addressed discontinuation. Studies varied by use of objective, self-report, and a combination of outcome measures with a greater number reporting only subjective measures of adherence. Key findings remained mixed in supporting specific intervention designs or delivery formats.

Summary

This review addresses available data of promising practices for improving CHD medication adherence. Future studies are needed to examine intervention effectiveness, scalability, and durability of observed outcome effects.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Subscribe and save

Springer+ Basic
EUR 32.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or Ebook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

Abbreviations

ACE:

Angiotensin converting enzyme inhibitors

CHD:

Coronary heart disease

MEMS:

Medication Event Monitoring System

mHealth:

Mobile health

MI:

Myocardial infarction

MMAS:

Morisky Medication Adherence Scale

PCI:

Percutaneous coronary intervention

RCT:

Randomized controlled trial

SMS:

short message service or text message

References

Papers of particular interest, published recently, have been highlighted as:• Of importance •• Of major importance

  1. Sabaté E. Adherence to long-term therapies: evidence for action. Geneva: World Health Organization; 2003.

    Google Scholar 

  2. Benjamin EJ, Blaha MJ, Chiuve SE, Cushman M, Das SR, Deo R, et al. Heart disease and stroke Statistics-2017 update: a report from the American Heart Association. Circulation. 2017;135(10):e146–603.

    Article  PubMed  PubMed Central  Google Scholar 

  3. World Health Organization. Preventing chronic diseases: a vital investment. Geneva: World Health Organization; 2005.

    Google Scholar 

  4. Bitton A, Choudhry NK, Matlin OS, Swanton K, Shrank WH. The impact of medication adherence on coronary artery disease costs and outcomes: a systematic review. Am J Med. 2013;126(4):357.e7-.e27.

    Article  Google Scholar 

  5. Dunbar-Jacob J, Bohachick P, Mortimer MK, Sereika SM, Foley SM. Medication adherence in persons with cardiovascular disease. J Cardiovasc Nurs. 2003;18(3):209–18.

    Article  PubMed  Google Scholar 

  6. Ho PM, Magid DJ, Shetterly SM, Olson KL, Maddox TM, Peterson PN, et al. Medication nonadherence is associated with a broad range of adverse outcomes in patients with coronary artery disease. Am Heart J. 2008;155(4):772–9.

    Article  PubMed  Google Scholar 

  7. Ho PM, Bryson CL, Rumsfeld JS. Medication adherence: its importance in cardiovascular outcomes. Circulation. 2009;119(23):3028–35.

    Article  PubMed  Google Scholar 

  8. Vrijens B, De Geest S, Hughes DA, Przemyslaw K, Demonceau J, Ruppar T, et al. A new taxonomy for describing and defining adherence to medications. Br J Clin Pharmacol. 2012;73(5):691–705.

    Article  PubMed  PubMed Central  Google Scholar 

  9. Roth GA, Morden NE, Zhou W, Malenka DJ, Skinner J. Clopidogrel use and early outcomes among older patients receiving a drug-eluting coronary artery stent. Circ Cardiovasc Qual Outcomes. 2012;5(1):103–12.

    Article  PubMed  Google Scholar 

  10. Mann DM, Allegrante JP, Natarajan S, Halm EA, Charlson M. Predictors of adherence to statins for primary prevention. Cardiovasc Drugs Ther. 2007;21(4):311–6.

    Article  PubMed  Google Scholar 

  11. Ho PM, Spertus JA, Masoudi FA, Reid KJ, Peterson ED, Magid DJ, et al. Impact of medication therapy discontinuation on mortality after myocardial infarction. Arch Intern Med. 2006;166(17):1842–7.

    Article  PubMed  Google Scholar 

  12. Kramer JM, Hammill B, Anstrom KJ, Fetterolf D, Snyder R, Charde JP, et al. National evaluation of adherence to beta-blocker therapy for 1 year after acute myocardial infarction in patients with commercial health insurance. Am Heart J. 2006;152(3):454.e1-8.

    Article  PubMed  CAS  Google Scholar 

  13. Melnikow J, Kiefe C. Patient compliance and medical research: issues in methodology. J Gen Intern Med. 1994;9(2):96–105.

    Article  CAS  PubMed  Google Scholar 

  14. Gellad WF, Grenard JL, Marcum ZA. A systematic review of barriers to medication adherence in the elderly: looking beyond cost and regimen complexity. Am J Geriatr Pharmacother. 2011;9(1):11–23.

    Article  PubMed  PubMed Central  Google Scholar 

  15. Schmittdiel JA, Nichols GA, Dyer W, Steiner JF, Karter AJ, Raebel MA. Health care system-level factors associated with performance on Medicare STAR adherence metrics in a large, integrated delivery system. Med Care. 2015;53(4):332–7.

    PubMed  PubMed Central  Google Scholar 

  16. Demonceau J, Ruppar T, Kristanto P, Hughes DA, Fargher E, Kardas P, et al. Identification and assessment of adherence-enhancing interventions in studies assessing medication adherence through electronically compiled drug dosing histories: a systematic literature review and meta-analysis. Drugs. 2013;73(6):545–62.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  17. Mistry N, Keepanasseril A, Wilczynski NL, Nieuwlaat R, Ravall M, Haynes RB. Technology-mediated interventions for enhancing medication adherence. J Am Med Inform Assoc: JAMIA. 2015;22(e1):e177–93.

    Article  PubMed  Google Scholar 

  18. •• Nieuwlaat R, Wilczynski N, Navarro T, Hobson N, Jeffery R, Keepanasseril A, et al. Interventions for enhancing medication adherence. Cochrane Database Syst Rev. 2014(11) https://doi.org/10.1002/14651858. This study reports findings from a sysetmatic review to assess the effects of interventions thtat improve both medication adherence and relevant clinical outcomes.

  19. •• van Driel ML, Morledge MD, Ulep R, Shaffer JP, Davies P, Deichmann R. Interventions to improve adherence to lipid-lowering medication. Cochrane Database Syst Rev. 2016;12:Cd004371. This study reports findings from a systematic review to assess the effects of interventions aimed at improving adherence to lipid-lowering medications and associated clinical outcomes.

    PubMed  Google Scholar 

  20. Al-Foraih M, Somerset S. Factors affecting adherence to statins in Hypercholesterolemic Kuwaiti patients: a cross-sectional study. Med Princ Pract: Int J Kuwait Univ, Health Sci Cent. 2017;26(1):35–40.

    Article  Google Scholar 

  21. Alsabbagh MW, Lix LM, Eurich D, Wilson TW, Blackburn DF. Multiple-domain versus single-domain measurements of socioeconomic status (SES) for predicting nonadherence to statin medications: an observational population-based cohort study. Med Care. 2016;54(2):195–204.

    Article  PubMed  Google Scholar 

  22. Ammenwerth E, Woess S, Baumgartner C, Fetz B, van der Heidt A, Kastner P, et al. Evaluation of an integrated Telemonitoring surveillance system in patients with coronary heart disease. Methods Inf Med. 2015;54(5):388–97.

    Article  CAS  PubMed  Google Scholar 

  23. Aspry KE, Furman R, Karalis DG, Jacobson TA, Zhang AM, Liptak GS, et al. Effect of health information technology interventions on lipid management in clinical practice: a systematic review of randomized controlled trials. J Clin Lipidol. 2013;7(6):546–60.

    Article  PubMed  Google Scholar 

  24. Ayala C, Fang J, Yuan K. Prevalence of taking actions to control blood pressure among adults with self-reported hypertension in 18 states and the District of Columbia, 2009. J Clin Hypertens (Greenwich, Conn). 2015;17(3):172–82.

    Article  Google Scholar 

  25. Banerjee A, Khandelwal S, Nambiar L, Saxena M, Peck V, Moniruzzaman M, et al. Health system barriers and facilitators to medication adherence for the secondary prevention of cardiovascular disease: a systematic review. Open Heart. 2016;3(2):e000438.

    Article  PubMed  PubMed Central  Google Scholar 

  26. Barker-Collo S, Krishnamurthi R, Witt E, Feigin V, Jones A, McPherson K, et al. Improving adherence to secondary stroke prevention strategies through motivational interviewing: randomized controlled trial. Stroke. 2015;46(12):3451–8.

    Article  PubMed  Google Scholar 

  27. Berkowitz SA, Seligman HK, Choudhry NK. Treat or eat: food insecurity, cost-related medication underuse, and unmet needs. Am J Med. 2014;127(4):303-10.e3.

    Article  Google Scholar 

  28. Cai H, Dai H, Hu Y, Yan X, Xu H. Pharmacist care and the management of coronary heart disease: a systematic review of randomized controlled trials. BMC Health Serv Res. 2013;13:461.

    Article  PubMed  PubMed Central  Google Scholar 

  29. Campbell DJ, Tonelli M, Hemmelgarn B, Mitchell C, Tsuyuki R, Ivers N, et al. Assessing outcomes of enhanced chronic disease care through patient education and a value-based formulary study (ACCESS)-study protocol for a 2x2 factorial randomized trial. Implement Sci: IS. 2016;11(1):131.

    Article  PubMed  PubMed Central  Google Scholar 

  30. Cao XY, Tian L, Chen L, Jiang XL. Effects of a hospital-community partnership transitional program in patients with coronary heart disease in Chengdu, China: A randomized controlled trial. Jpn J Nurs Sci: JJNS. 2017 https://doi.org/10.1111/jjns.12160.

  31. Chatelin J, Stathopoulou MG, Arguinano AA, Xie T, Visvikis-Siest S. Pharmacogenomic challenges in cardiovascular diseases: examples of drugs and considerations for future integration in clinical practice. Curr Pharm Biotechnol 2017;18(3):231–41.

  32. Chen S, Gong E, Kazi DS, Gates AB, Karaye KM, Girerd N, et al. Development of a mobile phone-based intervention to improve adherence to secondary prevention of coronary heart disease in China. J Med Eng Technol. 2016;40(7–8):372–82.

    Article  PubMed  Google Scholar 

  33. Cheng HM, Chiang CE, Chen CH. The novelty of the 2015 guidelines of the Taiwan Society of Cardiology and the Taiwan hypertension Society for the Management of hypertension. Pulse (Basel, Switzerland). 2015;3(1):29–34.

    Google Scholar 

  34. Chowdhury R, Khan H, Heydon E, Shroufi A, Fahimi S, Moore C, et al. Adherence to cardiovascular therapy: a meta-analysis of prevalence and clinical consequences. Eur Heart J. 2013;34(38):2940–8.

    Article  CAS  PubMed  Google Scholar 

  35. Dale LP, Whittaker R, Jiang Y, Stewart R, Rolleston A, Maddison R. Improving coronary heart disease self-management using mobile technologies (Text4Heart): a randomised controlled trial protocol. Trials. 2014;15:71.

    Article  PubMed  PubMed Central  Google Scholar 

  36. Davies AK, McGale N, Humphries SE, Hirani SP, Beaney KE, Bappa DA, et al. Effectiveness of a self-management intervention with personalised genetic and lifestyle-related risk information on coronary heart disease and diabetes-related risk in type 2 diabetes (CoRDia): study protocol for a randomised controlled trial. Trials. 2015;16:547.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  37. Devi R, Singh SJ, Powell J, Fulton EA, Igbinedion E, Rees K. Internet-based interventions for the secondary prevention of coronary heart disease. Cochrane Database Syst Rev. 2015;(12) https://doi.org/10.1002/14651858.

  38. Everett B, Salamonson Y, Rolley JX, Davidson PM. Underestimation of risk perception in patients at risk of heart disease. Eur J Cardiovasc Nurs: J Work Group Cardiovasc Nurs Eur Soc Cardiol. 2016;15(3):e2–9.

    Article  Google Scholar 

  39. Fang R, Li X. Electronic messaging support service programs improve adherence to lipid-lowering therapy among outpatients with coronary artery disease: an exploratory randomised control study. J Clin Nurs. 2016;25(5–6):664–71.

    Article  PubMed  Google Scholar 

  40. Gaisenok O, Martsevich S, Tripkosh S, Lukina Y. Analysis of lipid-lowering therapy and factors affecting regularity of statin intake in patients with cardiovascular disease enrolled in the PROFILE registry. Rev Port Cardiol: Orgao Oficial Soc Port Cardiol = Port J Cardiol: Off J Port Soc Cardiol. 2015;34(2):111–6.

    Google Scholar 

  41. Galema-Boers JM, Lenzen MJ, van Domburg RT, Roeters van Lennep J, van Bruchem-van de Scheur GG, Sijbrands EJ, et al. Predicting non-adherence in patients with familial hypercholesterolemia. Eur J Clin Pharmacol. 2014;70(4):391–7.

    Article  CAS  PubMed  Google Scholar 

  42. Goss F, Brachmann J, Hamm CW, Haerer W, Reifart N, Levenson B. High adherence to therapy and low cardiac mortality and morbidity in patients after acute coronary syndrome systematically managed by office-based cardiologists in Germany: 1-year outcomes of the ProAcor study. Vasc Health Risk Manag. 2017;13:127–37.

    Article  PubMed  PubMed Central  Google Scholar 

  43. Gu D, He J, Coxson PG, Rasmussen PW, Huang C, Thanataveerat A, et al. The cost-effectiveness of low-cost essential antihypertensive medicines for hypertension control in China: a modelling study. PLoS Med. 2015;12(8):e1001860.

    Article  PubMed  PubMed Central  Google Scholar 

  44. Gunnell AS, Knuiman MW, Geelhoed E, Hobbs MS, Katzenellenbogen JM, Hung J, et al. Long-term use and cost-effectiveness of secondary prevention drugs for heart disease in western Australian seniors (WAMACH): a study protocol. BMJ Open. 2014;4(9):e006258.

    Article  PubMed  PubMed Central  Google Scholar 

  45. Irvin MR, Shimbo D, Mann DM, Reynolds K, Krousel-Wood M, Limdi NA, et al. Prevalence and correlates of low medication adherence in apparent treatment-resistant hypertension. J Clin Hypertens (Greenwich, Conn). 2012;14(10):694–700.

    Article  Google Scholar 

  46. Kalia NK, Cespedes L, Youssef G, Li D, Budoff MJ. Motivational effects of coronary artery calcium scores on statin adherence and weight loss. Coron Artery Dis. 2015;26(3):225–30.

    Article  PubMed  Google Scholar 

  47. Kamath DY, Xavier D, Gupta R, Devereaux PJ, Sigamani A, Hussain T, et al. Rationale and design of a randomized controlled trial evaluating community health worker-based interventions for the secondary prevention of acute coronary syndromes in India (SPREAD). Am Heart J. 2014;168(5):690–7.

    Article  PubMed  PubMed Central  Google Scholar 

  48. Kang JH, Nguyen QN, Mutka J, Le QA. Rechallenging statin therapy in veterans with statin-induced myopathy post vitamin D replenishment. J Pharm Pract. 2016 https://doi.org/10.1177/0897190016674407.

  49. Keyserling TC, Sheridan SL, Draeger LB, Finkelstein EA, Gizlice Z, Kruger E, et al. A comparison of live counseling with a web-based lifestyle and medication intervention to reduce coronary heart disease risk: a randomized clinical trial. JAMA Intern Med. 2014;174(7):1144–57.

    Article  PubMed  PubMed Central  Google Scholar 

  50. Kim HY, Lee JA, Kim YS, Sunwoo S, Oh HJ, Kim CS, et al. Factors of compliance in patients with hypercholesterolemia using rosuvastatin in primary care. Korean J Fam Med. 2012;33(5):253–61.

    Article  PubMed  PubMed Central  Google Scholar 

  51. Kim S, Shin DW, Yun JM, Hwang Y, Park SK, Ko YJ, et al. Medication adherence and the risk of cardiovascular mortality and hospitalization among patients with newly prescribed antihypertensive medications. Hypertension (Dallas, Tex : 1979). 2016;67(3):506–12.

    CAS  Google Scholar 

  52. Kreibig SD, Whooley MA, Gross JJ. Social integration and mortality in patients with coronary heart disease: findings from the heart and soul study. Psychosom Med. 2014;76(8):659–68.

    Article  PubMed  PubMed Central  Google Scholar 

  53. Kripalani S, Schmotzer B, Jacobson TA. Improving medication adherence through graphically enhanced interventions in coronary heart disease (IMAGE-CHD): a randomized controlled trial. J Gen Intern Med. 2012;27(12):1609–17.

    Article  PubMed  PubMed Central  Google Scholar 

  54. Kronish IM, Lynch AI, Oparil S, Whittle J, Davis BR, Simpson LM, et al. The association between antihypertensive medication nonadherence and visit-to-visit variability of blood pressure: findings from the antihypertensive and lipid-lowering treatment to prevent heart attack trial. Hypertension (Dallas, Tex : 1979). 2016;68(1):39–45.

    Article  CAS  Google Scholar 

  55. Kunutsor SK, Seidu S, Khunti K. Aspirin for primary prevention of cardiovascular and all-cause mortality events in diabetes: updated meta-analysis of randomized controlled trials. Diabet Med: J Br Diabet Assoc. 2017;34(3):316–27.

    Article  CAS  Google Scholar 

  56. Lee WL, Abdullah KL, Bulgiba AM, Zainal AI. Prevalence and predictors of patient adherence to health recommendations after acute coronary syndrome: data for targeted interventions? Eur J Cardiovasc Nurs: J Work Group Cardiovasc Nurs Eur Soc Cardiol. 2013;12(6):512–20.

    Article  Google Scholar 

  57. Liberato AC, Rodrigues RC, Sao-Joao TM, Alexandre NM, Gallani MC. Satisfaction with medication in coronary disease treatment: psychometrics of the treatment satisfaction questionnaire for medication. Rev Lat Am Enfermagem. 2016 https://doi.org/10.1590/15188345.0745.2705.

  58. Librero J, Sanfelix-Gimeno G, Peiro S. Medication adherence patterns after hospitalization for coronary heart disease. A population-based study using electronic records and group-based trajectory models. PLoS One. 2016;11(8):e0161381.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  59. Lin EH, Von Korff M, Ciechanowski P, Peterson D, Ludman EJ, Rutter CM, et al. Treatment adjustment and medication adherence for complex patients with diabetes, heart disease, and depression: a randomized controlled trial. Ann Fam Med. 2012;10(1):6–14.

    Article  PubMed  PubMed Central  Google Scholar 

  60. Ludt S, Wensing M, Campbell SM, Ose D, van Lieshout J, Rochon J, et al. The challenge of cardiovascular prevention in primary care: implications of a European observational study in 8928 patients at different risk levels. Eur J Prev Cardiol. 2014;21(2):203–13.

    Article  PubMed  Google Scholar 

  61. Malik S, Billimek J, Greenfield S, Sorkin DH, Ngo-Metzger Q, Kaplan SH. Patient complexity and risk factor control among multimorbid patients with type 2 diabetes: results from the R2D2C2 study. Med Care. 2013;51(2):180–5.

    Article  PubMed  PubMed Central  Google Scholar 

  62. Marcum ZA, Zheng Y, Perera S, Strotmeyer E, Newman AB, Simonsick EM, et al. Prevalence and correlates of self-reported medication non-adherence among older adults with coronary heart disease, diabetes mellitus, and/or hypertension. Res Social Adm Pharm: RSAP. 2013;9(6):817–27.

    Article  PubMed  Google Scholar 

  63. Martin SS, Sperling LS, Blaha MJ, Wilson PW, Gluckman TJ, Blumenthal RS, et al. Clinician-patient risk discussion for atherosclerotic cardiovascular disease prevention: importance to implementation of the 2013 ACC/AHA guidelines. J Am Coll Cardiol. 2015;65(13):1361–8.

    Article  PubMed  PubMed Central  Google Scholar 

  64. Meng K, Seekatz B, Haug G, Mosler G, Schwaab B, Worringen U, et al. Evaluation of a standardized patient education program for inpatient cardiac rehabilitation: impact on illness knowledge and self-management behaviors up to 1 year. Health Educ Res. 2014;29(2):235–46.

    Article  PubMed  Google Scholar 

  65. Mertens A, Brandl C, Miron-Shatz T, Schlick C, Neumann T, Kribben A, et al. A mobile application improves therapy-adherence rates in elderly patients undergoing rehabilitation: a crossover design study comparing documentation via iPad with paper-based control. Medicine. 2016;95(36):e4446.

    Article  PubMed  PubMed Central  Google Scholar 

  66. Moise N, Khodneva Y, Richman J, Shimbo D, Kronish I, Safford MM. Elucidating the Association Between Depressive Symptoms, Coronary Heart Disease, and Stroke in Black and White Adults: The REasons for Geographic And Racial Differences in Stroke (REGARDS) Study. J Am Heart Assoc. 2016;5(8):e003767.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  67. Molloy GJ, Messerli-Burgy N, Hutton G, Wikman A, Perkins-Porras L, Steptoe A. Intentional and unintentional non-adherence to medications following an acute coronary syndrome: a longitudinal study. J Psychosom Res. 2014;76(5):430–2.

    Article  PubMed  PubMed Central  Google Scholar 

  68. Molloy GJ, Randall G, Wikman A, Perkins-Porras L, Messerli-Burgy N, Steptoe A. Type D personality, self-efficacy, and medication adherence following an acute coronary syndrome. Psychosom Med. 2012;74(1):100–6.

    Article  PubMed  Google Scholar 

  69. Mosleh SM, Almalik MM. Illness perception and adherence to healthy behaviour in Jordanian coronary heart disease patients. Eur J Cardiovasc Nurs: J Work Group Cardiovasc Nurs Eur Soc Cardiol. 2016;15(4):223–30.

    Article  Google Scholar 

  70. Mosleh SM, Darawad M. Patients' Adherence to healthy behavior in coronary heart disease: risk factor management among Jordanian patients. J Cardiovasc Nurs. 2015;30(6):471–8.

    Article  PubMed  Google Scholar 

  71. Muntner P, Yun H, Sharma P, Delzell E, Kent ST, Kilgore ML, et al. Ability of low antihypertensive medication adherence to predict statin discontinuation and low statin adherence in patients initiating treatment after a coronary event. Am J Cardiol. 2014;114(6):826–31.

    Article  PubMed  Google Scholar 

  72. Nord JW Jr, Berry A, Stults B, Burningham Z, Beddhu S. Evaluation of the effectiveness of a patient-centered educational mailer designed to improve statin adherence: a pragmatic trial. EGEMS (Washington, DC). 2016;4(1):1256.

    Google Scholar 

  73. Ose D, Rochon J, Campbell SM, Wensing M, van Lieshout J, Uhlmann L, et al. Secondary prevention in patients with coronary heart diseases: what factors are associated with health status in usual primary care? PLoS One. 2012;7(12):e51726.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  74. Park LG, Howie-Esquivel J, Chung ML, Dracup K. A text messaging intervention to promote medication adherence for patients with coronary heart disease: a randomized controlled trial. Patient Educ Couns. 2014;94(2):261–8.

    Article  PubMed  Google Scholar 

  75. Park LG, Howie-Esquivel J, Whooley MA, Dracup K. Psychosocial factors and medication adherence among patients with coronary heart disease: a text messaging intervention. Eur J Cardiovasc Nurs: J Work Group Cardiovasc Nurs Eur Soc Cardiol. 2015;14(3):264–73.

    Article  Google Scholar 

  76. Pedrosa RB, Rodrigues RC. Adaptation and evaluation of the measurement properties of the Brazilian version of the self-efficacy for appropriate medication adherence scale. Rev Lat Am Enfermagem. 2016;24:e2692.

    Article  PubMed  PubMed Central  Google Scholar 

  77. Pfaeffli Dale L, Whittaker R, Jiang Y, Stewart R, Rolleston A, Maddison R. Text message and internet support for coronary heart disease self-management: results from the Text4Heart randomized controlled trial. J Med Internet Res. 2015;17(10):e237.

    Article  PubMed  PubMed Central  Google Scholar 

  78. Pousinho S, Morgado M, Falcao A, Alves G. Pharmacist interventions in the Management of Type 2 diabetes mellitus: a systematic review of randomized controlled trials. J Manag Care Spec Pharm. 2016;22(5):493–515.

    Article  PubMed  Google Scholar 

  79. Sallis R, Franklin B, Joy L, Ross R, Sabgir D, Stone J. Strategies for promoting physical activity in clinical practice. Prog Cardiovasc Dis. 2015;57(4):375–86.

    Article  PubMed  Google Scholar 

  80. Santo K, Kirkendall S, Laba TL, Thakkar J, Webster R, Chalmers J, et al. Interventions to improve medication adherence in coronary disease patients: a systematic review and meta-analysis of randomised controlled trials. Eur J Prev Cardiol. 2016;23(10):1065–76.

    Article  PubMed  Google Scholar 

  81. Schneider KI, Schmidtke J. Patient compliance based on genetic medicine: a literature review. J Community Genet. 2014;5(1):31–48.

    Article  PubMed  Google Scholar 

  82. Simpson RJ Jr, Tunceli K, Ramey DR, Neff DR, Kern DM, Hsieh HM, et al. Treatment pattern changes in high-risk patients newly initiated on statin monotherapy in a managed care setting. J Clin Lipidol. 2013;7(5):399–407.

    Article  PubMed  Google Scholar 

  83. Sin NL, Kumar AD, Gehi AK, Whooley MA. Direction of association between depressive symptoms and lifestyle behaviors in patients with coronary heart disease: the heart and soul study. Ann Behav Med: Publ Soc Behav Med. 2016;50(4):523–32.

    Article  Google Scholar 

  84. Sin NL, Moskowitz JT, Whooley MA. Positive affect and health behaviors across 5 years in patients with coronary heart disease: the heart and soul study. Psychosom Med. 2015;77(9):1058–66.

    Article  PubMed  PubMed Central  Google Scholar 

  85. Son YJ, Shim SK, Hwang SY, Ahn JH, Yu HY. Impact of left ventricular ejection fraction and medication adherence on major adverse cardiac events during the first year after successful primary percutaneous coronary interventions. J Clin Nurs. 2016;25(7–8):1101–11.

    Article  PubMed  Google Scholar 

  86. Stamm-Balderjahn S, Brunger M, Michel A, Bongarth C, Spyra K. The efficacy of goal setting in cardiac rehabilitation-a gender-specific randomized controlled trial. Dtsch Arztebl Int. 2016;113(31–32):525–31.

    PubMed  PubMed Central  Google Scholar 

  87. Tsoi KK, Wong MC, Tam WW, Hirai HW, Lao XQ, Wang HH, et al. Cardiovascular mortality in hypertensive patients newly prescribed perindopril vs. lisinopril: a 5-year cohort study of 15,622 Chinese subjects. Int J Cardiol. 2014;176(3):703–9.

    Article  PubMed  Google Scholar 

  88. Varghese T, Schultz WM, McCue AA, Lambert CT, Sandesara PB, Eapen DJ, et al. Physical activity in the prevention of coronary heart disease: implications for the clinician. Heart. 2016;102(12):904–9.

    Article  PubMed  Google Scholar 

  89. Vorderstrasse AA, Ginsburg GS, Kraus WE, Maldonado MC, Wolever RQ. Health coaching and genomics-potential avenues to elicit behavior change in those at risk for chronic disease: protocol for personalized medicine effectiveness study in air force primary care. Glob Adv Health Med. 2013;2(3):26–38.

    Article  PubMed  PubMed Central  Google Scholar 

  90. Wald DS, Bestwick JP, Raiman L, Brendell R, Wald NJ. Randomised trial of text messaging on adherence to cardiovascular preventive treatment (INTERACT trial). PLoS One. 2014;9(12):e114268.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  91. Wong MC, Tam WW, Cheung CS, Wang HH, Tong EL, Sek AC, et al. Drug adherence and the incidence of coronary heart disease- and stroke-specific mortality among 218,047 patients newly prescribed an antihypertensive medication: a five-year cohort study. Int J Cardiol. 2013;168(2):928–33.

    Article  PubMed  Google Scholar 

  92. Yang EY, Chambless L, Sharrett AR, Virani SS, Liu X, Tang Z, et al. Carotid arterial wall characteristics are associated with incident ischemic stroke but not coronary heart disease in the atherosclerosis risk in communities (ARIC) study. Stroke. 2012;43(1):103–8.

    Article  CAS  PubMed  Google Scholar 

  93. Yudi MB, Clark DJ, Tsang D, Jelinek M, Kalten K, Joshi S, et al. SMARTphone-based, early cardiac REHABilitation in patients with acute coronary syndromes [SMART-REHAB trial]: a randomized controlled trial protocol. BMC Cardiovasc Disord. 2016;16(1):170.

    Article  PubMed  PubMed Central  Google Scholar 

  94. Zhao S, Zhao H, Wang L, Du S, Qin Y. Education is critical for medication adherence in patients with coronary heart disease. Acta Cardiol. 2015;70(2):197–204.

    Article  PubMed  Google Scholar 

  95. Zhao SJ, Zhao HW, Du S, Qin YH. The impact of clinical pharmacist support on patients receiving multi-drug therapy for coronary heart disease in China. Indian J Pharm Sci. 2015;77(3):306–11.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  96. Zhu L, Xu J, Wang Q, Xu F, Chen J. Nursing care of transradial angiography and intervention in a tertiary hospital in shanghai: a best practice implementation project. JBI Database Syst Rev Implement Rep. 2016;14(5):286–94.

    Article  Google Scholar 

  97. Morisky DE, Green LW, Levine DM. Concurrent and predictive validity of a self-reported measure of medication adherence. Med Care. 1986;24(1):67–74.

    Article  CAS  PubMed  Google Scholar 

  98. Morisky DE, Ang A, Krousel-Wood M, Ward HJ. Predictive validity of a medication adherence measure in an outpatient setting. J Clin Hypertens (Greenwich, Conn). 2008;10(5):348–54.

    Article  Google Scholar 

  99. Jank S, Bertsche T, Schellberg D, Herzog W, Haefeli WE. The A14-scale: development and evaluation of a questionnaire for assessment of adherence and individual barriers. Pharm World Sci: PWS. 2009;31(4):426–31.

    Article  PubMed  Google Scholar 

  100. Riddle MC, Rosenstock J, Gerich J. The treat-to-target trial: randomized addition of glargine or human NPH insulin to oral therapy of type 2 diabetic patients. Diabetes Care. 2003;26(11):3080–6.

    Article  CAS  PubMed  Google Scholar 

  101. Steiner JF, Prochazka AV. The assessment of refill compliance using pharmacy records: methods, validity, and applications. J Clin Epidemiol. 1997;50(1):105–16.

    Article  CAS  PubMed  Google Scholar 

  102. • Zullig LL, Mendys P, Bosworth HB. Medication adherence: a practical measurement selection guide using case studies. Patient Educ Couns. 2017;100(7):1410–4. This paper uses case studies to provide examples of selecting the appropraite medication adherence measures.

    Article  PubMed  Google Scholar 

  103. Lam WY, Fresco P. Medication adherence measures: an overview. Biomed Res Int. 2015;2015:217047.

    PubMed  PubMed Central  Google Scholar 

  104. Sheridan SL, Draeger LB, Pignone MP, Sloane PD, Samuel-Hodge C, Finkelstein EA, et al. Designing and implementing a comparative effectiveness study of two strategies for delivering high quality CHD prevention: methods and participant characteristics for the heart to health study. Contemp Clin Trials. 2013;36(2):394–405.

    Article  PubMed  PubMed Central  Google Scholar 

  105. Adler AJ, Martin N, Mariani J, Tajer CD, Owolabi OO, Free C, et al. Mobile phone text messaging to improve medication adherence in secondary prevention of cardiovascular disease. Cochrane Database Syst Rev. 2017;4:Cd011851.

    PubMed  Google Scholar 

  106. de Jongh T, Gurol-Urganci I, Vodopivec-Jamsek V, Car J, Atun R. Mobile phone messaging for facilitating self-management of long-term illnesses. Cochrane Database Syst Rev. 2012;12:Cd007459.

    PubMed  Google Scholar 

  107. DeKoekkoek T, Given B, Given CW, Ridenour K, Schueller M, Spoelstra SL. mHealth SMS text messaging interventions and to promote medication adherence: an integrative review. J Clin Nurs. 2015;24(19–20):2722–35.

    Article  PubMed  Google Scholar 

  108. Cutrona SL, Choudhry NK, Fischer MA, Servi A, Liberman JN, Brennan TA, et al. Modes of delivery for interventions to improve cardiovascular medication adherence. Am J Manag Care. 2010;16(12):929–42.

    PubMed  PubMed Central  Google Scholar 

  109. Teeter BS, Kavookjian J. Telephone-based motivational interviewing for medication adherence: a systematic review. Transl Behav Med. 2014;4(4):372–81.

    Article  PubMed  PubMed Central  Google Scholar 

  110. Kripalani S, Yao X, Haynes RB. Interventions to enhance medication adherence in chronic medical conditions: a systematic review. Arch Intern Med. 2007;167(6):540–50.

    Article  PubMed  Google Scholar 

  111. Kroenke K, Spitzer RL, Williams JB. The PHQ-9: validity of a brief depression severity measure. J Gen Intern Med. 2001;16(9):606–13.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  112. Glanz K, Rimer BK, Viswanath K. Health behavior and health education: theory, research, and practice. Hoboken: John Wiley & Sons; 2008.

    Google Scholar 

  113. Snyderman R. Personalized health care: from theory to practice. Biotechnol J. 2012;7(8):973–9.

    Article  CAS  PubMed  Google Scholar 

  114. Centers for Medicare and Medicaid Services. Choose higher quality for better health care. Available from: http://www.medicare.gov/Publications/Pubs/pdf/11226.pdf.

Download references

Acknowledgements

Dr. Zullig is supported by a VA Health Services Research and Development (HSR&D) Career Development Award (CDA 13-025). Dr. Bosworth is supported a VA Senior Career Scientist award from the VA HSR&D (VA HSR&D-8-297). This work was supported by the Center of Innovation for Health Services Research in Primary Care (CIN 13-410) at the Durham VA Health Care System.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Hayden B. Bosworth.

Ethics declarations

Conflict of Interest

Leah L. Zullig reports grants from PhRMA Foundation; a salary from the U.S. Department of Veterans Affairs, and from Duke University; and other from Novartis.

Hayden B. Bosworth reports grants and personal fees from Sanofi; personal fees from Genentech, Boehringer Ingelheim, and Ostuku; and grants from Improved Patient Outcomes and Johnson & Johnson.

Katherine Ramos declares that she has no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

Additional information

This article is part of the Topical Collection on Psychological Aspects of Cardiovascular Diseases

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Zullig, L.L., Ramos, K. & Bosworth, H.B. Improving Medication Adherence in Coronary Heart Disease. Curr Cardiol Rep 19, 113 (2017). https://doi.org/10.1007/s11886-017-0918-y

Download citation

  • Published:

  • DOI: https://doi.org/10.1007/s11886-017-0918-y

Keywords

Navigation