Skip to main content
Log in

Incomplete Closure of the Left Atrial Appendage: Implication and Management

  • Invasive Electrophysiology and Pacing (EK Heist, Section Editor)
  • Published:
Current Cardiology Reports Aims and scope Submit manuscript

Abstract

Incomplete left atrial appendage closure (LAAC) occurs in ∼30–40 % of cases following both surgical and percutaneous closure methods. Incomplete surgical LAAC may further be classified as incompletely surgically ligated LAA (ISLL) or LAA stump. ISLL is associated with a significantly increased risk of thrombus formation/thromboembolism. Moreover, this risk is highest in the absence of oral anticoagulation (OAC) and inversely correlates with the size of the ISLL neck. Not only routine screening for ISLL seems critical, but also long-term OAC should strongly be considered in this high-risk cohort. Alternatively, complete endocardial occlusion using a surrogate method may represent a reasonable option, particularly in those intolerant to long-term OAC therapy. Although thrombus formation/thromboembolic events have also been described in patients with incomplete LAAC following percutaneous occlusion, an association between the two remains less clear. However, given the rise and growing interest in percutaneous LAAC methods, additional research in this area is clearly warranted.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2

Similar content being viewed by others

References

Papers of particular interest, published recently, have been highlighted as: • Of importance

  1. Wolf PA, Abbott RD, Kannel WB. Atrial fibrillation as an independent risk factor for stroke: the Framingham study. Stroke. 1991;22:983–8.

    Article  CAS  PubMed  Google Scholar 

  2. Hart RG, Pearce LA, Aguilar MI. Meta-analysis: antithrombotic therapy to prevent stroke in patients who have nonvalvular atrial fibrillation. Ann Intern Med. 2007;146:857–67.

    Article  PubMed  Google Scholar 

  3. Glader EL, Sjolander M, Eriksson M, et al. Persistent use of secondary preventive drugs declines rapidly during the first 2 years after stroke. Stroke. 2010;41:397–401.

    Article  PubMed  Google Scholar 

  4. Connolly SJ, Ezekowitz MD, Yusuf S, RE-LY Steering Committee and Investigators, et al. Dabigatran versus warfarin in patients with atrial fibrillation. N Engl J Med. 2009;361:1139–51.

    Article  CAS  PubMed  Google Scholar 

  5. Patel MR, Mahaffey KW, Garg J, ROCKET AF Investigators, et al. Rivaroxaban versus warfarin in nonvalvular atrial fibrillation. N Engl J Med. 2011;365:883–91.

    Article  CAS  PubMed  Google Scholar 

  6. Granger CB, Alexander JH, McMurray JJ, ARISTOTLE Committees and Investigators, et al. Apixaban versus warfarin in patients with atrial fibrillation. N Engl J Med. 2011;365:981–92.

    Article  CAS  PubMed  Google Scholar 

  7. Blackshear JL, Odell JA. Appendage obliteration to reduce stroke in cardiac surgical patients with atrial fibrillation. Ann Thorac Surg. 1996;61:755–9.

    Article  CAS  PubMed  Google Scholar 

  8. Cruz-Gonzalez I, Yan BP, Lam YY. Left atrial appendage exclusion: state-of-the-art. Catheter Cardiovasc Interv. 2010;75:806–13.

    Article  PubMed  Google Scholar 

  9. Johnson WD, Ganjoo AK, Stone CD, et al. The left atrial appendage: our most lethal human attachment! Surgical implications. Eur J Cardiothorac Surg. 2000;17:718–22.

    Article  CAS  PubMed  Google Scholar 

  10. Mahajan R, Brooks AG, Sullivan T, et al. Importance of the underlying substrate in determining thrombus location in atrial fibrillation: implications for left atrial appendage closure. Heart. 2012;98:1120–6.

    Article  PubMed  Google Scholar 

  11. Di Biase L, Burkhardt JD, Mohanty P, Sanchez J, Mohanty S, Horton R, et al. Left atrial appendage: an underrecognized trigger site of atrial fibrillation. Circulation. 2010;122:109–18.

    Article  PubMed  Google Scholar 

  12. Cabrera JA, Ho SY, Climent V, Sánchez-Quintana D. The architecture of the left lateral atrial wall: a particular anatomic region with implications for ablation of atrial fibrillation. Eur Heart J. 2008;29:356–62.

    Article  PubMed  Google Scholar 

  13. Afzal MR, Kanmanthareddy A, Earnest M, Reddy M, Atkins D, Bommana S, et al. Impact of left atrial appendage exclusion using an epicardial ligation system (LARIAT) on atrial fibrillation burden in patients with cardiac implantable electronic devices. Heart Rhythm. 2015;12:52–9.

    Article  PubMed  Google Scholar 

  14. Bonow RO, Carabello BA, Chatterjee K, 2006 Writing Committee Members; American College of Cardiology/American Heart Association Task Force: 2008, et al. Focused update incorporated into the ACC/AHA 2006 guidelines for the management of patients with valvular heart disease: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 1998 Guidelines for the Management of Patients With Valvular Heart Disease): endorsed by the Society of Cardiovascular Anesthesiologists, Society for Cardiovascular Angiography and Interventions, and Society of Thoracic Surgeons. Circulation. 2008;118:e523–661.

    Article  PubMed  Google Scholar 

  15. Katz ES, Tsiamtsiouris T, Applebaum RM, et al. Surgical left atrial appendage ligation is frequently incomplete: a transesophageal echocardiographic study. J Am Coll Cardiol. 2000;36:468–71.

    Article  CAS  PubMed  Google Scholar 

  16. García-Fernández MA, Pérez-David E, Quiles J, et al. Role of left atrial appendage obliteration in stroke reduction in patients with mitral valve prosthesis: a transesophageal echocardiographic study. J Am Coll Cardiol. 2003;42:1253–8.

    Article  PubMed  Google Scholar 

  17. Cullen MW, Stulak JM, Li Z, et al. Left atrial appendage patency at cardioversion after surgical left atrial appendage intervention. Ann Thorac Surg. 2016;101:675–81.

    Article  PubMed  Google Scholar 

  18. Kanderian AS, Gillinov AM, Pettersson GB, et al. Success of surgical left atrial appendage closure—assessment by transoesophageal echocardiography. J Am Coll Cardiol. 2008;52:924–9.

    Article  PubMed  Google Scholar 

  19. Healey JS, Crystal E, Lamy A, et al. Left Atrial Appendage Occlusion Study (LAAOS): results of a randomized controlled pilot study of left atrial appendage occlusion during coronary bypass surgery in patients at risk for stroke. Am Heart J. 2005;150:288–93.

    Article  PubMed  Google Scholar 

  20. Bando K, Kobayashi J, Hirata M, et al. Early and late stroke after mitral valve replacement with a mechanical prosthesis: risk factor analysis of a 24-year experience. J Thorac Cardiovasc Surg. 2003;126:358–64.

    Article  PubMed  Google Scholar 

  21. Aryana A, Singh SK, Singh SM, et al. Association between incomplete surgical ligation of left atrial appendage and stroke and systemic embolization. Heart Rhythm. 2015;12:1431–7. The authors illustrate that in patients with atrial fibrillation, incompletely surgically-ligated left atrial appendage is a predictor of stroke/systemic embolization, independent of conventional risk stratification schemes. Consequently, oral anticoagulation should be strongly considered in this high-risk cohort.

    Article  PubMed  Google Scholar 

  22. Dawson AG, Asopa S, Dunning J. Should patients undergoing cardiac surgery with atrial fibrillation have left atrial appendage exclusion? Interact Cardiovasc Thorac Surg. 2010;10:306–11.

    Article  PubMed  Google Scholar 

  23. Di Biase L, Santangeli P, Anselmino M, et al. Does the left atrial appendage morphology correlate with the risk of stroke in patients with atrial fibrillation? Results from a multicenter study. J Am Coll Cardiol. 2012;60:531–8.

    Article  PubMed  Google Scholar 

  24. Syed FF, DeSimone CV, Friedman PA, et al. Left atrial appendage exclusion for atrial fibrillation. Cardiol Clin. 2014;32:601–25.

    Article  PubMed  PubMed Central  Google Scholar 

  25. Khurram IM, Dewire J, Mager M, et al. Relationship between left atrial appendage morphology and stroke in patients with atrial fibrillation. Heart Rhythm. 2013;10:1843–9. The authors show that in a large cohort of patients with drug-refractory atrial fibrillation undergoing catheter ablation therapy, the extent of left atrial appendage trabeculation and a smaller left atrial appendage orifice diameter were associated with increased prevalence of stroke or transient ischemic attack.

    Article  PubMed  Google Scholar 

  26. Schneider B, Stollberger C, Sievers HH. Surgical closure of the left atrial appendage—a beneficial procedure? Cardiology. 2005;104:127–32.

    Article  PubMed  Google Scholar 

  27. Aryana A, Saad EB, d’Avila A. Left atrial appendage occlusion and ligation devices: what is available, how to implement them, and how to manage and avoid complications. Curr Treat Options Cardiovasc Med. 2012;14:503–19.

    Article  PubMed  Google Scholar 

  28. Bordignon S, Fürnkranz A, Perrotta L, et al. Filling the gap: interventional occlusion of incompletely ligated left atrial appendages. Europace. 2015;17:64–8.

    Article  PubMed  Google Scholar 

  29. Aryana A, Cavaco D, Arthur A, et al. Percutaneous endocardial occlusion of incompletely surgically ligated left atrial appendage. J Cardiovasc Electrophysiol. 2013;24:968–74. The authors describe a novel approach for percutaneous endocardial occlusion of incompletely surgically-ligated left atrial appendage using an Amplatzer Septal Occluder device in a small cohort of patients with non-valvular atrial fibrillation.

    Article  PubMed  Google Scholar 

  30. Matsumoto T, Nakamura M, Yeow WL, et al. Transcatheter left atrial appendage closure after incomplete surgical ligation. JACC Cardiovasc Interv. 2013;6:e11–2.

    Article  PubMed  Google Scholar 

  31. Levisay JP, Sangodkar S, Salinger MH, et al. Percutaneous vascular plug for incomplete surgical left atrial appendage closure. J Invasive Cardiol. 2014;26:180–2.

    PubMed  Google Scholar 

  32. Kreidieh B, Rojas F, Schurmann P, et al. Left atrial appendage remodeling after lariat left atrial appendage ligation. Circ Arrhythm Electrophysiol. 2015;8:1351–8.

    PubMed  Google Scholar 

  33. Bai R, Horton RP, Di Biase L, et al. Intraprocedural and long-term incomplete occlusion of the left atrial appendage following placement of the WATCHMAN device: a single center experience. J Cardiovasc Electrophysiol. 2012;23:455–61.

    Article  PubMed  Google Scholar 

  34. Hanazawa K, Brunelli M, Geller JC. Thromboembolic stroke after cardioversion with incomplete left atrial appendage closure. Clin Res Cardiol. 2014;103:835–7.

    Article  PubMed  Google Scholar 

  35. Vorselaars VM, Velthuis S, Swaans MJ, et al. Percutaneous left atrial appendage closure—an alternative strategy for anticoagulation in atrial fibrillation and hereditary hemorrhagic telangiectasia? Cardiovasc Diagn Ther. 2015;5:49–53.

    PubMed  PubMed Central  Google Scholar 

  36. Lam SC, Bertog S, Sievert H. Incomplete left atrial appendage occlusion and thrombus formation after Watchman implantation treated with anticoagulation followed by further transcatheter closure with a second-generation Amplatzer Cardiac Plug (Amulet device). Catheter Cardiovasc Interv. 2015;85:321–7.

    Article  PubMed  Google Scholar 

  37. Price MJ, Gibson DN, Yakubov SJ, et al. Early safety and efficacy of percutaneous left atrial appendage suture ligation: results from the U.S. transcatheter LAA ligation consortium. J Am Coll Cardiol. 2014;64:565–72. In this multicenter experience of left atrial appendage ligation with the LARIAT device, as many as 20 % of the patients were found to exhibit a residual leak during follow-up and 5 % of the patients developed thrombi.

    Article  PubMed  PubMed Central  Google Scholar 

  38. Holmes DR, Reddy VY, Turi ZG, PROTECT AF Investigators, et al. Percutaneous closure of the left atrial appendage versus warfarin therapy for prevention of stroke in patients with atrial fibrillation: a randomised non-inferiority trial. Lancet. 2009;374:534–42.

    Article  CAS  PubMed  Google Scholar 

  39. Holmes Jr DR, Kar S, Price MJ, et al. Prospective randomized evaluation of the watchman left atrial appendage closure device in patients with atrial fibrillation versus long-term warfarin therapy: the PREVAIL trial. J Am Coll Cardiol. 2014;64:1–12.

    Article  PubMed  Google Scholar 

  40. Tzikas A, Shakir S, Gafoor S, et al. Left atrial appendage occlusion for stroke prevention in atrial fibrillation: multicentre experience with the AMPLATZER Cardiac Plug. Euro Intervention. 2016;11:1170–9.

    PubMed  Google Scholar 

  41. Bartus K, Han FT, Bednarek J, et al. Percutaneous left atrial appendage suture ligation using the LARIAT device in patients with atrial fibrillation: initial clinical experience. J Am Coll Cardiol. 2013;62:108–18.

    Article  PubMed  Google Scholar 

  42. Gafoor S, Franke J, Bertog S, et al. Left atrial appendage occlusion in octogenarians: short-term and 1-year follow-up. Catheter Cardiovasc Interv. 2014;83:805–10.

    Article  PubMed  Google Scholar 

  43. Baker MS, Paul Mounsey J, Gehi AK, et al. Left atrial thrombus after appendage ligation with LARIAT. Heart Rhythm. 2014;11:1489.

    Article  PubMed  Google Scholar 

  44. Briceno DF, Fernando RR, Laing ST. Left atrial appendage thrombus post LARIAT closure device. Heart Rhythm. 2014;11:1600–1.

    Article  PubMed  Google Scholar 

  45. Giedrimas E, Lin AC, Knight BP. Left atrial thrombus after appendage closure using LARIAT. Circ Arrhythm Electrophysiol. 2013;6:e52–3.

    Article  PubMed  Google Scholar 

  46. Truesdell AG, Patel CP, Maini BS. Late-occurring left atrial appendage thrombus after ligation using LARIAT. J Interv Card Electrophysiol. 2014;41:101.

    Article  PubMed  Google Scholar 

  47. Viles-Gonzalez JF, Reddy VY, Petru J, et al. Incomplete occlusion of the left atrial appendage with the percutaneous left atrial appendage transcatheter occlusion device is not associated with increased risk of stroke. J Interv Card Electrophysiol. 2012;33:69–75.

    Article  PubMed  Google Scholar 

  48. Viles-Gonzalez JF, Kar S, Douglas P, et al. The clinical impact of incomplete left atrial appendage closure with the Watchman Device in patients with atrial fibrillation: a PROTECT AF (Percutaneous Closure of the Left Atrial Appendage Versus Warfarin Therapy for Prevention of Stroke in Patients With Atrial Fibrillation) substudy. J Am Coll Cardiol. 2012;59:923–9.

    Article  PubMed  Google Scholar 

  49. Budera P, Straka Z, Osmančík P, et al. Comparison of cardiac surgery with left atrial surgical ablation vs. cardiac surgery without atrial ablation in patients with coronary and/or valvular heart disease plus atrial fibrillation: final results of the PRAGUE-12 randomized multicentre study. Eur Heart J. 2012;33:2644–52.

    Article  PubMed  PubMed Central  Google Scholar 

  50. Whitlock R, Healey J, Vincent J, et al. Rationale and design of the Left Atrial Appendage Occlusion Study (LAAOS) III. Ann Cardiothorac Surg. 2014;3:45–54.

    PubMed  PubMed Central  Google Scholar 

  51. Wunderlich N, Wilson N, Sievert H. A novel approach to treat residual peridevice leakage after left-atrial appendage closure. Catheter Cardiovasc Interv. 2013;82:313–9.

    Article  PubMed  Google Scholar 

  52. Pillai AM, Kanmanthareddy A, Earnest M, et al. Initial experience with post Lariat left atrial appendage leak closure with Amplatzer septal occluder device and repeat Lariat application. Heart Rhythm. 2014;11:1877–83. In this study, the authors show that left atrial appendage leaks from incomplete ligation the LARIAT procedure is not uncommon and can be successfully closed using an Amplatzer Septal Occluder device and in some cases using a repeat Lariat procedure.

    Article  PubMed  Google Scholar 

  53. Labovitz AJ, for the STEPS Investigators. Transesophageal echocardiography in patients with unexplained cerebral ischemia: multicenter findings. Circulation. 1994;90:1–21a.

  54. Vigna C, Russo A, De Rito V, et al. Frequency of left atrial thrombi by transesophageal echocardiography in idiopathic and in ischemic dilated cardiomyopathy. Am J Cardiol. 1992;70:1500–1.

    Article  CAS  PubMed  Google Scholar 

  55. Mügge A, Daniel WG, Hausmann D, et al. Diagnosis of left atrial appendage thrombi by transesophageal echocardiography: clinical implications and follow-up. Am J Cardiac Imag. 1990;4:173–9.

    Google Scholar 

  56. Aryana A, Bailey S, Gearoid O’Neill P, d’Avila A. Endocardial occlusion of incompletely surgically ligated left atrial appendage using an Amplatzer septal occluder device. Heart Rhythm. 2014;11:735–6.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Arash Aryana.

Ethics declarations

Conflict of Interest

Arash Aryana and André d’Avila declare that they have no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

Additional information

This article is part of the Topical Collection on Invasive Electrophysiology and Pacing

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Aryana, A., d’Avila, A. Incomplete Closure of the Left Atrial Appendage: Implication and Management. Curr Cardiol Rep 18, 82 (2016). https://doi.org/10.1007/s11886-016-0765-2

Download citation

  • Published:

  • DOI: https://doi.org/10.1007/s11886-016-0765-2

Keywords

Navigation