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Cannabis, Cannabinoids, and Cerebral Metabolism: Potential Applications in Stroke and Disorders of the Central Nervous System

Abstract

No compound has generated more attention in both the scientific and recently in the political arena as much as cannabinoids. These diverse groups of compounds referred collectively as cannabinoids have both been vilified due to its dramatic and potentially harmful psychotropic effects and glorified due to its equally dramatic and potential application in a number of acute and chronic neurological conditions. Previously illegal to possess, cannabis, the plant where natural form of cannabinoids are derived, is now accepted in a growing number of states for medicinal purpose, and some even for recreational use, increasing opportunities for more scientific experimentation. The purpose of this review is to summarize the growing body of literature on cannabinoids and to present an overview of our current state of knowledge of the human endocannabinoid system in the hope of defining the future of cannabinoids and its potential applications in disorders of the central nervous system, focusing on stroke.

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Julius Gene S. Latorre and Elena B. Schmidt declare that they have no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

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Correspondence to Julius Gene S. Latorre.

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This article is part of the Topical Collection on Stroke

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Latorre, J.G.S., Schmidt, E.B. Cannabis, Cannabinoids, and Cerebral Metabolism: Potential Applications in Stroke and Disorders of the Central Nervous System. Curr Cardiol Rep 17, 72 (2015). https://doi.org/10.1007/s11886-015-0627-3

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  • DOI: https://doi.org/10.1007/s11886-015-0627-3

Keywords

  • Cannabinoid
  • Stroke
  • Cannabis
  • Neuroprotection
  • Ischemia
  • Endocannabinoids