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Current State of Anticoagulants to Treat Deep Venous Thrombosis

  • Peripheral Vascular Disease (MH Shishehbor, Section Editor)
  • Published:
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Abstract

Anticoagulation remains the cornerstone of treatment in patients with deep vein thrombosis (DVT). While parenteral anticoagulants and oral vitamin K antagonists (e.g., warfarin) have been used for many decades, the recent development of novel oral anticoagulants have provided clinicians with an expanding set of therapeutic options for DVT. This review summarizes the pharmacology and clinical trial results of these new oral anticoagulants. Several practical considerations to the use of these oral anticoagulants including issues related to adherence, monitoring, and reversal are also discussed.

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Acknowledgments

This work was supported by the National Institutes of Health and the National Institute of Aging (K23HL092161 and R03AG040631 to M.T.R.). We thank Ms. Alex Greer for her excellent editorial assistance.

Compliance with Ethics Guidelines

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Conflict of Interest

Timothy Vo declares that he has no conflict of interest.

Sara Vazquez declares that she has no conflict of interest.

Matthew T. Rondina has received honoraria from Boehringer Ingelheim for Advisory Board participation.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

Author information

Authors and Affiliations

  1. SUNY Upstate Medical University, Syracuse, NY, 13210, USA

    Timothy Vo

  2. Department of Pharmacy Services, University of Utah Health Care Thrombosis Center, Salt Lake City, UT, 84132, USA

    Sara Vazquez

  3. Division of General Internal Medicine and University Healthcare Thrombosis Service, Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, UT, 84132, USA

    Matthew T. Rondina

  4. Program in Molecular Medicine, University of Utah Health Sciences Center, Salt Lake City, UT, 84132, USA

    Matthew T. Rondina

  5. Department of Internal Medicine, Eccles Institute of Human Genetics, University of Utah, 15 North 2030 East, Bldg 533, Suite 4220, Salt Lake City, UT, 84112, USA

    Matthew T. Rondina

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  1. Timothy Vo
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Correspondence to Matthew T. Rondina.

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This article is part of the Topical Collection on Peripheral Vascular Disease

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Vo, T., Vazquez, S. & Rondina, M.T. Current State of Anticoagulants to Treat Deep Venous Thrombosis. Curr Cardiol Rep 16, 463 (2014). https://doi.org/10.1007/s11886-013-0463-2

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  • DOI: https://doi.org/10.1007/s11886-013-0463-2

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