Current Cardiology Reports

, 15:403 | Cite as

Coffee Consumption and Cardiovascular Health: Getting to the Heart of the Matter

  • Salome A. RebelloEmail author
  • Rob M. van Dam
Ischemic Heart Disease (D Mukherjee, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Ischemic Heart Disease


As coffee-consumption is a widespread tradition, its possible impact on health has been of considerable interest. This review examines the effects of coffee on cardiovascular risk, outlines underlying biological mechanisms, and discusses implications for public health. In the past, coffee was often viewed as a cardiovascular risk-factor. However, in meta-analyses of recent well-controlled prospective epidemiologic studies, coffee-consumption was not associated with risk of coronary heart disease and weakly associated with a lower risk of stroke and heart failure. Also, available evidence largely suggests that coffee-consumption is not associated with a higher risk of fatal cardiovascular events. In randomized trials coffee-consumption resulted in small increases in blood pressure. Unfiltered coffee increased circulating LDL cholesterol and triglycerides concentrations, but filtered coffee had no substantial effects on blood lipids. In summary, for most healthy people, moderate coffee consumption is unlikely to adversely affect cardiovascular health. Future work should prioritize understanding the effects of coffee in at-risk populations.


Coffee Coronary heart disease Stroke Type-2 diabetes Blood lipids Blood pressure Inflammation Insulin resistance Heart failure Arrhythmias Homocysteine Cardiovascular mortality 


Compliance with Ethics Guidelines

Conflict of Interest

Salome A. Rebello is a co-investigator on Nestle Research Center funded clinical trial. Rob M. van Dam is a Principal Investigator on a Nestle Research Center funded clinical trial. He has received research funds from Nestle Research Center; has received travel/accommodation expenses covered for unpaid scientific talk.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.


Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

  1. 1.
    • Beaudoin MS, Graham TE. Methylxanthines and human health: epidemiological and experimental evidence. Handb Exp Pharmacol. 2011:509–48. This article summarizes the evidence on the effects of caffeine on glucose homeostasis and provides details on potential mechanisms of actions. Google Scholar
  2. 2.
    Noordzij M, Uiterwaal CS, Arends LR, et al. Blood pressure response to chronic intake of coffee and caffeine: a meta-analysis of randomized controlled trials. J Hypertens. 2005;23:921–8.PubMedCrossRefGoogle Scholar
  3. 3.
    • Pelchovitz DJ, Goldberger JJ. Caffeine and cardiac arrhythmias: a review of the evidence. Am J Med. 2011;124:284–9. This article summarizes the evidence on the effects of caffeine and coffee on arrthymia.PubMedCrossRefGoogle Scholar
  4. 4.
    Kawachi I, Colditz GA, Stone CB. Does coffee drinking increase the risk of coronary heart disease? Results from a meta-analysis. Br Heart J. 1994;72:269–75.PubMedCrossRefGoogle Scholar
  5. 5.
    Sofi F, Conti AA, Gori AM, et al. Coffee consumption and risk of coronary heart disease: a meta-analysis. Nutr Metab Cardiovasc Dis. 2007;17:209–23.PubMedCrossRefGoogle Scholar
  6. 6.
    •• Wu JN, Ho SC, Zhou C, et al. Coffee consumption and risk of coronary heart diseases: a meta-analysis of 21 prospective cohort studies. Int J Cardiol. 2009;137:216–25. This meta-analysis of prospective studies observed that coffee consumption was not associated with risk of coronary heart disease.PubMedCrossRefGoogle Scholar
  7. 7.
    van Dam RM. Coffee consumption and coronary heart disease: paradoxical effects on biological risk factors vs disease incidence. Clin Chem. 2008;54:1418–20.PubMedCrossRefGoogle Scholar
  8. 8.
    Tunnicliffe JM, Shearer J. Coffee, glucose homeostasis, and insulin resistance: physiological mechanisms and mediators. Appl Physiol Nutr Metab. 2008;33:1290–300.PubMedCrossRefGoogle Scholar
  9. 9.
    Kempf K, Herder C, Erlund I, et al. Effects of coffee consumption on subclinical inflammation and other risk factors for type 2 diabetes: a clinical trial. Am J Clin Nutr. 2010;91:950–7.PubMedCrossRefGoogle Scholar
  10. 10.
    Wedick NM, Brennan AM, Sun Q, et al. Effects of caffeinated and decaffeinated coffee on biological risk factors for type 2 diabetes: a randomized controlled trial. Nutr J. 2011;10:93.PubMedCrossRefGoogle Scholar
  11. 11.
    Williams CJ, Fargnoli JL, Hwang JJ, et al. Coffee consumption is associated with higher plasma adiponectin concentrations in women with or without type 2 diabetes: a prospective cohort study. Diabetes Care. 2008;31:504–7.PubMedCrossRefGoogle Scholar
  12. 12.
    •• Huxley R, Lee CM, Barzi F, et al. Coffee, decaffeinated coffee, and tea consumption in relation to incident type 2 diabetes mellitus: a systematic review with meta-analysis. Arch Intern Med. 2009;169:2053–63. This meta-analysis of prospective studies observed that coffee consumption was associated with a lower risk of type-2 diabetes.PubMedCrossRefGoogle Scholar
  13. 13.
    •• Zhang Z, Hu G, Caballero B, et al. Habitual coffee consumption and risk of hypertension: a systematic review and meta-analysis of prospective observational studies. Am J Clin Nutr. 2011;93:1212–9. This meta-analysis of prospective studies observed that habitual coffee consumption was modestly associated with a higher risk of hypertension.PubMedCrossRefGoogle Scholar
  14. 14.
    •• Mostofsky E, Rice MS, Levitan EB, Mittleman MA. Habitual coffee consumption and risk of heart failure: a dose–response meta-analysis. Circ Heart Fail. 2012;5:401–5. This meta-analyses of prospective studies observed that habitual coffee consumption was weakly associated with a lower risk of heart-failure.PubMedCrossRefGoogle Scholar
  15. 15.
    •• Mesas AE, Leon-Munoz LM, Rodriguez-Artalejo F, Lopez-Garcia E. The effect of coffee on blood pressure and cardiovascular disease in hypertensive individuals: a systematic review and meta-analysis. Am J Clin Nutr. 2011;94:1113–26. This paper shows that caffiene intake increases blood pressure in hypertensive individuals for at least 3 hours after intake.PubMedCrossRefGoogle Scholar
  16. 16.
    •• Larsson SC, Orsini N. Coffee consumption and risk of stroke: a dose–response meta-analysis of prospective studies. Am J Epidemiol. 2011;174:993–1001. This meta-analysis of prospective studies observed that habitual coffee consumption was weakly associated with a lower risk of stroke.PubMedCrossRefGoogle Scholar
  17. 17.
    •• Cai L, Ma D, Zhang Y, et al. The effect of coffee consumption on serum lipids: a meta-analysis of randomized controlled trials. Eur J Clin Nutr. 2012;66:872–7. This meta-analysis of randomized-trials shows that unfiltered types of coffee increases circulating levels of LDL cholesterol and triglycerides. Much smaller and nonsignificant increases in plasma LDL cholesterol and triglycerides concentrations were noted with filtered coffee intake.PubMedCrossRefGoogle Scholar
  18. 18.
    •• Steffen M, Kuhle C, Hensrud D, et al. The effect of coffee consumption on blood pressure and the development of hypertension: a systematic review and meta-analysis. J Hypertens. 2012;30:2245–54. This meta-analysis of randomized trials showed that coffee consumption did not increase blood pressure as compared with not consuming coffee or consuming lower amounts of coffee. Significant heterogenity for changes in systolic blood pressure was observed which was not explained by differences due to type of coffee (caffeinated or decaffeinated), prepartion method (boiled, instant or filtered), hypertension status or sex.PubMedCrossRefGoogle Scholar
  19. 19.
    Moreira AS, Nunes FM, Domingues MR, Coimbra MA. Coffee melanoidins: structures, mechanisms of formation and potential health impacts. Food Funct. 2012;3:903–15.PubMedCrossRefGoogle Scholar
  20. 20.
    Farah A. Coffee constituents. In: Chu YF, editor. Coffee: emerging health effects and disease prevention. Iowa: Wiley-Blackwell/IFT Press; 2012. p. 22–57.Google Scholar
  21. 21.
    Casal S, Oliveira MB, Alves MR, Ferreira MA. Discriminate analysis of roasted coffee varieties for trigonelline, nicotinic acid, and caffeine content. J Agric Food Chem. 2000;48:3420–4.PubMedCrossRefGoogle Scholar
  22. 22.
    Urgert R, Essed N, van der Weg G, et al. Separate effects of the coffee diterpenes cafestol and kahweol on serum lipids and liver aminotransferases. Am J Clin Nutr. 1997;65:519–24.PubMedGoogle Scholar
  23. 23.
    Urgert R, Katan MB. The cholesterol-raising factor from coffee beans. Annu Rev Nutr. 1997;17:305–24.PubMedCrossRefGoogle Scholar
  24. 24.
    Heckman MA, Weil J, Gonzalez de Mejia E. Caffeine (1, 3, 7-trimethylxanthine) in foods: a comprehensive review on consumption, functionality, safety, and regulatory matters. J Food Sci. 2010;75:R77–87.PubMedCrossRefGoogle Scholar
  25. 25.
    Nurminen ML, Niittynen L, Korpela R, Vapaatalo H. Coffee, caffeine and blood pressure: a critical review. Eur J Clin Nutr. 1999;53:831–9.PubMedCrossRefGoogle Scholar
  26. 26.
    Varani K, Portaluppi F, Gessi S, et al. Dose and time effects of caffeine intake on human platelet adenosine A(2A) receptors: functional and biochemical aspects. Circulation. 2000;102:285–9.PubMedCrossRefGoogle Scholar
  27. 27.
    Rakic V, Burke V, Beilin LJ. Effects of coffee on ambulatory blood pressure in older men and women: a randomized controlled trial. Hypertension. 1999;33:869–73.PubMedCrossRefGoogle Scholar
  28. 28.
    Geleijnse JM. Habitual coffee consumption and blood pressure: an epidemiological perspective. Vasc Health Risk Manag. 2008;4:963–70.PubMedGoogle Scholar
  29. 29.
    de Paulis T, Schmidt DE, Bruchey AK, et al. Dicinnamoylquinides in roasted coffee inhibit the human adenosine transporter. Eur J Pharmacol. 2002;442:215–23.PubMedCrossRefGoogle Scholar
  30. 30.
    Watanabe T, Arai Y, Mitsui Y, et al. The blood pressure-lowering effect and safety of chlorogenic acid from green coffee bean extract in essential hypertension. Clin Exp Hypertens. 2006;28:439–49.PubMedCrossRefGoogle Scholar
  31. 31.
    Mubarak A, Bondonno CP, Liu AH, et al. Acute effects of chlorogenic acid on nitric oxide status, endothelial function, and blood pressure in healthy volunteers: a randomized trial. J Agric Food Chem. 2012;60:9130–6.PubMedCrossRefGoogle Scholar
  32. 32.
    Zhao Y, Wang J, Ballevre O, et al. Antihypertensive effects and mechanisms of chlorogenic acids. Hypertens Res. 2012;35:370–4.PubMedCrossRefGoogle Scholar
  33. 33.
    Chikama A, Yamaguchi T, Ochiai R, et al. Effects of hydroxyhydroquinone-reduced coffee on blood pressure in high-normotensives and mild hypertensives. J Health Sci. 2008;54:162–73.CrossRefGoogle Scholar
  34. 34.
    Yamaguchi T, Chikama A, Mori K, et al. Hydroxyhydroquinone-free coffee: a double-blind, randomized controlled dose–response study of blood pressure. Nutr Metab Cardiovasc Dis. 2008;18:408–14.PubMedCrossRefGoogle Scholar
  35. 35.
    Natella F, Scaccini C. Role of coffee in modulation of diabetes risk. Nutr Rev. 2012;70:207–17.PubMedCrossRefGoogle Scholar
  36. 36.
    Correa TA, Monteiro MP, Mendes TM, et al. Medium light and medium roast paper-filtered coffee increased antioxidant capacity in healthy volunteers: results of a randomized trial. Plant Foods Hum Nutr. 2012;67:277–82.PubMedCrossRefGoogle Scholar
  37. 37.
    Bichler J, Cavin C, Simic T, et al. Coffee consumption protects human lymphocytes against oxidative and 3-amino-1-methyl-5H-pyrido[4,3-b]indole acetate (Trp-P-2) induced DNA-damage: results of an experimental study with human volunteers. Food Chem Toxicol. 2007;45:1428–36.PubMedCrossRefGoogle Scholar
  38. 38.
    Bakuradze T, Boehm N, Janzowski C, et al. Antioxidant-rich coffee reduces DNA damage, elevates glutathione status and contributes to weight control: results from an intervention study. Mol Nutr Food Res. 2011;55:793–7.PubMedCrossRefGoogle Scholar
  39. 39.
    Hoelzl C, Knasmuller S, Wagner KH, et al. Instant coffee with high chlorogenic acid levels protects humans against oxidative damage of macromolecules. Mol Nutr Food Res. 2010;54:1722–33.PubMedCrossRefGoogle Scholar
  40. 40.
    Natella F, Nardini M, Belelli F, Scaccini C. Coffee drinking induces incorporation of phenolic acids into LDL and increases the resistance of LDL to ex vivo oxidation in humans. Am J Clin Nutr. 2007;86:604–9.PubMedGoogle Scholar
  41. 41.
    Maki T, Pham NM, Yoshida D, et al. The relationship of coffee and green tea consumption with high-sensitivity C-reactive protein in Japanese men and women. Clin Chem Lab Med. 2010;48:849–54.PubMedCrossRefGoogle Scholar
  42. 42.
    Rebello SA, Chen CH, Naidoo N, et al. Coffee and tea consumption in relation to inflammation and basal glucose metabolism in a multi-ethnic Asian population: a cross-sectional study. Nutr J. 2011;10:61.PubMedCrossRefGoogle Scholar
  43. 43.
    Zampelas A, Panagiotakos DB, Pitsavos C, et al. Associations between coffee consumption and inflammatory markers in healthy persons: the ATTICA study. Am J Clin Nutr. 2004;80:862–7.PubMedGoogle Scholar
  44. 44.
    Lopez-Garcia E, van Dam RM, Qi L, Hu FB. Coffee consumption and markers of inflammation and endothelial dysfunction in healthy and diabetic women. Am J Clin Nutr. 2006;84:888–93.PubMedGoogle Scholar
  45. 45.
    Yamashita K, Yatsuya H, Muramatsu T, et al. Association of coffee consumption with serum adiponectin, leptin, inflammation and metabolic markers in Japanese workers: a cross-sectional study. Nutr Diabetes. 2012;2:e33.PubMedCrossRefGoogle Scholar
  46. 46.
    Imatoh T, Tanihara S, Miyazaki M, et al. Coffee consumption but not green tea consumption is associated with adiponectin levels in Japanese males. Eur J Nutr. 2011;50:279–84.PubMedCrossRefGoogle Scholar
  47. 47.
    Saito M, Nemoto T, Tobimatsu S, et al. Coffee consumption and cystatin-C-based estimated glomerular filtration rates in healthy young adults: results of a clinical trial. J Nutr Metab. 2011;2011:146865.PubMedGoogle Scholar
  48. 48.
    van Woudenbergh GJ, Vliegenthart R, van Rooij FJ, et al. Coffee consumption and coronary calcification: the Rotterdam Coronary Calcification Study. Arterioscler Thromb Vasc Biol. 2008;28:1018–23.PubMedCrossRefGoogle Scholar
  49. 49.
    Reis JP, Loria CM, Steffen LM, et al. Coffee, decaffeinated coffee, caffeine, and tea consumption in young adulthood and atherosclerosis later in life: the CARDIA study. Arterioscler Thromb Vasc Biol. 2010;30:2059–66.PubMedCrossRefGoogle Scholar
  50. 50.
    van Dam RM. Coffee consumption and risk of type 2 diabetes, cardiovascular diseases, and cancer. Appl Physiol Nutr Metab. 2008;33:1269–83.PubMedCrossRefGoogle Scholar
  51. 51.
    Goto A, Song Y, Chen BH, et al. Coffee and caffeine consumption in relation to sex hormone-binding globulin and risk of type 2 diabetes in postmenopausal women. Diabetes. 2011;60:269–75.PubMedCrossRefGoogle Scholar
  52. 52.
    Zhang Y, Lee ET, Cowan LD, et al. Coffee consumption and the incidence of type 2 diabetes in men and women with normal glucose tolerance: the Strong Heart Study. Nutr Metab Cardiovasc Dis. 2011;21:418–23.PubMedCrossRefGoogle Scholar
  53. 53.
    Bhupathiraju SN, Pan A, Malik VS, et al. Caffeinated and caffeine-free beverages and risk of type 2 diabetes. Am J Clin Nutr. 2013;97:155–66.PubMedCrossRefGoogle Scholar
  54. 54.
    van Dam RM. Coffee and type 2 diabetes: from beans to beta-cells. Nutr Metab Cardiovasc Dis. 2006;16:69–77.PubMedCrossRefGoogle Scholar
  55. 55.
    Ohnaka K, Ikeda M, Maki T, et al. Effects of 16-week consumption of caffeinated and decaffeinated instant coffee on glucose metabolism in a randomized controlled trial. J Nutr Metab. 2012;2012:207426.PubMedGoogle Scholar
  56. 56.
    Whitehead N, White H. Systematic review of randomised controlled trials of the effects of caffeine or caffeinated drinks on blood glucose concentrations and insulin sensitivity in people with diabetes mellitus. J Hum Nutr Dietet. 2013;26(2):111–25.Google Scholar
  57. 57.
    Urgert R, van Vliet T, Zock PL, Katan MB. Heavy coffee consumption and plasma homocysteine: a randomized controlled trial in healthy volunteers. Am J Clin Nutr. 2000;72:1107–10.PubMedGoogle Scholar
  58. 58.
    Grubben MJ, Boers GH, Blom HJ, et al. Unfiltered coffee increases plasma homocysteine concentrations in healthy volunteers: a randomized trial. Am J Clin Nutr. 2000;71:480–4.PubMedGoogle Scholar
  59. 59.
    Verhoef P, Pasman WJ, Van Vliet T, et al. Contribution of caffeine to the homocysteine-raising effect of coffee: a randomized controlled trial in humans. Am J Clin Nutr. 2002;76:1244–8.PubMedGoogle Scholar
  60. 60.
    Olthof MR, Hollman PC, Zock PL, Katan MB. Consumption of high doses of chlorogenic acid, present in coffee, or of black tea increases plasma total homocysteine concentrations in humans. Am J Clin Nutr. 2001;73:532–8.PubMedGoogle Scholar
  61. 61.
    Panagiotakos DB, Pitsavos C, Zampelas A, et al. The association between coffee consumption and plasma total homocysteine levels: the "ATTICA" study. Heart Vessels. 2004;19:280–6.PubMedCrossRefGoogle Scholar
  62. 62.
    Marti-Carvajal AJ, Sola I, Lathyris D, Salanti G. Homocysteine lowering interventions for preventing cardiovascular events. Cochrane Database Syst Rev. 2009;CD006612.Google Scholar
  63. 63.
    Qin X, Huo Y, Xie D, et al. Homocysteine-lowering therapy with folic acid is effective in cardiovascular disease prevention in patients with kidney disease: a meta-analysis of randomized controlled trials. Clin Nutr. 2012;S0261–5614(12):00280–4.Google Scholar
  64. 64.
    Lopez-Garcia E, Rodriguez-Artalejo F, Li TY, et al. Coffee consumption and mortality in women with cardiovascular disease. Am J Clin Nutr. 2011;94:218–24.PubMedCrossRefGoogle Scholar
  65. 65.
    Mineharu Y, Koizumi A, Wada Y, et al. Coffee, green tea, black tea and oolong tea consumption and risk of mortality from cardiovascular disease in Japanese men and women. J Epidemiol Community Health. 2011;65:230–40.PubMedCrossRefGoogle Scholar
  66. 66.
    Klatsky AL, Koplik S, Kipp H, Friedman GD. The confounded relation of coffee drinking to coronary artery disease. Am J Cardiol. 2008;101:825–7.PubMedCrossRefGoogle Scholar
  67. 67.
    Gurpegui M, Jurado D, Luna JD, et al. Personality traits associated with caffeine intake and smoking. Prog Neuropsychopharmacol Biol Psychiatry. 2007;31:997–1005.PubMedCrossRefGoogle Scholar
  68. 68.
    Mukamal KJ, Hallqvist J, Hammar N, et al. Coffee consumption and mortality after acute myocardial infarction: the Stockholm Heart Epidemiology Program. Am Heart J. 2009;157:495–501.PubMedCrossRefGoogle Scholar
  69. 69.
    Cornelis MC. Coffee intake. Prog Mol Biol Transl Sci. 2012;108:293–322.PubMedCrossRefGoogle Scholar
  70. 70.
    Cornelis MC, El-Sohemy A, Kabagambe EK, Campos H. Coffee, CYP1A2 genotype, and risk of myocardial infarction. JAMA. 2006;295:1135–41.PubMedCrossRefGoogle Scholar
  71. 71.
    Palatini P, Ceolotto G, Ragazzo F, et al. CYP1A2 genotype modifies the association between coffee intake and the risk of hypertension. J Hypertens. 2009;27:1594–601.Google Scholar
  72. 72.
    Floegel A, Pischon T, Bergmann MM, et al. Coffee consumption and risk of chronic disease in the European Prospective Investigation into Cancer and Nutrition (EPIC)-Germany study. Am J Clin Nutr. 2012;95:901–8.PubMedCrossRefGoogle Scholar
  73. 73.
    LaCroix AZ, Mead LA, Liang KY, et al. Coffee consumption and the incidence of coronary heart disease. N Engl J Med. 1986;315:977–82.PubMedCrossRefGoogle Scholar
  74. 74.
    Lopez-Garcia E, van Dam RM, Willett WC, et al. Coffee consumption and coronary heart disease in men and women: a prospective cohort study. Circulation. 2006;113:2045–53.PubMedCrossRefGoogle Scholar
  75. 75.
    de Koning Gans JM, Uiterwaal CS, van der Schouw YT, et al. Tea and coffee consumption and cardiovascular morbidity and mortality. Arterioscler Thromb Vasc Biol. 2010;30:1665–71.PubMedCrossRefGoogle Scholar
  76. 76.
    Sugiyama K, Kuriyama S, Akhter M, et al. Coffee consumption and mortality due to all causes, cardiovascular disease, and cancer in Japanese women. J Nutr. 2010;140:1007–13.PubMedCrossRefGoogle Scholar
  77. 77.
    Freedman ND, Park Y, Abnet CC, et al. Association of coffee drinking with total and cause-specific mortality. N Engl J Med. 2012;366:1891–904.PubMedCrossRefGoogle Scholar
  78. 78.
    Lopez-Garcia E, van Dam RM, Li TY, et al. The relationship of coffee consumption with mortality. Ann Intern Med. 2008;148:904–14.PubMedCrossRefGoogle Scholar
  79. 79.
    Leurs LJ, Schouten LJ, Goldbohm RA, van den Brandt PA. Total fluid and specific beverage intake and mortality due to IHD and stroke in The Netherlands Cohort Study. Br J Nutr. 2010;104:1212–21.PubMedCrossRefGoogle Scholar
  80. 80.
    Kokubo Y, Iso H, Saito I, et al. The impact of green tea and coffee consumption on the reduced risk of stroke incidence in Japanese population: The Japan Public Health Center-Based Study Cohort. Stroke. 2013;44(5):1369–74.Google Scholar
  81. 81.
    Lopez-Garcia E, Rodriguez-Artalejo F, Rexrode KM, et al. Coffee consumption and risk of stroke in women. Circulation. 2009;119:1116–23.PubMedCrossRefGoogle Scholar
  82. 82.
    Riksen NP, Rongen GA, Smits P. Acute and long-term cardiovascular effects of coffee: implications for coronary heart disease. Pharmacol Ther. 2009;121:185–91.PubMedCrossRefGoogle Scholar
  83. 83.
    de Vreede-Swagemakers JJ, Gorgels AP, Weijenberg MP, et al. Risk indicators for out-of-hospital cardiac arrest in patients with coronary artery disease. J Clin Epidemiol. 1999;52:601–7.PubMedCrossRefGoogle Scholar
  84. 84.
    Mukamal KJ, Maclure M, Muller JE, et al. Caffeinated coffee consumption and mortality after acute myocardial infarction. Am Heart J. 2004;147:999–1004.PubMedCrossRefGoogle Scholar
  85. 85.
    Silletta MG, Marfisi R, Levantesi G, et al. Coffee consumption and risk of cardiovascular events after acute myocardial infarction: results from the GISSI (Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto miocardico)-Prevenzione trial. Circulation. 2007;116:2944–51.PubMedCrossRefGoogle Scholar
  86. 86.
    Zhang W, Lopez-Garcia E, Li TY, et al. Coffee consumption and risk of cardiovascular diseases and all-cause mortality among men with type 2 diabetes. Diabetes Care. 2009;32:1043–5.PubMedCrossRefGoogle Scholar
  87. 87.
    Zhang WL, Lopez-Garcia E, Li TY, et al. Coffee consumption and risk of cardiovascular events and all-cause mortality among women with type 2 diabetes. Diabetologia. 2009;52:810–7.PubMedCrossRefGoogle Scholar
  88. 88.
    Bidel S, Hu G, Qiao Q, et al. Coffee consumption and risk of total and cardiovascular mortality among patients with type 2 diabetes. Diabetologia. 2006;49:2618–26.PubMedCrossRefGoogle Scholar
  89. 89.
    Baylin A, Hernandez-Diaz S, Kabagambe EK, et al. Transient exposure to coffee as a trigger of a first nonfatal myocardial infarction. Epidemiology. 2006;17:506–11.PubMedCrossRefGoogle Scholar
  90. 90.
    Mostofsky E, Schlaug G, Mukamal KJ, et al. Coffee and acute ischemic stroke onset: the Stroke Onset Study. Neurology. 2010;75:1583–8.PubMedCrossRefGoogle Scholar
  91. 91.
    Selb Semerl J, Selb K. Coffee and alcohol consumption as triggering factors for sudden cardiac death: case-crossover study. Croat Med J. 2004;45:775–80.PubMedGoogle Scholar
  92. 92.
    Mittleman MA, Mostofsky E. Physical, psychological and chemical triggers of acute cardiovascular events: preventive strategies. Circulation. 2011;124:346–54.PubMedCrossRefGoogle Scholar
  93. 93.
    Perera V, Gross AS, McLachlan AJ. Influence of environmental and genetic factors on CYP1A2 activity in individuals of South Asian and European ancestry. Clin Pharmacol Ther. 2012;92:511–9.PubMedGoogle Scholar
  94. 94.
    Bernstein AM, de Koning L, Flint AJ, et al. Soda consumption and the risk of stroke in men and women. Am J Clin Nutr. 2012;95:1190–9.PubMedCrossRefGoogle Scholar
  95. 95.
    Pan A, Malik VS, Hao T, et al. Changes in water and beverage intake and long-term weight changes: results from three prospective cohort studies. Int J Obes (Lond). 2013.Google Scholar
  96. 96.
    Mensink RP, Lebbink WJ, Lobbezoo IE, et al. Diterpene composition of oils from Arabica and Robusta coffee beans and their effects on serum lipids in man. J Intern Med. 1995;237:543–50.PubMedCrossRefGoogle Scholar
  97. 97.
    Moon JK, Yoo HS, Shibamoto T. Role of roasting conditions in the level of chlorogenic acid content in coffee beans: correlation with coffee acidity. J Agric Food Chem. 2009;57:5365–9.PubMedCrossRefGoogle Scholar
  98. 98.
    Naidoo N, Chen C, Rebello SA, et al. Cholesterol-raising diterpenes in types of coffee commonly consumed in Singapore, Indonesia and India and associations with blood lipids: a survey and cross sectional study. Nutr J. 2011;10:48.PubMedCrossRefGoogle Scholar
  99. 99.
    International Food Information Council. Caffeine and Health, Clarifying the controversies. Available at: Accessed January 2013.
  100. 100.
    Crozier TW, Stalmach A, Lean ME, Crozier A. Espresso coffees, caffeine and chlorogenic acid intake: potential health implications. Food Funct. 2012;3:30–3.PubMedCrossRefGoogle Scholar
  101. 101.
    Boekschoten MV, van Cruchten ST, Kosmeijer-Schuil TG, Katan MB. Negligible amounts of cholesterol-raising diterpenes in coffee made with coffee pads in comparison with unfiltered coffee. Ned Tijdschr Geneeskd. 2006;150:2873–5.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Saw Swee Hock School of Public HealthNational University of Singapore and National University Health SystemSingaporeSingapore
  2. 2.Saw Swee Hock School of Public Health and Department of MedicineYong Loo Lin School of Medicine, National University of Singapore and National University Health SystemSingaporeSingapore
  3. 3.Department of NutritionHarvard School of Public HealthBostonUSA

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