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Preservation of Myocardium During Coronary Artery Bypass Surgery

Current Cardiology Reports volume 14, pages 418–423 (2012)Cite this article

Abstract

Myocardial protection aims to prevent reversible post-ischemic cardiac dysfunction (myocardial stunning) and irreversible myocardial cell death (myocardial infarction) that occur as a consequence of myocardial ischemia and/or ischemic-reperfusion injury. Although the mortality rate for isolated coronary artery bypass grafting has been markedly reduced during the past decade, myocardial death, as evidenced by elevation in creatine kinase–myocardial band and/or cardiac troponin, is common. This is ascribed to suboptimal myocardial protection during cardiopulmonary bypass or with off-pump technique, early graft failure, distal embolization, and regional or global myocardial ischemia during surgery. An unmet need in contemporary coronary bypass surgery is to find more effective cardioprotective strategies that have the potential for decreasing the morbidity and mortality associated with suboptimal cardioprotection. In the present review article on myocardial protection in contemporary coronary artery bypass surgery, we attempt to elucidate the clinical problems, summarize the outcomes of selected phase III trials, and introduce new perspectives.

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  1. Division of Cardiovascular Surgery, Shiga University of Medical Science, Setatsukinowa, Otsu, 520-2192, Japan

    Takeshi Kinoshita & Tohru Asai

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  1. Takeshi Kinoshita
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Correspondence to Takeshi Kinoshita.

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Kinoshita, T., Asai, T. Preservation of Myocardium During Coronary Artery Bypass Surgery. Curr Cardiol Rep 14, 418–423 (2012). https://doi.org/10.1007/s11886-012-0271-0

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Keywords

  • Coronary artery bypass surgery
  • Myocardial protection
  • Myocardial stunning
  • Myocardial infarction
  • Off-pump technique
  • Myocardium