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Role of Intravesical Ozone in the Management of BPS/Interstitial Cystitis

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Abstract

Purpose of Review

In this review, studies and mechanisms of action relative to intravesical ozone in Bladder Pain Syndrome/Interstitial Cystitis (IC/BPS) will be summarized and correlated with pathologies of chronic pelvic pain in animal models and clinical trials.

Recent Findings

Some studies have investigated intravesical ozone therapy in view of the disadvantages of conventional interventions and the extensive popularization of ozone in healthcare.

Summary

Despite the small number of specific studies, many recent, results postulate ozone as a promising alternative for the management of IC/BPS given its antioxidant, anti-inflammatory, and immunomodulatory effect.

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Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Acknowledgements

LH Moreira, AB Fernandes, and CJ Lima acknowledge the Ânima Institute (AI). A. B. Fernandes thanks CNPq for the productivity fellowship (Process No. 310708/2021-4).

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Authors and Affiliations

  1. Biomedical Engineering Institute, Anhembi Morumbi University (UAM), Rua Casa do Ator, 275, São Paulo, SP, 04546-001, Brazil

    Maria Verônica Pires, Lívia Helena Moreira, Adriana Barrinha Fernandes & Carlos José de Lima

  2. The Federal University of Technology—Paraná (UTFPR), Via Marginal Rosalina Maria dos Santos, 1233, Bloco B, Campo Mourão, PR, 87301-899, Brazil

    Henrique Cunha Carvalho

  3. Center for Innovation, Technology, and Education (CITÉ), São José dos Campos Technological Park, Estrada Dr. Altino Bondensan, 500, São José dos Campos, SP, 12247-016, Brazil

    Henrique Cunha Carvalho, Lívia Helena Moreira, Adriana Barrinha Fernandes & Carlos José de Lima

  4. State University of Londrina (UEL), Rodovia Celso Garcia Cid, 445 Km, Campus Universitário, Londrina, PR, 86057-970, Brazil

    Lívia Helena Moreira

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  1. Maria Verônica Pires
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Pires, M.V., Carvalho, H.C., Moreira, L.H. et al. Role of Intravesical Ozone in the Management of BPS/Interstitial Cystitis. Curr Bladder Dysfunct Rep 18, 381–388 (2023). https://doi.org/10.1007/s11884-023-00716-4

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