Aquablation™: Early Clinical Results
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The treatment of lower urinary tract symptoms due to bladder outlet obstruction secondary to benign prostatic enlargement is continually evolving. Aquablation is a new ablation modality which uses a high-velocity saline stream to ablate prostatic tissue via a transurethral approach. Using robot assistance and real-time transrectal ultrasound guidance, ablation is highly targeted, and hydrodissection negates the need for thermal energy apart from electrocautery for hemostasis. Early phase I and phase II clinical trials show aquablation has a promising safety profile and clinical efficacy. There have been no significant complications in human clinical trials, including urinary incontinence and sexual function-related adverse events. A larger multi-center randomized controlled trial is currently underway to validate these early findings.
KeywordsAquablation Benign prostatic hyperplasia Ablation techniques
Compliance with Ethical Standards
Conflict of Interest
Drs Pimentel & Nair declare no conflicts of interests
Dr. Gilling reports other from Procept Biorobotics Ltd, during the conduct of the study; other from Procept Biorobotics Ltd, outside the submitted work;
Human and Animal Rights and Informed Consent
This article does not contain any studies with human or animal subjects performed by the author.
Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance
- 1.••Gilling P, Reuther R, Kahokehr A, Fraundorfer M. Aquablation–image‐guided robot‐assisted waterjet ablation of the prostate: initial clinical experience. BJU Int. 2015 (Article In Press) doi: 10.1111/bju.13358. Phase I study published showing excellent early results and safety.
- 11.•Desai M, Laddha A, Azhar RA, Mishra S, Desai M, Sabnis RR. Mp3-03 image guided robotic waterjet ablation (Aquablation) of the prostate: clinical experience of a novel technology for BPH. J Urol. 2015;4:e20. AUA Abstract 2015 Phase I Indian study of Aquablation, satisfactory results.CrossRefGoogle Scholar
- 12.•Anderson P, Mantri S, Aljuri N. Early clinical experience in Melbourne of a novel treatment for BPH: aquablation-image guided robotic waterjet ablation of the prostate. In BJU Int. 2015;115:44–5. USANZ Abstract 2015 Phase I Australian study of Aquablation, good early indicative results. Google Scholar
- 13.•Gilling P, Tan A, Anderson P. PD5-02 Multicenter experience of a novel treatment for BPH: aquablation image guided robot-assisted water jet ablation of the prostate. J Urol. 2015;193:e92–3. AUA Abstract 2015 Combined data analyses of Aquablation phase I studies conducted at different sites. CrossRefGoogle Scholar
- 15.••Clinical Trials.gov. Waterjet Ablation Therapy for Endoscopic Resection of Prostate Tissue (WATER) Study. Available from URL:https://clinicaltrials.gov/ct2/show/study/NCT02505919. Accessed 29th Nov 2015. Study design for phase III randomised controlled trial Aquablation versus TURP.