Advertisement

Current Bladder Dysfunction Reports

, Volume 10, Issue 1, pp 20–24 | Cite as

Complementary Alternative Medicine and Therapies for Overactive Bladder Symptoms: Is There Evidence for Benefit?

  • Divya ArunachalamEmail author
  • Jennifer Rothschild
Overactive Bladder (U Lee, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Overactive Bladder

Abstract

Overactive bladder is a complex syndrome that can have a significant symptomatic burden on patients. There are currently treatment options available, although these options may have significant side effects that can further diminish patients’ quality of life. The need for effective therapies that have high patient acceptability and compliance has caused many patients to seek complementary alternative forms of treatment. Herbal medications, which are used worldwide, have been shown to positively impact quality of life and provide symptomatic improvement in patients suffering with overactive bladder. Acupuncture has also been demonstrated to provide short-term relief of overactive bladder symptoms, specifically on quality of life, urgency, and frequency. Homeopathic remedies, though not widely studied, have shown to be effective in the short term for treatment of symptoms related to overactive bladder. These options may be associated with fewer side effects than traditional anti-muscarinic medications and/or surgical interventions. Further research is required to assess the true efficacy of these alternative therapeutic options.

Keywords

Overactive bladder Complementary therapy Herbal treatment Acupuncture Homeopathic remedies Alternative treatments 

Notes

Compliance with Ethics Guidelines

Conflict of Interest

Divya Arunachalam and Jennifer Rothschild declare that they have no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

References

Papers of particular interest, published recently, have been highlighted as: • Of importance,•• Of major importance

  1. 1.
    Abrams PP, Cardozo LL, Fall MM, et al. The standardisation of terminology in lower urinary tract function: report from the standardisation sub-committee of the International Continence Society. Urology. 2003;61(1):37–49. doi: 10.1016/S0090-4295(02)02243-4.CrossRefPubMedGoogle Scholar
  2. 2.
    Milsom I, Abrams P, Cardozo L, Roberts RG, Thüroff J, Wein AJ. How widespread are the symptoms of an overactive bladder and how are they managed? A population-based prevalence study. BJU Int. 2001;87(9):760–6. doi: 10.1046/j.1464-410x.2001.02228.x.CrossRefPubMedGoogle Scholar
  3. 3.
    Chancellor MB, Yoshimura N. Neurophysiology of stress urinary incontinence. Rev Urol. 2004;6 Suppl 3:S19–28.PubMedCentralPubMedGoogle Scholar
  4. 4.
    Fetscher C, Fleichman M, Schmidt M, Krege S, Michel MC. M 3muscarinic receptors mediate contraction of human urinary bladder. Br J Pharmacol. 2002;136(5):641–4. doi: 10.1038/sj.bjp.0704781.CrossRefPubMedCentralPubMedGoogle Scholar
  5. 5.•
    Chu FM, Dmochowski R. Pathophysiology of overactive bladder. Am J Med. 2006;119(3 Suppl 1):6–6. doi: 10.1016/j.amjmed.2005.12.010. Thorough overview of the pathophysiology of overactive bladder.Google Scholar
  6. 6.•
    Murphy AM, Krlin RM, Goldman HB. Treatment of overactive bladder: what is on the horizon? Int Urogynecol J. 2013;24(1):5–13. doi: 10.1007/s00192-012-1860-6. Overview of current and arising treatments for overactive bladder.CrossRefPubMedGoogle Scholar
  7. 7.
    Aizawa N, Igawa Y, Nishizawa O, Wyndaele J-J. Effects of CL316,243, a beta 3-adrenoceptor agonist, and intravesical prostaglandin E2 on the primary bladder afferent activity of the rat. Neurourol Urodyn. 2010;29(5):771–6. doi: 10.1002/nau.20826.CrossRefPubMedGoogle Scholar
  8. 8.
    Hu TW, Wagner TH. Economic considerations in overactive bladder. Am J Manag Care. 2000;6(11 Suppl):S591–8.PubMedGoogle Scholar
  9. 9.
    Stewart WF, Van Rooyen JB, Cundiff GW, et al. Prevalence and burden of overactive bladder in the United States. World J Urol. 2003;20(6):327–36. doi: 10.1007/s00345-002-0301-4.PubMedGoogle Scholar
  10. 10.
    Kay GG, Abou-Donia MB, Messer WS, Murphy DG, Tsao JW, Ouslander JG. Antimuscarinic drugs for overactive bladder and their potential effects on cognitive function in older patients. J Am Geriatr Soc. 2005;53(12):2195–201. doi: 10.1111/j.1532-5415.2005.00537.x.CrossRefPubMedGoogle Scholar
  11. 11.
    Thom DH, Haan MN, Van Den Eeden SK. Medically recognized urinary incontinence and risks of hospitalization, nursing home admission and mortality. Age Ageing. 1997;26(5):367–74. doi: 10.1093/ageing/26.5.367.CrossRefPubMedGoogle Scholar
  12. 12.
    Benner JS, Nichol MB, Rovner ES, et al. Patient-reported reasons for discontinuing overactive bladder medication. BJU Int. 2010;105(9):1276–82. doi: 10.1111/j.1464-410X.2009.09036.x.CrossRefPubMedGoogle Scholar
  13. 13.
    Rees AM. The Complementary and Alternative Medicine Information Source Book. ABC-CLIO; 2001.Google Scholar
  14. 14.
    Barnes PM, Powell-Griner E, McFann K, Nahin RL. Complementary and alternative medicine use among adults: United States, 2002. Adv Data. 2004;343:1–19.PubMedGoogle Scholar
  15. 15.••
    Chughtai B, Kavaler E, Lee R, Te A, Kaplan SA, Lowe F. Use of herbal supplements for overactive bladder. Rev Urol. 2013;15(3):93. Great overview of commonly used herbal supplements used to treat OAB.PubMedCentralPubMedGoogle Scholar
  16. 16.
    Gotoh A, Goto K, Sengoku A, et al. Inhibition of urinary bladder motility by a spinal action of U-50488H in rats. J Pharm Pharmacol. 2002;54(12):1645–50. doi: 10.1211/002235702397.CrossRefPubMedGoogle Scholar
  17. 17.
    Omiya Y, Suzuki Y, Yuzurihara M, Murata M. Antinociceptive effect of Shakuyakukanzoto, a Kampo Medicine, in Diabetic Mice. Journal of …. 2005.Google Scholar
  18. 18.
    Gotoh A, Goto K, Sengoku A, et al. Inhibition mechanism of Gosha-jinki-gan on the micturition reflex in rats. J Pharmacol Sci. 2004;96(2):115–23.CrossRefPubMedGoogle Scholar
  19. 19.
    Suzuki T, Higashi H, Saitoh K, Kurokawa K, Ohma C, Yamanaka H. Effects of gosha-jinki-gan on urinary bladder contraction in dogs. Hinyokika Kiyo. 1997;43(4):271–4.PubMedGoogle Scholar
  20. 20.
    Ogushi T, Takahashi S. Effect of Chinese herbal medicine on overactive bladder. Hinyokika Kiyo. 2007;53(12):857–62.PubMedGoogle Scholar
  21. 21.
    Kajiwara M, Mutaguchi K. Clinical efficacy and tolerability of gosha-jinki-gan, Japanese traditional herbal medicine, in females with overactive bladder. Hinyokika Kiyo. 2008;54(2):95–9.PubMedGoogle Scholar
  22. 22.
    Ito Y, Seki M, Nishioka Y, et al. Pharmacological effects of Hachi-mi-jio-gan extract (Harncare) on the contractile response and on pharmacologically relevant receptors in the rat bladder. Yakugaku Zasshi. 2009;129(8):957–64. doi: 10.1248/yakushi.129.957.CrossRefPubMedGoogle Scholar
  23. 23.
    Yoshimura K, Terai A, Arai Y. Two-week administration of low-dose Hachimi-jio-gan (Ba-Wei Di-Huang-Wan) for patients with benign prostatic hyperplasia. Hinyokika Kiyo. 2003;49(9):509–14.PubMedGoogle Scholar
  24. 24.
    Liu J, Kurashiki K, Shimizu K, Kondo R. 5alpha-reductase inhibitory effect of triterpenoids isolated from Ganoderma lucidum. Biol Pharm Bull. 2006;29(2):392–5.CrossRefPubMedGoogle Scholar
  25. 25.
    Noguchi M, Kakuma T, Tomiyasu K, et al. Effect of an extract of Ganoderma lucidum in men with lower urinary tract symptoms: a double-blind, placebo-controlled randomized and dose-ranging study. Asian J Androl. 2008;10(4):651–8. doi: 10.1111/j.1745-7262.2008.00336.x.CrossRefPubMedGoogle Scholar
  26. 26.
    Chancellor MB, de Groat WC. Intravesical capsaicin and resiniferatoxin therapy: spicing up the ways to treat the overactive bladder. J Urol. 1999;162(1):3–11. doi: 10.1097/00005392-199907000-00002.CrossRefPubMedGoogle Scholar
  27. 27.
    Lazzeri M, Beneforti P, Spinelli M, Zanollo A, Barbagli G, Turini D. Intravesical resiniferatoxin for the treatment of hypersensitive disorder: a randomized placebo controlled study. J Urol. 2000;164(3 Pt 1):676–9.CrossRefPubMedGoogle Scholar
  28. 28.
    Saitoh C, Chancellor MB, de Groat WC, Yoshimura N. Effects of intravesical instillation of resiniferatoxin on bladder function and nociceptive behavior in freely moving. Conscious rats. J Urol. 2008;179(1):359–64. doi: 10.1016/j.juro.2007.08.090.CrossRefPubMedCentralPubMedGoogle Scholar
  29. 29.
    Ojiako OA, Igwe CU. Nutritional and anti-nutritional compositions of Cleome rutidosperma, Lagenaria siceraria, and Cucurbita maxima seeds from Nigeria. J Med Food. 2007;10(4):735–8. doi: 10.1089/jmf.2007.625.CrossRefPubMedGoogle Scholar
  30. 30.
    Hata K, Tanahashi S, Wakida Y, Tatsuzaki M, Koide A. Hata: Effects of pumpkin seed extract on urinary… - Google Scholar. Med Sci …. 2005.Google Scholar
  31. 31.
    Friederich M, Theurer C, Schiebel-Schlosser G. Prosta Fink Forte capsules in the treatment of benign prostatic hyperplasia. Multicentric surveillance study in 2245 patients. Forsch Komplementarmed Klass Naturheilkd. 2000;7(4):200–4.CrossRefPubMedGoogle Scholar
  32. 32.
    Nishimura M, Ohkawara T, Sato H, Takeda H, Nishihira J. Pumpkin seed oil extracted from Cucurbita maxima improves urinary disorder in human overactive bladder. J Tradit Complement Med. 2014;4(1):72–4. doi: 10.4103/2225-4110.124355.CrossRefPubMedCentralPubMedGoogle Scholar
  33. 33.••
    Paik S-H, Han S-R, Kwon O-J, Ahn Y-M, Lee B-C, Ahn S-Y. Acupuncture for the treatment of urinary incontinence: a review of randomized controlled trials. Exp Ther Med. 2013;6(3):773–80. doi: 10.3892/etm.2013.1210. Overview of randomized control trials to date of acupuncture use for incontinence with in-depth review of their study designs, results, and limitations.PubMedCentralPubMedGoogle Scholar
  34. 34.
    Emmons SL, Otto L. Acupuncture for overactive bladder: a randomized controlled trial. Obstet Gynecol. 2005;106(1):138–43. doi: 10.1097/01.AOG.0000163258.57895.ec.CrossRefPubMedGoogle Scholar
  35. 35.
    Kelleher CJ, Filshie J, Burton G, Khullar V, Cardozo LD. Acupuncture and the treatment of irritative bladder symptoms. Acupunct Med. 1994;12(1):9–12. doi: 10.1136/aim.12.1.9.CrossRefGoogle Scholar
  36. 36.
    Engberg S, Cohen S, Sereika SM. The efficacy of acupuncture in treating urge and mixed incontinence in women: a pilot study. J Wound Ostomy Continence Nurs. 2009;36(6):661–70. doi: 10.1097/WON.0b013e3181bd82dd.CrossRefPubMedGoogle Scholar
  37. 37.
    Chernin D. The Complete Homeopathic Resource for Common Illnesses. North Atlantic Books; 2006.Google Scholar
  38. 38.
    Gollmann W. The Homoeopathic Guide in All Diseases of the Urinary and Sexual Organs. 1855.Google Scholar
  39. 39.
    van Leeuwen JHS, Castro R, Busse M, Bemelmans BL. The placebo effect in the pharmacologic treatment of patients with lower urinary tract symptoms. Eur Urol. 2006;50(3):440–53. doi: 10.1016/j.eururo.2006.05.014.CrossRefPubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  1. 1.Obstetrics and GynecologyUniversity of California DavisSacramentoUSA
  2. 2.Department of UrologyUniversity of California DavisSacramentoUSA

Personalised recommendations