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Genetic Risk Factors of Intracranial Atherosclerosis

Current Atherosclerosis Reports volume 22, Article number: 13 (2020) Cite this article

Abstract

Purpose of Review

Intracranial atherosclerosis (ICAS) is the most common cause of stroke throughout the world. It also increases the risk of recurrent stroke and dementia. As a complex and multifactorial disease, ICAS is influenced by multiple genetic, biological, and environmental factors. This review summarizes the candidate gene and genome-wide studies aimed at discovering genetic risk factors of ICAS.

Recent Findings

Numerous studies have focused on the association between single-nucleotide polymorphisms (SNPs) of atherosclerosis-related genes and the risk of ICAS. Variants in adiponectin Q (ADIPOQ), ring finger protein 213 (RNF213), apolipoprotein E (APOE), phosphodiesterase 4D (PDE4D), methylenetetrahydrofolate reductase (MTHFR), lipoprotein lipase (LPL), α-adducin (ADD1) genes, angiotensin-converting enzyme (ACE), and other genes related to renin-angiotensin-aldosterone system have been associated with ICAS.

Summary

We review the available evidences on the candidate genes and SNPs associated with genetic susceptibility to ICAS, and point out future developments of this field. Genetic discoveries could have clinical implications for intracranial atherosclerotic disease.

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  1. Department of Neurology, College of Physicians and Surgeons, Columbia University Irving Medical Center, 710 W 168th Street, 6th floor, Suite 639, New York, NY, 10032, USA

    Minghua Liu & Jose Gutierrez

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Minghua Liu has nothing to disclose. Jose Gutierrez reports grants from the NIA (NIA R01 5R01AG057709-02) during the conduct of the study.

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Liu, M., Gutierrez, J. Genetic Risk Factors of Intracranial Atherosclerosis. Curr Atheroscler Rep 22, 13 (2020). https://doi.org/10.1007/s11883-020-0831-5

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Keywords

  • Intracranial atherosclerosis
  • Genetic factor
  • Genome-wide association study
  • Adiponectin Q
  • Ring finger protein 213