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The Role of Ezetimibe in the Treatment of Cardiovascular Disease

  • Coronary Heart Disease (S. Virani and S. Naderi, Section Editors)
  • Published:
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Abstract

Cardiovascular disease (CVD) is the leading cause of morbidity and mortality worldwide. Despite the success of treatment of CVD with statin therapy, a number of patients remain at high risk for CVD. Ezetimibe is a non-statin agent that inhibits intestinal cholesterol absorption, leading to reductions in low-density lipoprotein cholesterol (LDL-C). A number of clinical studies evaluating the use of ezetimibe therapy have resulted in discordant data regarding its safety and efficacy. In this review, we discuss the findings from these studies as well as potential indications for the use of ezetimibe for LDL-C lowering and cardiovascular event reduction.

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Correspondence to Salim S. Virani.

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Anandita Agarwala, Zaid Kajani, Michael D. Miedema, and Salim S. Virani declare that they have no conflict of interest.

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This article does not contain any studies with human or animal subjects performed by any of the authors.

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This article is part of the Topical Collection on Coronary Heart Disease

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Agarwala, A., Kajani, Z., Miedema, M.D. et al. The Role of Ezetimibe in the Treatment of Cardiovascular Disease. Curr Atheroscler Rep 18, 8 (2016). https://doi.org/10.1007/s11883-016-0560-y

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  • DOI: https://doi.org/10.1007/s11883-016-0560-y

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