Vitamin D, Calcium, and Atherosclerotic Risk: Evidence from Serum Levels and Supplementation Studies

  • Pamela L. Lutsey
  • Erin D. Michos
Nonstatin Drugs (WB Borden, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Nonstatin Drugs


Vitamin D and calcium have traditionally been viewed in relation to bone health. However, recent research has suggested relations between these nutrients and cardiovascular disease (CVD). Specifically, evidence from both observational studies and clinical trials suggests that vitamin D may be related to lower risk of CVD. The picture for calcium is more complex. Dietary intake of calcium may be associated with lower CVD risk, while calcium supplementation may elevate CVD risk. In this review, we summarize evidence of these relations, and comment on the recent Institute of Medicine (IOM) recommendations regarding use of vitamin D and calcium supplements.


Calcium Vitamin D Supplements Cardiovascular disease Review 



The authors report no financial conflicts of interest with commercial entities. Drs. Michos and Lutsey are supported by grants from NIH/NINDS (1 R01 NS072243-01) and NIH/NHLBI (R01 HL103706).


Papers of particular interest, published recently, have been highlighted as: •• Of major importance

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© Springer Science+Business Media New York 2012

Authors and Affiliations

  1. 1.Division of Epidemiology and Community HealthUniversity of MinnesotaMinneapolisUSA
  2. 2.Division of CardiologyJohns Hopkins University School of MedicineBaltimoreUSA

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