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Gastrointestinal Surgery for Obesity and Diabetes: Weight Loss and Control of Hyperglycemia

  • Lipid and Metabolic Effects of Gastrointestinal Surgery (F Rubino, Section Editor)
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Abstract

Obesity is associated with a variety of weight-related metabolic comorbidities. Bariatric surgery (metabolic/gastrointestinal surgery) not only achieves significant and sustainable weight loss, but also induces extraordinary effects on nearly all obesity-related comorbidities, particularly remission of type 2 diabetes mellitus (T2DM). The mechanisms underlying such effects are slowly being elucidated, and it appears that the metabolic benefits of bariatric surgery are not only attributable to weight loss, but there are also weight independent mechanisms at play. This article outlines the metabolic effects of the most commonly performed bariatric procedures, with a particular emphasis on how they affect glucose metabolism and T2DM.

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Disclosure

HM Heneghan; none; S. Nissen: Vivus and Orexigen, clinical trial support; PR Schauer: Board membership to Ethicon Endosurgery, Surgiquest, Barosense, RemedyMD; and Stryker, consultancy for Ethicon Endosurgery, Stryker, Gore, and Carefusion, provided expert testimony to Physicians Review of Surgery, LLC, received payment for lectures from Ethicon Endosurgery, Cinemed, and Quadrant Healthcare, has stock/stock options with Intuitive Surgical, Inc, Barosense, Surgiquest, and ReMedyMD.

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  1. Bariatric and Metabolic Institute, M61, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH, 44195, USA

    H. M. Heneghan & P. R. Schauer

  2. Heart & Vascular Institute, Cleveland Clinic, Cleveland, OH, USA

    S. Nissen

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  1. H. M. Heneghan
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  2. S. Nissen
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  3. P. R. Schauer
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Correspondence to P. R. Schauer.

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Heneghan, H.M., Nissen, S. & Schauer, P.R. Gastrointestinal Surgery for Obesity and Diabetes: Weight Loss and Control of Hyperglycemia. Curr Atheroscler Rep 14, 579–587 (2012). https://doi.org/10.1007/s11883-012-0285-5

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