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Metabolic syndrome

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Abstract

The metabolic syndrome is like an elephant, and any literary review of its importance is shamefully reduced to an examination of tusks, trunk, and tail. Evidence continues to mount that this diminutive approach is an incorrect management strategy for such a large problem. Diet and lifestyle are effective strategies, but they must effectively compete with behaviors that have instant gratification. Our society has turned its focus away from the long-term rewards of good sustainable behaviors and has instead focused on short-term rewards of unsustainable behaviors. To tame the behaviors that promote the metabolic syndrome, simple answers from diet and drug therapy will require support from society to be effective.

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References and Recommended Reading

  1. Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults: Executive summary of the third report of the National Cholesterol Education Program (NCEP) Expert Panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III). JAMA 2001, 285:2486–2497.

    Article  Google Scholar 

  2. Ford ES, Giles WH, Dietz WH: Prevalence of the metabolic syndrome among US adults: findings from the third National Health and Nutrition Examination Survey. JAMA 2002, 287:356–359.

    Article  PubMed  Google Scholar 

  3. Costa A, Iguala I, Bedini J, et al.: Uric acid concentration in subjects at risk of type 2 diabetes mellitus: relationship to components of the metabolic syndrome. Metabolism 2002, 51:372–375.

    Article  PubMed  CAS  Google Scholar 

  4. Frayn KN: Adipose tissue and the insulin resistance syndrome. Proc Nutr Soc 2001, 60:375–380.

    Article  PubMed  CAS  Google Scholar 

  5. Unger RH: Lipotoxic diseases. Ann Rev Med 2002, 53:319–336.

    Article  PubMed  CAS  Google Scholar 

  6. Chitturi S, Abeygunasekera S, Farrell GC, et al.: NASH and insulin resistance: insulin hypersecretion and specific association with the insulin resistance syndrome. Hepatology 2002, 35:373–379.

    Article  PubMed  CAS  Google Scholar 

  7. Hodge AM, Boyko EJ, de Courten M, et al.: Leptin and other components of the Metabolic Syndrome in Mauritius—a factor analysis. Int J Obes 2001, 25:126–131.

    Article  CAS  Google Scholar 

  8. Hsueh WA, Law RE: PPARgamma and atherosclerosis: effects on cell growth and movement. Arterioscler Thromb Vasc Biol 2001, 21:1891–1895.

    PubMed  CAS  Google Scholar 

  9. Kaplan F, Al-Majali K, Betteridge DJ: PPARS, insulin resistance and type 2 diabetes. J Cardiovasc Risk 2001, 8:211–217.

    Article  PubMed  CAS  Google Scholar 

  10. Moller DE: New drug targets for type 2 diabetes and the metabolic syndrome. Nature 2001, 414:821–827.

    Article  PubMed  CAS  Google Scholar 

  11. Rodriguez-Moran M, Guerrero-Romero F: The parental phenotype of diabetes, but not of essential hypertension, is linked to the development of metabolic syndrome. Acta Diabetol 2001, 38:87–91.

    Article  PubMed  CAS  Google Scholar 

  12. Araneta MR, Wingard DL, Barrett-Connor E: Type 2 diabetes and metabolic syndrome in Filipina-American women: a high-risk nonobese population. Diabetes Care 2002, 25:494–499.

    Article  PubMed  Google Scholar 

  13. Busetto L: Visceral obesity and the metabolic syndrome: effects of weight loss. Nutr Metab Cardiovasc Dis 2001, 11:195–204.

    PubMed  CAS  Google Scholar 

  14. Ip MS, Lam B, Ng MM, et al.: Obstructive sleep apnea is independently associated with insulin resistance. Am J Respir Crit Care Med 2002, 165:670–676.

    PubMed  Google Scholar 

  15. Pagano G, Pacini G, Musso G, et al.: Nonalcoholic steatohepatitis, insulin resistance, and metabolic syndrome: further evidence for an etiologic association. Hepatology 2002, 35:367–372.

    Article  PubMed  CAS  Google Scholar 

  16. Pannacciulli N, Cantatore FP, Minenna A, et al.: C-reactive protein is independently associated with total body fat, central fat, and insulin resistance in adult women. Int J Obes 2001, 25:1416–1420.

    Article  CAS  Google Scholar 

  17. Sinaiko AR, Jacobs DR Jr, Steinberger J, et al.: Insulin resistance syndrome in childhood: associations of the euglycemic insulin clamp and fasting insulin with fatness and other risk factors. J Pediatr 2001, 139:700–707.

    Article  PubMed  CAS  Google Scholar 

  18. Poppitt SD, Keogh GF, Prentice AM, et al.: Long-term effects of ad libitum low-fat, high-carbohydrate diets on body weight and serum lipids in overweight subjects with metabolic syndrome. Am J Clin Nutr 2002, 75:11–20.

    PubMed  CAS  Google Scholar 

  19. Goude D, Fagerberg B, Hulthe J, for the AIR Study Group: Alcohol consumption, the metabolic syndrome and insulin resistance in 58-year-old clinically healthy men (AIR study). Clin Sci 2002, 102:345–352.

    Article  PubMed  Google Scholar 

  20. Dixon JB, Dixon ME, O’Brien PE: Alcohol consumption in the severely obese: relationship with the metabolic syndrome. Obes Res 2002, 10:245–252.

    Article  PubMed  Google Scholar 

  21. Wirfalt E, Hedblad B, Gullberg B, et al.: Food patterns and components of the metabolic syndrome in men and women: a cross-sectional study within the Malmo Diet and Cancer cohort. Am J Epidemiol 2001, 154:1150–1159.

    Article  PubMed  CAS  Google Scholar 

  22. Pereira MA, Jacobs DR Jr, Van Horn L, et al.: Dairy consumption, obesity, and the insulin resistance syndrome in young adults: the CARDIA Study. JAMA 2002, 287:2081–2089.

    Article  PubMed  Google Scholar 

  23. Appel LJ, Moore TJ, Obarzanek E, et al.: A clinical trial of the effects of dietary patterns on blood pressure. DASH Collaborative Research Group. N Engl J Med 1997, 336:1117–1124.

    Article  PubMed  CAS  Google Scholar 

  24. Zimmet P, Alberti KG, Shaw J: Global and societal implications of the diabetes epidemic. Nature 2001, 414:782–787.

    Article  PubMed  CAS  Google Scholar 

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Denke, M.A. Metabolic syndrome. Curr Atheroscler Rep 4, 444–447 (2002). https://doi.org/10.1007/s11883-002-0048-9

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  • DOI: https://doi.org/10.1007/s11883-002-0048-9

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