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Prevention of restenosis with intravascular beta-radiotherapy

Current Atherosclerosis Reports volume 3, pages 169–173 (2001)Cite this article

Abstract

Beta radiation has been clearly shown, in a specific dose range, to be highly effective in the inhibition of the restenotic process after balloon or stent injury in animal experiments, as well as in randomized, placebo-controlled human trials. The major advantage of beta radiation, in comparison with gamma radiation, is a significantly lower radiation exposure to the personnel and patient, and easier adaptability to existing cardiac catheterization laboratories. Rapidly accumulating evidence indicates that the two major problems, late thrombosis and edge stenosis, may be minimized with prolonged antiplatelet therapy (6 months or more) and broader radiation coverage of the intervention site. Although there may be better, safer, and easier options to reduce restenosis in the years to come, intravascular radiotherapy is the first breakthrough modality that has been shown to significantly reduce restenosis after percutaneous vascular interventions.

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Affiliations

  1. The Methodist DeBakey Heart Center and Section of Cardiology, Department of Medicine, Baylor College of Medicine, 6535 Fannin, Room FB 1034, 77030, Houston, TX, USA

    Grzegorz L. Kaluza MD, PhD, Pawel T. Zymek MD & Albert E. Raizner MD

Authors
  1. Grzegorz L. Kaluza MD, PhD
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  2. Pawel T. Zymek MD
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  3. Albert E. Raizner MD
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Kaluza, G.L., Zymek, P.T. & Raizner, A.E. Prevention of restenosis with intravascular beta-radiotherapy. Curr Atheroscler Rep 3, 169–173 (2001). https://doi.org/10.1007/s11883-001-0054-3

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  • DOI: https://doi.org/10.1007/s11883-001-0054-3

Keywords

  • Radiat Oncol Biol Phys
  • Target Lesion Revascularization
  • Restenosis Rate
  • Beta Radiation
  • Late Thrombosis