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Vitamin D and Otitis Media

Abstract

Purpose of Review

To examine the relationship between vitamin D and otitis media.

Recent Findings

Vitamin D deficiency has been associated with several respiratory diseases, including otitis media. Vitamin D supplementation may reduce the risk of otitis media. This relationship may be explained by vitamin D supporting the immune system by upregulating antimicrobial peptides which are effective against otopathogens and biofilm formation, supporting a less inflammatory immune response, or promoting beneficial commensal bacteria.

Summary

This review will explore risk factors of both otitis media and vitamin D deficiency, the evidence of vitamin D being beneficial for various forms of otitis media, and possible mechanisms of action.

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Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Walker, R.E., Bartley, J., Camargo, C.A. et al. Vitamin D and Otitis Media. Curr Allergy Asthma Rep 19, 33 (2019). https://doi.org/10.1007/s11882-019-0866-2

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Keywords

  • Otitis media
  • Vitamin D
  • Viral infections
  • Respiratory microbiota
  • Antimicrobial peptides
  • Cytokines
  • Biofilms
  • Upper respiratory tract infections