Abstract
Purpose of Review
To familiarize the reader with the concept of precision medicine in food allergy by dealing with the current biomarkers for the diagnosis, prognosis, and management of the disease.
Recent Findings
Many efforts have been devoted in order to characterize reliable biomarkers able to identify specific phenotypes and endotypes in food allergy. Specific IgE (sIgE), sIgE/total IgE ratios, and T cell assays are just a few candidates that have been investigated over time. With the advent of omics sciences, a new era is commencing. A better understanding of pathogenesis of food allergy and mechanisms of action of the different therapeutic options will allow the accurate selection of the appropriate patient.
Summary
In the near future, advances in technologies and data interpretation will allow a better understanding of the pathogenesis of food allergy and the identification of proper biomarkers for a personalized treatment tailored on the specific patient’s profile.
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Abbreviations
- BAT:
-
basophil activation test
- CM:
-
cow’s milk
- FA:
-
IgE-mediated food allergy
- FEV1/FVC:
-
forced expiratory volume in one second/forced vital capacity
- HE:
-
hen’s egg
- IEC:
-
intestinal epithelial cell
- LR:
-
likelihood ratio
- LTP:
-
lipid transfer proteins
- MAT:
-
mast cell activation test
- MD:
-
molecular diagnostics
- MS:
-
mass spectrometry
- NPV:
-
negative predictive value
- OFC:
-
oral food challenge
- OIT:
-
oral immunotherapy
- PA:
-
peanut allergy
- PR-10:
-
pathogenesis-related protein-10
- PPV:
-
positive predictive value
- sIgE:
-
specific immunoglobulin E
- SPT:
-
skin prick test
- Treg:
-
regulatory T cell
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Muraro, A., Arasi, S. Biomarkers in Food Allergy. Curr Allergy Asthma Rep 18, 64 (2018). https://doi.org/10.1007/s11882-018-0816-4
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DOI: https://doi.org/10.1007/s11882-018-0816-4