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Biomarkers in Food Allergy

  • Food Allergy (T Green, Section Editor)
  • Published:
Current Allergy and Asthma Reports Aims and scope Submit manuscript

Abstract

Purpose of Review

To familiarize the reader with the concept of precision medicine in food allergy by dealing with the current biomarkers for the diagnosis, prognosis, and management of the disease.

Recent Findings

Many efforts have been devoted in order to characterize reliable biomarkers able to identify specific phenotypes and endotypes in food allergy. Specific IgE (sIgE), sIgE/total IgE ratios, and T cell assays are just a few candidates that have been investigated over time. With the advent of omics sciences, a new era is commencing. A better understanding of pathogenesis of food allergy and mechanisms of action of the different therapeutic options will allow the accurate selection of the appropriate patient.

Summary

In the near future, advances in technologies and data interpretation will allow a better understanding of the pathogenesis of food allergy and the identification of proper biomarkers for a personalized treatment tailored on the specific patient’s profile.

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Abbreviations

BAT:

basophil activation test

CM:

cow’s milk

FA:

IgE-mediated food allergy

FEV1/FVC:

forced expiratory volume in one second/forced vital capacity

HE:

hen’s egg

IEC:

intestinal epithelial cell

LR:

likelihood ratio

LTP:

lipid transfer proteins

MAT:

mast cell activation test

MD:

molecular diagnostics

MS:

mass spectrometry

NPV:

negative predictive value

OFC:

oral food challenge

OIT:

oral immunotherapy

PA:

peanut allergy

PR-10:

pathogenesis-related protein-10

PPV:

positive predictive value

sIgE:

specific immunoglobulin E

SPT:

skin prick test

Treg:

regulatory T cell

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Authors and Affiliations

  1. Department of Woman and Child Health, Referral Centre for Food Allergy Diagnosis and Treatment Veneto Region, University of Padua, Via Giustiniani 3, 35128, Padua, Italy

    Antonella Muraro

  2. Allergy Unit, Bambino Gesù Children’s Hospital, IRCCS, Piazza Sant’Onofrio 4, 00165, Rome, Italy

    Stefania Arasi

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  1. Antonella Muraro
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Correspondence to Antonella Muraro.

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This article is part of the Topical Collection on Food Allergy

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Muraro, A., Arasi, S. Biomarkers in Food Allergy. Curr Allergy Asthma Rep 18, 64 (2018). https://doi.org/10.1007/s11882-018-0816-4

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