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The Genetics of Food Allergy

  • Cristina A. Carter
  • Pamela A. Frischmeyer-GuerrerioEmail author
Food Allergy (T Green, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Food Allergy

Abstract

Purpose of Review

Food allergy likely arises from a complex interplay between environmental triggers and genetic susceptibility. Here, we review recent studies that have investigated the genetic pathways and mechanisms that may contribute to the pathogenesis of food allergy.

Recent Findings

A heritability component of food allergy has been observed in multiple studies. A number of monogenic diseases characterized by food allergy have elucidated pathways that may be important in pathogenesis. Several population-based genetic variants associated with food allergy have also been identified.

Summary

The genetic mechanisms that play a role in the development of food allergy are heterogeneous and complex. Advances in our understanding of the genetics of food allergy, and how this predisposition interacts with environmental exposures to lead to disease, will improve our understanding of the key pathways leading to food allergy and inform more effective prevention and treatment strategies.

Keywords

Food allergy Genetic variants Heritability Monogenic disorders Allergy mechanism 

Notes

Acknowledgements

This research was supported by the Intramural Research Program of the National Institute of Allergy and Infectious Diseases, NIH.

Compliance with Ethical Standards

Conflicts of Interest

The authors declare no conflicts of interest relevant to this manuscript.

Human and Animal Rights

All reported studies/experiments with human or animal subjects performed by the authors have been previously published and complied with all applicable ethical standards (including the Helsinki declaration and its amendments, institutional/national research committee standards, and international/national/institutional guidelines).

References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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© This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2018

Authors and Affiliations

  • Cristina A. Carter
    • 1
  • Pamela A. Frischmeyer-Guerrerio
    • 2
    Email author
  1. 1.Vaccine Research Center, NIAIDNational Institutes of HealthBethesdaUSA
  2. 2.Laboratory of Allergic Diseases, NIAIDNational Institutes of HealthBethesdaUSA

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