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Mitochondrial Function in Allergic Disease

  • Basic and Applied Science (I Lewkowich, Section Editor)
  • Published:
Current Allergy and Asthma Reports Aims and scope Submit manuscript

Abstract

Purpose of the Review

The connections between allergy, asthma and metabolic syndrome are becoming increasingly clear. Recent research suggests a unifying mitochondrial link between the diverse phenotypes of these interlinked morbidities. The scope of this review is to highlight cellular mechanisms, epidemiology and environmental allergens influencing mitochondrial function and its importance in allergy and asthma. We briefly also consider the potential of mitochondria-targeted therapies in prevention and cure.

Recent Findings

Recent research has shown allergy, asthma and metabolic syndrome to be linked to mitochondrial dysfunction. Environmental pollutants and allergens are observed to cause mitochondrial dysfunction, primarily by inducing oxidative stress and ROS production. Malfunctioning mitochondria change the bioenergetics of the cell and its metabolic profile to favour systemic inflammation, which drives all three types of morbidities.

Summary

Given the existing experimental evidence, approaches targeting mitochondria (e.g. antioxidant therapy and mitochondrial replacement) are being conducted in relevant disease models—with some progressing towards clinical trials, making mitochondrial function the focus of translational therapy research in asthma, allergy and linked metabolic syndrome.

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Abbreviations

AIM2 :

Absent in melanoma 2

BAL :

Bronchoalveolar lavage

DrpI :

Dynamin 1 like protein

ETC :

Electron transport chain

IFN :

Interferon Gamma

IgE :

Immunoglobulin E

IL :

Interleukin

KDa :

Kilodalton

NLRP3 :

Nod Like receptor family pyrin domain containing 3

OpaI :

Optic Atrophy 1

PGC 1α :

Peroxisome proliferator-activated receptor gamma coactivator 1 alpha

ROS :

Reactive oxygen species

TET :

Ten-eleven translocation

TFAM :

Transcription Factor A Mitochondrial

Th2 :

T helper cells type 2

TNFα :

Tumour Necrosis Factor Alpha

References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

  1. Strachan DP. The role of environmental factors in asthma. Br Med Bull. 2000;56(4):865–82.

    Article  CAS  PubMed  Google Scholar 

  2. Agrawal A, Mabalirajan U, Ahmad T, Ghosh B. Emerging interface between metabolic syndrome and asthma. Am J Respir Cell Mol Biol. 2011;44(3):270–5. doi:10.1165/rcmb.2010-0141TR.

    Article  CAS  PubMed  Google Scholar 

  3. Kent BD, Lane SJ. Twin epidemics: asthma and obesity. Int Arch Allergy Immunol. 2012;157(3):213–4. doi:10.1159/000329874.

    Article  PubMed  Google Scholar 

  4. Perez MK, Piedimonte G. Metabolic asthma: is there a link between obesity, diabetes, and asthma? Immunol Allergy Clin N Am. 2014;34(4):777–84. doi:10.1016/j.iac.2014.07.002.

    Article  Google Scholar 

  5. Tedeschi A, Airaghi L. Is affluence a risk factor for bronchial asthma and type 1 diabetes? Pediatr Allergy Immunol. 2006;17(7):533–7. doi:10.1111/j.1399-3038.2006.00445.x.

    Article  PubMed  Google Scholar 

  6. •• James AM, Collins Y, Logan A, Murphy MP. Mitochondrial oxidative stress and the metabolic syndrome. Trends Endocrinol Metab. 2012;23(9):429–34. doi:10.1016/j.tem.2012.06.008. A detailed review on the biochemical mechanisms linking mitochondrial ROS, mitochondrial dysfunction, systemic inflammation and metabolic syndrome

    Article  CAS  PubMed  Google Scholar 

  7. Bach JF. The effect of infections on susceptibility to autoimmune and allergic diseases. N Engl J Med. 2002;347(12):911–20. doi:10.1056/NEJMra020100.

    Article  PubMed  Google Scholar 

  8. Strachan DP. Family size, infection and atopy: the first decade of the "hygiene hypothesis". Thorax. 2000;55(Suppl 1):S2–10.

    Article  PubMed  PubMed Central  Google Scholar 

  9. • Beggs PJ, Bambrick HJ. Is the global rise of asthma an early impact of anthropogenic climate change? Environ Health Perspect. 2005;113(8):915–9. New insight into increased persistence of environmental allergens due to climate changes

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Hong EE, Okitsu CY, Smith AD, Hsieh CL. Regionally specific and genome-wide analyses conclusively demonstrate the absence of CpG methylation in human mitochondrial DNA. Mol Cell Biol. 2013;33(14):2683–90. doi:10.1128/MCB.00220-13.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Smith AE, Marcker KA. N-formylmethionyl transfer RNA in mitochondria from yeast and rat liver. J Mol Biol. 1968;38(2):241–3.

    Article  CAS  PubMed  Google Scholar 

  12. Daum G. Lipids of mitochondria. Biochim Biophys Acta. 1985;822(1):1–42.

    Article  CAS  PubMed  Google Scholar 

  13. Arnoult D, Soares F, Tattoli I, Girardin SE. Mitochondria in innate immunity. EMBO Rep. 2011;12(9):901–10. doi:10.1038/embor.2011.157.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Zhang Q, Raoof M, Chen Y, Sumi Y, Sursal T, Junger W, et al. Circulating mitochondrial DAMPs cause inflammatory responses to injury. Nature. 2010;464(7285):104–7. doi:10.1038/nature08780.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Chen GY, Nunez G. Sterile inflammation: sensing and reacting to damage. Nat Rev Immunol. 2010;10(12):826–37. doi:10.1038/nri2873.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  16. Schwacha MG, Rani M, Zhang Q, Nunez-Cantu O, Cap AP. Mitochondrial damage-associated molecular patterns activate gammadelta T-cells. Innate Immun. 2014;20(3):261–8. doi:10.1177/1753425913488969.

    Article  PubMed  Google Scholar 

  17. Idzko M, Hammad H, van Nimwegen M, Kool M, Willart MA, Muskens F, et al. Extracellular ATP triggers and maintains asthmatic airway inflammation by activating dendritic cells. Nat Med. 2007;13(8):913–9. doi:10.1038/nm1617.

    Article  CAS  PubMed  Google Scholar 

  18. Lommatzsch M, Cicko S, Muller T, Lucattelli M, Bratke K, Stoll P, et al. Extracellular adenosine triphosphate and chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2010;181(9):928–34. doi:10.1164/rccm.200910-1506OC.

    Article  CAS  PubMed  Google Scholar 

  19. Kouzaki H, Iijima K, Kobayashi T, O'Grady SM, Kita H. The danger signal, extracellular ATP, is a sensor for an airborne allergen and triggers IL-33 release and innate Th2-type responses. J Immunol. 2011;186(7):4375–87. doi:10.4049/jimmunol.1003020.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  20. Lohman AW, Billaud M, Isakson BE. Mechanisms of ATP release and signalling in the blood vessel wall. Cardiovasc Res. 2012;95(3):269–80. doi:10.1093/cvr/cvs187.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  21. Grygorczyk R, Hanrahan JW. CFTR-independent ATP release from epithelial cells triggered by mechanical stimuli. Am J Phys. 1997;272(3 Pt 1):C1058–66.

    CAS  Google Scholar 

  22. Hazama A, Shimizu T, Ando-Akatsuka Y, Hayashi S, Tanaka S, Maeno E, Okada Y. Swelling-induced, CFTR-independent ATP release from a human epithelial cell line: lack of correlation with volume-sensitive cl(−) channels. J Gen Physiol. 1999;114(4):525–33.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  23. Loomis WH, Namiki S, Ostrom RS, Insel PA, Junger WG. Hypertonic stress increases T cell interleukin-2 expression through a mechanism that involves ATP release, P2 receptor, and p38 MAPK activation. J Biol Chem. 2003;278(7):4590–6. doi:10.1074/jbc.M207868200.

    Article  CAS  PubMed  Google Scholar 

  24. Collins LV, Hajizadeh S, Holme E, Jonsson IM, Tarkowski A. Endogenously oxidized mitochondrial DNA induces in vivo and in vitro inflammatory responses. J Leukoc Biol. 2004;75(6):995–1000. doi:10.1189/jlb.0703328.

    Article  CAS  PubMed  Google Scholar 

  25. Akira S, Takeda K. Toll-like receptor signalling. Nat Rev Immunol. 2004;4(7):499–511. doi:10.1038/nri1391.

    Article  CAS  PubMed  Google Scholar 

  26. Nakahira K, Haspel JA, Rathinam VA, Lee SJ, Dolinay T, Lam HC, et al. Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome. Nat Immunol. 2011;12(3):222–30. doi:10.1038/ni.1980.

    Article  CAS  PubMed  Google Scholar 

  27. Shimada K, Crother TR, Karlin J, Dagvadorj J, Chiba N, Chen S, et al. Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis. Immunity. 2012;36(3):401–14. doi:10.1016/j.immuni.2012.01.009.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  28. Shaham O, Slate NG, Goldberger O, Xu Q, Ramanathan A, Souza AL, et al. A plasma signature of human mitochondrial disease revealed through metabolic profiling of spent media from cultured muscle cells. Proc Natl Acad Sci U S A. 2010;107(4):1571–5. doi:10.1073/pnas.0906039107.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  29. Rubic T, Lametschwandtner G, Jost S, Hinteregger S, Kund J, Carballido-Perrig N, et al. Triggering the succinate receptor GPR91 on dendritic cells enhances immunity. Nat Immunol. 2008;9(11):1261–9. doi:10.1038/ni.1657.

    Article  CAS  PubMed  Google Scholar 

  30. Tannahill GM, Curtis AM, Adamik J, Palsson-McDermott EM, McGettrick AF, Goel G, et al. Succinate is an inflammatory signal that induces IL-1beta through HIF-1alpha. Nature. 2013;496(7444):238–42. doi:10.1038/nature11986.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  31. Ksenzenko SM, Davidson SB, Saba AA, Franko AP, Raafat AM, Diebel LN, Dulchavsky SA. Effect of triiodothyronine augmentation on rat lung surfactant phospholipids during sepsis. J Appl Physiol. 1997;82(6):2020–7.

    CAS  PubMed  Google Scholar 

  32. Liau DF, Barrett CR, Bell AL, Cernansky G, Ryan SF. Diphosphatidylglycerol in experimental acute alveolar injury in the dog. J Lipid Res. 1984;25(7):678–83.

    CAS  PubMed  Google Scholar 

  33. Iyer SS, He Q, Janczy JR, Elliott EI, Zhong Z, Olivier AK, et al. Mitochondrial cardiolipin is required for Nlrp3 inflammasome activation. Immunity. 2013;39(2):311–23. doi:10.1016/j.immuni.2013.08.001.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  34. Chakraborty K, Raundhal M, Chen BB, Morse C, Tyurina YY, Khare A, et al. The mito-DAMP cardiolipin blocks IL-10 production causing persistent inflammation during bacterial pneumonia. Nat Commun. 2017;8:13944. doi:10.1038/ncomms13944.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  35. Boulay F, Tardif M, Brouchon L, Vignais P. The human N-formylpeptide receptor. Characterization of two cDNA isolates and evidence for a new subfamily of G-protein-coupled receptors. Biochemistry. 1990;29(50):11123–33.

    Article  CAS  PubMed  Google Scholar 

  36. Panaro MA, Acquafredda A, Sisto M, Lisi S, Maffione AB, Mitolo V. Biological role of the N-formyl peptide receptors. Immunopharmacol Immunotoxicol. 2006;28(1):103–27. doi:10.1080/08923970600625975.

    Article  CAS  PubMed  Google Scholar 

  37. Crouser ED, Shao G, Julian MW, Macre JE, Shadel GS, Tridandapani S, et al. Monocyte activation by necrotic cells is promoted by mitochondrial proteins and formyl peptide receptors. Crit Care Med. 2009;37(6):2000–9. doi:10.1097/CCM.0b013e3181a001ae.

  38. •• Aguilera-Aguirre L, Bacsi A, Saavedra-Molina A, Kurosky A, Sur S, Boldogh I. Mitochondrial dysfunction increases allergic airway inflammation. J Immunol. 2009;183(8):5379–87. doi:10.4049/jimmunol.0900228. The first experimental study to conclusively show that mitochondrial dysfunction promotes allergic inflammation

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  39. Kaminski MM, Sauer SW, Klemke CD, Suss D, Okun JG, Krammer PH, Gulow K. Mitochondrial reactive oxygen species control T cell activation by regulating IL-2 and IL-4 expression: mechanism of ciprofloxacin-mediated immunosuppression. J Immunol. 2010;184(9):4827–41. doi:10.4049/jimmunol.0901662.

    Article  CAS  PubMed  Google Scholar 

  40. Kim SR, Kim DI, Kim SH, Lee H, Lee KS, Cho SH, Lee YC. NLRP3 inflammasome activation by mitochondrial ROS in bronchial epithelial cells is required for allergic inflammation. Cell Death Dis. 2014;5:e1498. doi:10.1038/cddis.2014.460.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  41. Pattnaik B, Bodas M, Bhatraju NK, Ahmad T, Pant R, Guleria R, et al. IL-4 promotes asymmetric dimethylarginine accumulation, oxo-nitrative stress, and hypoxic response-induced mitochondrial loss in airway epithelial cells. J Allergy Clin Immunol. 2016;138(1):130–41 e9. doi:10.1016/j.jaci.2015.11.036.

    Article  CAS  PubMed  Google Scholar 

  42. Reddy PH. Mitochondrial dysfunction and oxidative stress in asthma: implications for mitochondria-targeted antioxidant therapeutics. Pharmaceuticals (Basel). 2011;4(3):429–56. doi:10.3390/ph4030429.

    Article  CAS  Google Scholar 

  43. Raj D, Kabra SK, Lodha R. Childhood obesity and risk of allergy or asthma. Immunol Allergy Clin N Am. 2014;34(4):753–65. doi:10.1016/j.iac.2014.07.001.

    Article  Google Scholar 

  44. Pedersen PA, Weeke ER. Asthma and allergic rhinitis in the same patients. Allergy. 1983;38(1):25–9.

    Article  CAS  PubMed  Google Scholar 

  45. • Qi S, Barnig C, Charles AL, Poirot A, Meyer A, Clere-Jehl R, et al. Effect of nasal allergen challenge in allergic rhinitis on mitochondrial function of peripheral blood mononuclear cells. Ann Allergy Asthma Immunol. 2017;118(3):367–9. doi:10.1016/j.anai.2016.11.026. First report linking allergic rhinitis with systemic inflammation

    Article  CAS  PubMed  Google Scholar 

  46. Cahoon JM VA. Endoplasmic reticulum—mitochondrial interactions in house dust mite induced inflammation: UVM College of Arts and Sciences College; 2015.

  47. Hosoki K, Boldogh I, Sur S. Innate responses to pollen allergens. Curr Opin Allergy Clin Immunol. 2015;15(1):79–88. doi:10.1097/ACI.0000000000000136.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  48. Singh VP, Aggarwal R, Singh S, Banik A, Ahmad T, Patnaik BR, et al. Metabolic syndrome is associated with increased oxo-nitrative stress and asthma-like changes in lungs. PLoS One. 2015;10(6):e0129850. doi:10.1371/journal.pone.0129850.

    Article  PubMed  PubMed Central  Google Scholar 

  49. Raby BA, Klanderman B, Murphy A, Mazza S, Camargo Jr CA, Silverman EK, Weiss ST. A common mitochondrial haplogroup is associated with elevated total serum IgE levels. J Allergy Clin Immunol. 2007;120(2):351–8. doi:10.1016/j.jaci.2007.05.029.

    Article  CAS  PubMed  Google Scholar 

  50. Takizawa H. Impact of air pollution on allergic diseases. Korean J Intern Med. 2011;26(3):262–73. doi:10.3904/kjim.2011.26.3.262.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  51. Ikeda YSS, Nagarajan N, Rubattu S, Volpe M, Frati G, Sadoshima J. New insights into the role of mitochondrial dynamics and autophagy during oxidative stress and aging in the heart. Oxidative Med Cell Longev. 2014;2014 doi:10.1155/2014/210934. Review on the associations between mitochondrial dynamics, mitophagy, oxidative stress and aging

  52. Li R, Kou X, Geng H, Xie J, Yang Z, Zhang Y, et al. Effect of ambient PM(2.5) on lung mitochondrial damage and fusion/fission gene expression in rats. Chem Res Toxicol. 2015;28(3):408–18. doi:10.1021/tx5003723.

    Article  CAS  PubMed  Google Scholar 

  53. Westermann B. Bioenergetic role of mitochondrial fusion and fission. Biochim Biophys Acta. 2012;1817(10):1833–8. doi:10.1016/j.bbabio.2012.02.033.

    Article  CAS  PubMed  Google Scholar 

  54. Wittkopp S, Staimer N, Tjoa T, Gillen D, Daher N, Shafer M, et al. Mitochondrial genetic background modifies the relationship between traffic-related air pollution exposure and systemic biomarkers of inflammation. PLoS One. 2013;8(5):e64444. doi:10.1371/journal.pone.0064444.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  55. •• Grevendonk L, Janssen BG, Vanpoucke C, Lefebvre W, Hoxha M, Bollati V, Nawrot TS. Mitochondrial oxidative DNA damage and exposure to particulate air pollution in mother-newborn pairs. Environ Health. 2016;15:10. doi:10.1186/s12940-016-0095-2. Early life PM exposure is associated strongly with systemic oxidative stress and can be assessed via increased mitochondrial oxidative DNA damage during pregnancy in both mothers and their newborns

    Article  PubMed  PubMed Central  Google Scholar 

  56. Valavanidis A, Vlachogianni T, Fiotakis C. 8-hydroxy-2′-deoxyguanosine (8-OHdG): a critical biomarker of oxidative stress and carcinogenesis. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2009;27(2):120–39. doi:10.1080/10590500902885684.

    Article  CAS  PubMed  Google Scholar 

  57. •• Wang XB, Gao HY, Hou BL, Huang J, Xi RG, Wu LJ. Nanoparticle realgar powders induce apoptosis in U937 cells through caspase MAPK and mitochondrial pathways. Arch Pharm Res. 2007;30(5):653–8. A study on the interaction between nanoparticle caspase, mitochondria and MAPK signal pathways to trigger apoptosis, model for PM 2.5 interaction postulated to be similar

    Article  CAS  PubMed  Google Scholar 

  58. Gosens I, Post JA, de la Fonteyne LJ, Jansen EH, Geus JW, Cassee FR, de Jong WH. Impact of agglomeration state of nano- and submicron sized gold particles on pulmonary inflammation. Part Fibre Toxicol. 2010;7(1):37. doi:10.1186/1743-8977-7-37.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  59. Kamdar O, Le W, Zhang J, Ghio AJ, Rosen GD, Upadhyay D. Air pollution induces enhanced mitochondrial oxidative stress in cystic fibrosis airway epithelium. FEBS Lett. 2008;582(25–26):3601–6. doi:10.1016/j.febslet.2008.09.030.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  60. Yang CF, Shen HM, Shen Y, Zhuang ZX, Ong CN. Cadmium-induced oxidative cellular damage in human fetal lung fibroblasts (MRC-5 cells). Environ Health Perspect. 1997;105(7):712–6.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  61. Almeida AM, Bertoncini CR, Borecky J, Souza-Pinto NC, Vercesi AE. Mitochondrial DNA damage associated with lipid peroxidation of the mitochondrial membrane induced by Fe2+-citrate. An Acad Bras Cienc. 2006;78(3):505–14.

    Article  CAS  PubMed  Google Scholar 

  62. Cejas P, Casado E, Belda-Iniesta C, De Castro J, Espinosa E, Redondo A, et al. Implications of oxidative stress and cell membrane lipid peroxidation in human cancer (Spain). Cancer Causes Control. 2004;15(7):707–19. doi:10.1023/B:CACO.0000036189.61607.52.

    Article  PubMed  Google Scholar 

  63. Madrigal JL, Olivenza R, Moro MA, Lizasoain I, Lorenzo P, Rodrigo J, Leza JC. Glutathione depletion, lipid peroxidation and mitochondrial dysfunction are induced by chronic stress in rat brain. Neuropsychopharmacology. 2001;24(4):420–9. doi:10.1016/S0893-133X(00)00208-6.

    Article  CAS  PubMed  Google Scholar 

  64. Muller L. Consequences of cadmium toxicity in rat hepatocytes: mitochondrial dysfunction and lipid peroxidation. Toxicology. 1986;40(3):285–95.

    Article  CAS  PubMed  Google Scholar 

  65. Lippai MLP. The role of the selective adaptor p62 and ubiquitin-like proteins in autophagy. Biomed Res Int. 2014;2014:11. doi:10.1155/2014/832704.

    Article  Google Scholar 

  66. Taylor EB, Rutter J. Mitochondrial quality control by the ubiquitin-proteasome system. Biochem Soc Trans. 2011;39(5):1509–13. doi:10.1042/BST0391509.

    Article  CAS  PubMed  Google Scholar 

  67. Kipen HM, Gandhi S, Rich DQ, Ohman-Strickland P, Laumbach R, Fan ZH, et al. Acute decreases in proteasome pathway activity after inhalation of fresh diesel exhaust or secondary organic aerosol. Environ Health Perspect. 2011;119(5):658–63. doi:10.1289/ehp.1002784.

    Article  CAS  PubMed  Google Scholar 

  68. Ruan LZC, Jin E, Kucharavy A, Zhang Y, Wen Z, Florens L, Li R. Cytosolic proteostasis through importing of misfolded proteins into mitochondria. Nature. 2017; doi:10.1038/nature21695.

    PubMed  Google Scholar 

  69. Merkwirth C, Jovaisaite V, Durieux J, Matilainen O, Jordan SD, Quiros PM, et al. Two conserved histone demethylases regulate mitochondrial stress-induced longevity. Cell. 2016;165(5):1209–23. doi:10.1016/j.cell.2016.04.012.

    Article  CAS  PubMed  Google Scholar 

  70. Tian Y, Garcia G, Bian Q, Steffen KK, Joe L, Wolff S, et al. Mitochondrial stress induces chromatin reorganization to promote longevity and UPR(mt). Cell. 2016;165(5):1197–208. doi:10.1016/j.cell.2016.04.011.

    Article  CAS  PubMed  Google Scholar 

  71. Coulter JB, O'Driscoll CM, Bressler JP. Hydroquinone increases 5-hydroxymethylcytosine formation through ten eleven translocation 1 (TET1) 5-methylcytosine dioxygenase. J Biol Chem. 2013;288(40):28792–800. doi:10.1074/jbc.M113.491365.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  72. Agrawal A, Prakash YS. Obesity, metabolic syndrome, and airway disease: a bioenergetic problem? Immunol Allergy Clin N Am. 2014;34(4):785–96. doi:10.1016/j.iac.2014.07.004.

    Article  Google Scholar 

  73. Gomez-Cabrera MC, Domenech E, Romagnoli M, Arduini A, Borras C, Pallardo FV, et al. Oral administration of vitamin C decreases muscle mitochondrial biogenesis and hampers training-induced adaptations in endurance performance. Am J Clin Nutr. 2008;87(1):142–9.

    CAS  PubMed  Google Scholar 

  74. Gvozdjakova A, Kucharska J, Bartkovjakova M, Gazdikova K, Gazdik FE. Coenzyme Q10 supplementation reduces corticosteroids dosage in patients with bronchial asthma. Biofactors. 2005;25(1–4):235–40.

    Article  CAS  PubMed  Google Scholar 

  75. Jun AS, Trounce IA, Brown MD, Shoffner JM, Wallace DC. Use of transmitochondrial cybrids to assign a complex I defect to the mitochondrial DNA-encoded NADH dehydrogenase subunit 6 gene mutation at nucleotide pair 14459 that causes Leber hereditary optic neuropathy and dystonia. Mol Cell Biol. 1996;16(3):771–7.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  76. •• Bacman SR, Williams SL, Garcia S, Moraes CT. Organ-specific shifts in mtDNA heteroplasmy following systemic delivery of a mitochondria-targeted restriction endonuclease. Gene Ther. 2010;17(6):713–20. doi:10.1038/gt.2010.25. In vivo study on manipulation of mitochondrial heteroplasmy through recombinant technology

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  77. Bayona-Bafaluy MP, Blits B, Battersby BJ, Shoubridge EA, Moraes CT. Rapid directional shift of mitochondrial DNA heteroplasmy in animal tissues by a mitochondrially targeted restriction endonuclease. Proc Natl Acad Sci U S A. 2005;102(40):14392–7. doi:10.1073/pnas.0502896102.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  78. Ahmad T, Aggarwal K, Pattnaik B, Mukherjee S, Sethi T, Tiwari BK, et al. Computational classification of mitochondrial shapes reflects stress and redox state. Cell Death Dis. 2013;4:e461. doi:10.1038/cddis.2012.213.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  79. • Berridge MV, Dong L, Neuzil J. Mitochondrial DNA in tumor initiation, progression, and metastasis: role of horizontal mtDNA transfer. Cancer Res. 2015;75(16):3203–8. doi:10.1158/0008-5472.CAN-15-0859. One of the early evidences for the physiological existence and importance of mitochondrial transfer between cells

    Article  CAS  PubMed  Google Scholar 

  80. Islam MN, Das SR, Emin MT, Wei M, Sun L, Westphalen K, et al. Mitochondrial transfer from bone-marrow-derived stromal cells to pulmonary alveoli protects against acute lung injury. Nat Med. 2012;18(5):759–65. doi:10.1038/nm.2736.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  81. Tan AS, Baty JW, Dong LF, Bezawork-Geleta A, Endaya B, Goodwin J, et al. Mitochondrial genome acquisition restores respiratory function and tumorigenic potential of cancer cells without mitochondrial DNA. Cell Metab. 2015;21(1):81–94. doi:10.1016/j.cmet.2014.12.003.

    Article  CAS  PubMed  Google Scholar 

  82. Onfelt B, Nedvetzki S, Yanagi K, Davis DM. Cutting edge: membrane nanotubes connect immune cells. J Immunol. 2004;173(3):1511–3.

    Article  PubMed  Google Scholar 

  83. Rustom A, Saffrich R, Markovic I, Walther P, Gerdes HH. Nanotubular highways for intercellular organelle transport. Science. 2004;303(5660):1007–10. doi:10.1126/science.1093133.

    Article  CAS  PubMed  Google Scholar 

  84. Abounit S, Zurzolo C. Wiring through tunneling nanotubes—from electrical signals to organelle transfer. J Cell Sci. 2012;125(Pt 5):1089–98. doi:10.1242/jcs.083279.

    Article  CAS  PubMed  Google Scholar 

  85. Gerdes HH, Carvalho RN. Intercellular transfer mediated by tunneling nanotubes. Curr Opin Cell Biol. 2008;20(4):470–5. doi:10.1016/j.ceb.2008.03.005.

    Article  CAS  PubMed  Google Scholar 

  86. •• Ahmad T, Mukherjee S, Pattnaik B, Kumar M, Singh S, Rehman R, et al. Miro1 regulates intercellular mitochondrial transport & enhances mesenchymal stem cell rescue efficacy. EMBO J. 2014;33(9):994–1010. doi:10.1002/embj.201386030. First report providing mechanistic understanding of mitochondrial transfer through tunneling nanotubules and the critical role of mitochondria in allergic asthma models

    CAS  PubMed  PubMed Central  Google Scholar 

  87. •• Agrawal A, Mabalirajan U. Rejuvenating cellular respiration for optimizing respiratory function: targeting mitochondria. Am J Physiol Lung Cell Mol Physiol. 2016;310(2):L103–13. doi:10.1152/ajplung.00320.2015. A perspective on the role of mitochondrial dysfunction in lung disease and a review of potential strategies to target mitochondria

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. CSIR Institute of Genomics and Integrative Biology, Delhi University campus, Mall Road, Delhi, 110007, India

    Divyaanka Iyer & Anurag Agrawal

  2. Indian Institute of Public Health, Gurugram, India

    Navya Mishra

  3. Chest Research Foundation, Pune, India

    Navya Mishra

  4. Academy of Scientific and Innovative Research, New Delhi, India

    Navya Mishra & Anurag Agrawal

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  2. Navya Mishra
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  3. Anurag Agrawal
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Correspondence to Anurag Agrawal.

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Drs. Iyer, Mishra, and Agrawal declare no conflicts of interest relevant to this manuscript.

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This article does not contain any studies with human or animal subjects performed by any of the authors.

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This article is part of the Topical Collection on Basic and Applied Science

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Iyer, D., Mishra, N. & Agrawal, A. Mitochondrial Function in Allergic Disease. Curr Allergy Asthma Rep 17, 29 (2017). https://doi.org/10.1007/s11882-017-0695-0

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