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MicroRNAs in Allergic Disease

  • Basic and Applied Science (I Lewkowich, Section Editor)
  • Published:
Current Allergy and Asthma Reports Aims and scope Submit manuscript

Abstract

Purpose of Review

MicroRNAs (miRNAs) are short, single-stranded, non-coding RNAs that are increasingly being recognized as important epigenetic regulators. They have been implicated in the pathogenesis of many diseases including cancer, cardiovascular diseases, connective tissue diseases, and neuromuscular disorders.

Recent Findings

A few miRNAs have already been recognized as a core set of miRNAs important in allergic inflammation. These include let-7, miR-21, miR-142, and miR-146.

Summary

This review aims to bring together some of the recent findings on how miRNAs regulate allergic inflammation with special focus on asthma, atopic dermatitis, allergic rhinitis, and eosinophilic esophagitis. We will also touch upon extracellular miRNAs and future perspective of this field of study.

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Authors and Affiliations

  1. Department of Pediatrics, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, Chiba, 260-8670, Japan

    Eishika Dissanayake

  2. Department of General Medical Science, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, Chiba, 260-8670, Japan

    Yuzaburo Inoue

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  1. Eishika Dissanayake
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Correspondence to Yuzaburo Inoue.

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Drs. Dissanayake and Inoue declare no conflicts of interest relevant to this manuscript.

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This article does not contain any studies with human or animal subjects performed by any of the authors.

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Dissanayake, E., Inoue, Y. MicroRNAs in Allergic Disease. Curr Allergy Asthma Rep 16, 67 (2016). https://doi.org/10.1007/s11882-016-0648-z

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