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IgG4-Related Ophthalmic Disease: Pooling of Published Cases and Literature Review

  • Autoimmunity (TK Tarrant, Section Editor)
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Abstract

In recent years, IgG4-related ophthalmic disease (IgG4-ROD) has emerged as a common cause of orbital inflammation, accounting for a substantial proportion of idiopathic orbital inflammation and lymphoid hyperplasia. The last pooled analysis of published cases was conducted in 2012, but a large number of new cases have been added to the literature since then. In this review, we present the demographic, clinical, histological, and treatment data for 172 published cases of biopsy-confirmed IgG4-ROD. Results are accompanied by a review of the relevant literature.

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Albert Wu, Nicholas H. Andrew, Alan A. McNab, and Dinesh Selva declare that they have no conflict of interest.

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This article does not contain any studies with human or animal subjects performed by any of the authors.

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    Authors and Affiliations

    1. South Australian Institute of Ophthalmology, University of Adelaide, Level 8, East Wing, Royal Adelaide Hospital, Adelaide, SA, 5000, Australia

      Albert Wu, Nicholas H Andrew & Dinesh Selva

    2. Centre for Eye Research Australia, University of Melbourne, Melbourne, Australia

      Alan A McNab

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    1. Albert Wu
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    2. Nicholas H Andrew
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    Correspondence to Albert Wu.

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    This article is part of the Topical Collection on Autoimmunity

    Albert Wu and Nicholas H Andrew contributed equally to this work.

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    Wu, A., Andrew, N.H., McNab, A.A. et al. IgG4-Related Ophthalmic Disease: Pooling of Published Cases and Literature Review. Curr Allergy Asthma Rep 15, 27 (2015). https://doi.org/10.1007/s11882-015-0530-4

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