Evaluation of Antibiotic Allergy: the Role of Skin Tests and Drug Challenges

  • Roland Solensky
  • David A. KhanEmail author
Part of the following topical collections:
  1. Topical Collection on Anaphylaxis and Drug Allergy


Antibiotic allergies are frequently reported in both adult and pediatric populations. While a detailed drug history is essential in the evaluation of antibiotic allergy, the history is typically insufficient to determine the presence of a drug allergy. The most readily available diagnostic testing for evaluating antibiotic allergies are drug skin testing and drug challenges. This review will focus on updates in the evaluation of antibiotic allergy utilizing immediate skin tests, delayed intradermal testing, drug patch tests, and drug challenges for both adults and children with histories of antibiotic allergies.


Antibiotic allergy Penicillin allergy Drug challenge Drug patch tests Drug skin tests Pediatric 


Compliance with Ethics Guidelines

Conflict of Interest

Roland Solensky declares that he does consulting for Optimer Pharmaceuticals and that he and his institution have received grant money from Allerquest and Merck. David A. Khan declares no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by the authors.


Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  1. 1.The Corvallis ClinicCorvallisUSA
  2. 2.Division of Allergy and Immunology, Department of Internal MedicineUniversity of Texas Southwestern Medical CenterDallasUSA

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