Current Allergy and Asthma Reports

, Volume 13, Issue 5, pp 518–527 | Cite as

Systemic Contact Dermatitis and Allergy to Biomedical Devices

  • Marcella AquinoEmail author
  • Tania Mucci


Systemic contact dermatitis (SCD) refers to a skin condition where an individual who is cutaneously sensitized to an allergen will subsequently react to that same allergen or a cross-reacting allergen via the systemic route. It occurs to allergens including metals, medications, and foods. There has been recent interest in metal allergy as it relates to the implantation of devices such as orthopedic, dental, cardiac, and gynecologic implants. This review will briefly address all causes of systemic contact dermatitis with a special and expanded focus on metal implant allergy. We present literature on SCD to various metal biomedical devices, patch testing for diagnosis of metal allergy pre and post implantation and treatment.


Systemic contact dermatitis Allergic contact dermatitis Metal allergy Orthopedic implant Dental implant Dental amalgam Stent Pacemaker Intrauterine devices Biomedical devices 


Compliance with Ethics Guidelines

Conflict of Interest

Marcella Aquino has been treasurer and a board member of the Long Island Allergy & Asthma Society; has served as principal investigator on a clinical trial for Merck & Co.-SPIRO; has served as a sub-investigator on clinical trials for Novartis, Genentech, Baxter, and Dyax. Corp.; has been paid for giving lectures by the ACAAI; has had travel expenses covered/reimbursed for travel to meetings by the ACAAI; and has had travel expenses covered/reimbursed for travel to investigators’ meetings by Merck & Co.

Tania Mucci declares that she has no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.


Papers of particular interest, published recently, have been hihglighted as: • Of importance •• Of major importance

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Section of Allergy and Clinical ImmunologyWinthrop-University HospitalMineolaUSA
  2. 2.Rheumatology, Allergy & ImmunologyWinthrop University HospitalMineolaUSA

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