Current Allergy and Asthma Reports

, Volume 13, Issue 4, pp 389–398

Accelerated Immunotherapy Schedules


DOI: 10.1007/s11882-013-0356-x

Cite this article as:
Calabria, C.W. Curr Allergy Asthma Rep (2013) 13: 389. doi:10.1007/s11882-013-0356-x


Rush and cluster immunotherapy schedules are accelerated immunotherapy build-up schedules. A cluster immunotherapy schedule involves the patient receiving several allergen injections (generally 2–4) sequentially in a single day of treatment on nonconsecutive days. The maintenance dose is generally reached in 4–8 weeks. In rush immunotherapy protocols, higher doses are administered at 15- to 60-min intervals over a 1- to 3-day period until the maintenance dose is achieved. This review will serve as an update for accelerated immunotherapy schedules. The review will include recent investigations demonstrating the safety of cluster schedules in atopic dermatitis, pediatric patients, and inhalant allergen mixtures and an accelerated protocol utilizing an infusion pump for allergen delivery. There has also been further elucidation on the immunological changes which occur during accelerated immunotherapy. Finally, new studies analyzing systemic reaction risk factors are discussed.


Accelerated immunotherapy schedules Cluster immunotherapy Rush immunotherapy Subcutaneous immunotherapy Pre-medication Systemic reactions Large local reactions 

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Dilley Allergy and Asthma Specialists LLPSan AntonioUSA

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