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House Dust Mite Interactions with Airway Epithelium: Role in Allergic Airway Inflammation

  • ALLERGENS (RK BUSH, SECTION EDITOR)
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Abstract

House dust mite (HDM) allergens are the most prevalent allergens associated with asthma and rhinitis around the world. The mechanisms of allergic sensitization and allergic airway inflammation after exposure to HDM have been studied extensively, but many questions remain unanswered. Airway epithelial cells are the first line of defense against external antigens and are considered an important player in the development of allergic airway inflammation. Both genetic susceptibility to allergic sensitization and HDM composition play decisive roles in the outcome of HDM-epithelium interactions, especially regarding airway epithelial dysfunction and allergic inflammation. Interactions between HDM and the airway epithelium have consequences for both development of allergy and asthma and development of allergic airway inflammation. This review will describe in detail these interactions and will identify issues that require more study.

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Conflict of Interest

Vivek D. Gandhi declares that he has no conflict of interest.

Courtney Davidson declares that she has no conflict of interest.

Muhammad Asaduzzaman declares that he has no conflict of interest.

Drew Nahirney declares that he has no conflict of interest.

Harissios Vliagoftis has received grant support from the CIHR, National Sanitarium Association, Ironwood, Merck & Co., and AstraZeneca, and has received honoraria from Pfizer.

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Authors and Affiliations

  1. Pulmonary Research Group, Department of Medicine, University of Alberta, 567 HMRC, Edmonton, AB T6G 2S2, Canada

    Vivek D. Gandhi, Muhammad Asaduzzaman & Drew Nahirney

  2. Pulmonary Research Group, Department of Medicine, University of Alberta, 559 HMRC, Edmonton, AB T6G 2S2, Canada

    Courtney Davidson

  3. Pulmonary Research Group, Department of Medicine, University of Alberta, 550A HMRC, Edmonton, AB T6G 2S2, Canada

    Harissios Vliagoftis

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  1. Vivek D. Gandhi
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  2. Courtney Davidson
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  3. Muhammad Asaduzzaman
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  4. Drew Nahirney
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  5. Harissios Vliagoftis
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Correspondence to Harissios Vliagoftis.

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Gandhi, V.D., Davidson, C., Asaduzzaman, M. et al. House Dust Mite Interactions with Airway Epithelium: Role in Allergic Airway Inflammation. Curr Allergy Asthma Rep 13, 262–270 (2013). https://doi.org/10.1007/s11882-013-0349-9

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  • DOI: https://doi.org/10.1007/s11882-013-0349-9

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