Current Allergy and Asthma Reports

, Volume 12, Issue 4, pp 339–345 | Cite as

Sesame Seed Food Allergy

FOOD ALLERGY (D ATKINS, SECTION EDITOR)

Abstract

The number of reports regarding sesame seed food allergy (SFA) has increased significantly worldwide over the past two decades, either due to a genuine increase in SFA or merely an increase in its awareness. Its prevalence is difficult to estimate due to the lack of well designed prospective population-based studies. Based on the available data, we estimate that SFA affects 0.1–0.2 % of the population, in areas where the food is available. Albeit this prevalence appears to be relatively low, it is approximately one-half of that of persistent cow’s milk allergy. While only one fatality has been reported, the significant number of SFA patients presenting as anaphylaxis indicates the potential risk. Many reports based the diagnosis of SFA on sensitization criteria alone, particularly amongst atopic dermatitis patients. Elimination of sesame from the diet of these children utilizing such criteria is not justified, and may even increase the risk for developing SFA.

Keywords

Food allergy Sesame seed SPT Specific IgE Oral Challenge Anaphylaxis 

Abbreviations

AD

Atopic dermatitis

DBPCFC

Double blind placebo controlled food challenge

IgE

Immunoglobulin E

OC

Oral challenge

SFA

Sesame-seed food allergy

sIgE

Specific immunoglobulin E

SPT

Skin prick test

References

  1. 1.
    Prescott S, Allen KJ. Food allergy: Riding the second wave of the allergy epidemic. Pediatr Allergy Immunol. 2011;22:155–60.PubMedCrossRefGoogle Scholar
  2. 2.
    Sampson HA. Update on food allergy. J Allergy Clin Immunol. 2004;113:805–19.PubMedCrossRefGoogle Scholar
  3. 3.
    Lack G. Food allergy. N Engl J Med. 2008;359:1252–60.PubMedCrossRefGoogle Scholar
  4. 4.
    Sicherer SH, Sampson HA. Food allergy. J Allergy Clin Immunol. 2010;125:S116–25.PubMedCrossRefGoogle Scholar
  5. 5.
    Lack G. Update on risk factors for food allergy. J Allergy Clinical Immunol. 2012;129:1187–97.Google Scholar
  6. 6.
    Novembre E, Cianferoni A, Bernardini R, et al. Anaphylaxis in children: clinical and allergologic features. Pediatrics. 1998;101:1–8.CrossRefGoogle Scholar
  7. 7.
    Goh DLM, Lau YN, Chew FT, et al. Pattern of food-induced anaphylaxis in children of an Asian community. Allergy. 1999;54:78–92.CrossRefGoogle Scholar
  8. 8.
    Gangur V, Kelly C, Navuluri L. Sesame allergy: a growing allergy of global proportions? Ann Allergy Asthma Immunol. 2005;95:4–11.PubMedCrossRefGoogle Scholar
  9. 9.
    Dalal I, Binson I, Reifen R, et al. Food allergy is a matter of geography after all: sesame as a major cause of severe IgE-mediated food allergic reactions among infants and young children in Israel. Allergy. 2002;57:362–5.PubMedCrossRefGoogle Scholar
  10. 10.
    Cohen A, Goldberg M, Levy B, et al. Sesame food allergy and sensitization: the natural history and long-term follow-up. Pediatr Allergy Immunol. 2007;18:217–23.PubMedCrossRefGoogle Scholar
  11. 11.
    Aaronov D, Tasher D, Levine A, et al. Natural history of food allergy in infants and children in Israel. Ann Allergy Asthma Immunol. 2008;101:637–40.PubMedCrossRefGoogle Scholar
  12. 12.
    Rubenstein L. Sensitivity to sesame seed and sesame oil. NY State J Med. 1950;50:343–4.Google Scholar
  13. 13.
    Torsney PJ. Hypersensitivity to sesame seed. J Allergy. 1964;35:514–9.PubMedCrossRefGoogle Scholar
  14. 14.
    Kagi MK, Wuthrich B. Falafel burger anaphylaxis due to sesame seed allergy. Ann Allergy. 1993;71:127–9.PubMedGoogle Scholar
  15. 15.
    Keskinen H, Ostman P, Veheri E, et al. A case of occupational asthma, rhinitis and urticaria due to sesame allergy. Clin Exp Allergy. 1991;21:623–4.PubMedCrossRefGoogle Scholar
  16. 16.
    Derby CJ, Gowland MH, Hourihane JO. Sesame allergy in Britain: a questionnaire survey of members of the Anaphylaxis Campaign. Pediatr Allergy Immunol. 2005;16:171–5.PubMedCrossRefGoogle Scholar
  17. 17.
    Osterballe M, Hansen TK, Mortz CG, et al. The prevalence of food hypersensitivity in an unselected population of children and adults. Pediatr Allergy immunol. 2005;16:567–73.PubMedCrossRefGoogle Scholar
  18. 18.
    Venter C, Pereira B, Grundy J, et al. Prevalence of sensitization reported and objectively assessed food hypersensitivity amongst six-year-old children: a population-based study. Pediatr Allergy Immunol. 2006;17:356–63.PubMedCrossRefGoogle Scholar
  19. 19.
    Amin AJ, Davis CM. Changes in prevalence and characteristics of IgE-mediated food allergies in children refered to a tertiary care center in 2003–2008. Allergy Asthma Proc. 2012;33:95–101.PubMedCrossRefGoogle Scholar
  20. 20.
    Ben-Shoshan M, Harington DW, Soller L, et al. A population-based study on peanut, tree nut, fish, shellfish, and sesame allergy prevalence in Canada. J Allergy Clin Immunol. 2010;125:1327–35.PubMedCrossRefGoogle Scholar
  21. 21.
    Sicherer SH, Munoz-Furlong A, Godbold JH, Sampson HA. US prevalence of self-reported peanut, tree nut, and sesame allergy: 11-year follow-up. J Allergy Clin Immunol. 2010;125:1322–6.PubMedCrossRefGoogle Scholar
  22. 22.
    Osborne NJ, Koplin JJ, Martin PE, et al. Prevalence of challenge-proven IgE-mediated food allergy using population-based sampling and predetermined challenge criteria in infants. J Allergy Clin Immunol. 2011;127:668–76.PubMedCrossRefGoogle Scholar
  23. 23.
    Ben Shoshan M, Knoll M, Soller L, et al. Prevalence of common food allergies in Canada: Targeting specific demographic groups across Canada. J Allergy Clin Immunol. 2012;129:AB235.CrossRefGoogle Scholar
  24. 24.
    Pajno GB, Passalacqua G, Magazzu G, et al. Anaphylaxis to sesame. Allergy 2000;199–201.Google Scholar
  25. 25.
    Vetander M, Helander D, Flodstrom C, et al. Anaphylaxis and reactions to foods in children—a population-based case study of emergency department visits. Clin Exp Allergy. 2012;42:568–77.PubMedCrossRefGoogle Scholar
  26. 26.
    Mallish D, Glovsky MM, Hoffman DR, et al. Anaphylaxis after sesame seed ingestion. J Allergy Clin Immunol. 1981;67:35–8.CrossRefGoogle Scholar
  27. 27.
    Calvani M, Cardinale F, Martelli A, et al. Risk factors for severe pediatric food anaphylaxis in Italy. Pediatr Allergy Immunol. 2011;22:813–9.PubMedCrossRefGoogle Scholar
  28. 28.
    Irani C, Maalouly G, Mirna G, Hassan K. Food allergy in Lebanon: Is sesame seed the "Middle Eastern" peanut. World Allergy Organization Journal. 2011;4:1–3.CrossRefGoogle Scholar
  29. 29.
    Al-Hammadi S, Zoubeidi T, Al-Maskari F. Predictors of childhood food allergy: significance and implications. Asian Pac J Allergy Immunol. 2011;29:313–7.PubMedGoogle Scholar
  30. 30.
    Barzegar S, Akramian R, Zahra P, et al. Common causes of anaphylaxis in children: the first report of anaphylaxis registry in Iran. World Allergy Organization Journal. 2010;3(1):9–13.CrossRefGoogle Scholar
  31. 31.
    Sicherer SH. Epidemiology of food allergy. J Allergy Clin Immunol. 2011;127:594–602.PubMedCrossRefGoogle Scholar
  32. 32.
    Du Toit G, Katz Y, Sasieni P, et al. Early consumption of peanuts in infancy is associated with a low prevalence of peanut allergy. J Allergy Clin Immunol. 2008;122:984–91.PubMedCrossRefGoogle Scholar
  33. 33.
    Levy Y, Danon YL. Allergy to sesame seed in infants. Allergy. 2001;56:193–4.PubMedCrossRefGoogle Scholar
  34. 34.
    Dalal I, Binson I, Levine A, et al. The pattern of sesame sensitivity among infants and children. Pediatr Allergy Immunol. 2003;14:312–6.PubMedCrossRefGoogle Scholar
  35. 35.
    Pongracic JA, Bock SA, Sicherer SH. Oral food challenge practices among allergist in the United States. J Allergy Clinical Immunol. 2012;129:565–5.CrossRefGoogle Scholar
  36. 36.
    Canani RB, Nocerino R, Terrin G, et al. Food allergy diagnostic practice in Italian children. J Allergy Clinical Immunol. 2012;129:1423–4.Google Scholar
  37. 37.
    Sporik R, Hill D. Allergy to peanut, nuts and sesame seed in Australian children (Letter). BMJ. 1996;313:1477–8.PubMedCrossRefGoogle Scholar
  38. 38.
    Takeishi D, Komata T, Utsunomiya T, et al. Oral challenge test for sesame in Japan, a summary of 91 cases. Allergy 211;66(supp):236.Google Scholar
  39. 39.
    Rance F, Kanny G, Dutau G, Moneret-Vautrin DA. Food hypersensitivity in children: Clinical aspects and distribution of allergens. Pediatr Allergy Immunol. 1999;10:33–8.PubMedCrossRefGoogle Scholar
  40. 40.
    Fleischer DM, Bock SA, Spears GC, et al. Oral food challenges in children with a diagnosis of food allergy. J Pediatrics. 2011;158:578–83.CrossRefGoogle Scholar
  41. 41.
    Zavalkoff S, Kagan R, Joseph L, et al. The value of sesame-specific IgE levels in predicting sesame allergy. J Allergy Clin Immunol. 2008;121:1508–10.PubMedCrossRefGoogle Scholar
  42. 42.
    Permaul P, Stutius LM, Sheehan WJ, et al. Sesame allergy: role of specific IgE and skin prick testing in predicting food challenge results. Allergy Asthma Proc. 2009;30:643–8.PubMedCrossRefGoogle Scholar
  43. 43.
    Kanny G, De Hauteclocque C, Moneret-Vautrin DA. Sesame seed and sesame seed oil contain masked allergens of growing importance. Allergy. 1996;51:952–7.PubMedGoogle Scholar
  44. 44.
    Larramendi CH, Martín Esteban M, Pascual Marcos C, et al. Possible consequences of elimination diets in asymptomatic immediate hypersensitivity to fish. Allergy. 1992;47:490–4.PubMedCrossRefGoogle Scholar
  45. 45.
    Flinterman AE, Knulst AC, Meijer Y, et al. Acute allergic reactions in children with AEDS after prolonged cow’s milk elimination diets. Allergy. 2006;61:370–4.PubMedCrossRefGoogle Scholar
  46. 46.
    Pumphrey RS, Gowland MH. Further fatal allergic reactions to food in the United Kingdom, 1999–2006. J Allergy Clin Immunol. 2007;119:1018–9.PubMedCrossRefGoogle Scholar
  47. 47.
    Kubo Y, Nonaka S, Yoshida H. Contact sensitivity to unsaponifiable substances in sesame oil. Contact Dermatitis. 1986;15:215–7.PubMedCrossRefGoogle Scholar
  48. 48.
    Caimmi S, Marseglia A, Ciammi D, Marseglia GL. Friday asthma crisis in the daughter of two bakers. Int J Immunopathol Pharmacol. 2011;24:517–8.PubMedGoogle Scholar
  49. 49.
    Bock SA, Munoz-Furlong A, Sampson HA. Further fatalities caused by anaphylactic reactions to food, 2001–2006. J Allergy Clin Immunol. 2007;119:1016–8.PubMedCrossRefGoogle Scholar
  50. 50.
    Hourihane JO’B, Roberts SA, Warner JO. Resolution of peanut allergy: case control study. BMJ. 1998;316:1271–5.PubMedCrossRefGoogle Scholar
  51. 51.
    Beyer K, Morrow E, Li XM, et al. Effects of cooking methods on peanut allergenicity. J Allergy Clin Immunol. 2001;107:1077–81.PubMedCrossRefGoogle Scholar
  52. 52.
    Pastorello EA, Varin E, Farioli L, et al. The major allergen of sesame seeds (Sesamum indicum) is a 2 S albumin. J Chromatogr B: Biomed Sci Appl. 2001;756:85–93.CrossRefGoogle Scholar
  53. 53.
    Wolff N, Cogan U, Admon A, et al. Allergy to sesame in humans is associated primarily with IgE antibody to a 14 kDa 2 S albumin precursor. Food Chem Toxicol. 2003;41:1165–74.PubMedCrossRefGoogle Scholar
  54. 54.
    Wolff N, Yannai S, Karin Y, et al. Identification and characterization of linear B-cell epitopes of beta-blobulin, a major allergen of sesame seeds. J Allergy Clin Immunol. 2004;114:1151–8.PubMedCrossRefGoogle Scholar
  55. 55.
    Leduc V, Moneret-Vautrin DA, Tzen JTC, et al. Identification of oleosins as major allergens in sesame seed allergic patients. Allergy. 2006;61:349–56.PubMedCrossRefGoogle Scholar
  56. 56.
    Beyer K, Grishina G, Bardina L, Sampson HA. Identification of 2 new sesame seed allergens: Ses i 6 and Ses i 7. J Allergy Clin Immunol. 2007;119:1554–6.PubMedCrossRefGoogle Scholar
  57. 57.
    Magni C, Ballabio C, Restani P, et al. Molecular insight into IgE-mediated reactions to sesame (Sesamum indicum L.) seed proteins. Ann Allergy Asthma Immunol. 2010;105:458–64.PubMedCrossRefGoogle Scholar
  58. 58.
    Vocks E, Borga A, Szliska C, et al. Common allergenic structures in hazelnut, rye grain, sesame seeds, kiwi, and poppy seeds. Allergy. 1993;48:168–72.PubMedCrossRefGoogle Scholar
  59. 59.
    Stutius LM, Sheehan WJ, Rangsithienchai P, et al. Characterizing the relationship between sesame, coconut, and nut allergy in children. Pediatr Allergy Immunol. 2010;21:1114–8.PubMedCrossRefGoogle Scholar
  60. 60.
    Katz Y, Rajuan N, Goldberg MR, et al. Early exposure to cow’s milk protein is protective against IgE-mediated cow’s milk protein allergy. J Allergy Clin Immunol. 2010;126(1):77–82.e1.PubMedCrossRefGoogle Scholar
  61. 61.
    Longo G, Barbi E, Berti I, et al. Specific oral tolerance induction in children with very severe cow’s milk-induced reactions. J Allergy Clin Immunol. 2008;121(2):343–7.PubMedCrossRefGoogle Scholar
  62. 62.
    Skripak JM, Nash SD, Rowley H, Brereton NH, Oh S, Hamilton RG, Matsui EC, Burks AW, Wood RA. A randomized, double-blind, placebo-controlled study of milk oral immunotherapy for cow’s milk allergy. J Allergy Clin Immunol. 2008;122(6):1154–60.PubMedCrossRefGoogle Scholar
  63. 63.
    Vickery BP. Egg oral immunotherapy. Curr Opin Allergy Clin Immunol. 2012;12:278–82.Google Scholar
  64. 64.
    Blumchen K, Ulbricht H, Staden U, et al. Oral peanut immunotherapy in children with peanut anaphylaxis. J Allergy Clin Immunol. 2010;126:83–91.PubMedCrossRefGoogle Scholar
  65. 65.
    Jones SM, Pons L, Roberts JL, et al. Clinical efficacy and immune regulation with peanut oral immunotherapy. J Allergy Clin Immunol. 2009;124:292–300.PubMedCrossRefGoogle Scholar
  66. 66.
    Varshney P, Jones SM, Scurlock AM, et al. A randomized controlled study of peanut oral immunotherapy: clinical desensitization and modulation of the allergic response. J Allergy Clin Immunol. 2011;127:654–60.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  1. 1.Pediatric Allergy/Immunology Unit, E. Wolfson Medical Center, Sackler School of MedicineTel-Aviv UniversityHolonIsrael
  2. 2.The Institute of Allergy, Pulmonary and ImmunologyAssaf Harofeh Medical CenterZerifinIsrael

Personalised recommendations