Current Allergy and Asthma Reports

, Volume 12, Issue 4, pp 332–338 | Cite as

Chinese Herbal Therapy for the Treatment of Food Allergy

FOOD ALLERGY (D ATKINS, SECTION EDITOR)

Abstract

Traditional Chinese medicine (TCM) has been widely used in China to treat various diseases for thousands of years. Given its reputed effectiveness, low cost, and favorable safety profile, TCM is attracting great interest in Western societies as a source of therapy for an array of illnesses, including allergies and asthma. Although food allergy has not been described in the TCM literature, a novel treatment for food allergy, named the food allergy herbal formula-2 (FAHF-2), was developed using TCM principles. Using a well-characterized murine model of peanut allergy, FAHF-2 has been shown to be highly effective in providing long-term protection against peanut-induced anaphylaxis, with a high safety margin. Phase 1 human trials have demonstrated the safety of FAHF-2 in food allergic individuals. Currently, a phase 2 trial examining efficacy of FAHF-2 is on-going. Other TCMs also show a potential for treating food allergies in preclinical studies.

Keywords

Food Allergy Treatment Chinese herbal medicine Therapy FAHF-2 Food allergy herbal formula-2 

Notes

Acknowledgments

Julie Wang, MD is funded in part by a grant from the National Institutes of Health/National Institute of Allergy and Infectious Diseases (K23 AI083883).

Xiu-Min Li, MD is funded in part by grants from the National Institutes of Health/National Center for Complementary and Alternative Medicine (1R01AT001495-01A1 and 2R01AT001495-05A1), Food Allergy Initiative, and the Winston Wolkoff Integrative Medicine for Allergy and Immunology Foundation.

Disclosure

No potential conflicts of interest relevant to this article were reported.

References

Papers of particular interest, published recently, have been highlighted as: •  Of importance •• Of major importance

  1. 1.
    • Gupta RS, Springston EE, Warrier MR, et al. The prevalence, severity, and distribution of childhood food allergy in the United States. Pediatrics. 2011;128:e9–17. This study shows that food allergy is estimated to affect 8% of U.S. children, with over 1/3 having a history of severe reactions.PubMedCrossRefGoogle Scholar
  2. 2.
    •• Boyce JA, Assa'ad A, Burks AW, et al. Guidelines for the diagnosis and management of food allergy in the United States: summary of the NIAID-sponsored expert panel report. J Allergy Clin Immunol. 2010;126:1105–18. These guidelines provide recommendations for the diagnosis and management of food allergy, as well as identify gaps in knowledge to inform future research.PubMedCrossRefGoogle Scholar
  3. 3.
    Barnes PM, Bloom B, Nahin RL. Complementary and alternative medicine use among adults and children: United States, 2007. Natl Health Stat Report. 2008;12:1–23.PubMedGoogle Scholar
  4. 4.
    Hsu CH, Lu CM, Chang TT. Efficacy and safety of modified Mai-Men-Dong-Tang for treatment of allergic asthma. Pediatr Allergy Immunol. 2005;16:76–81.PubMedCrossRefGoogle Scholar
  5. 5.
    Chan CK, Kuo ML, Shen JJ, et al. Ding Chuan Tang, a Chinese herb decoction, could improve airway hyper-responsiveness in stabilized asthmatic children: a randomized, double-blind clinical trial. Pediatr Allergy Immunol. 2006;17:316–22.PubMedCrossRefGoogle Scholar
  6. 6.
    Chang TT, Huang CC, Hsu CH. Clinical evaluation of the Chinese herbal medicine formula STA-1 in the treatment of allergic asthma. Phytother Res. 2006;20:342–7.PubMedCrossRefGoogle Scholar
  7. 7.
    Wen MC, Wei CH, Hu ZQ, et al. Efficacy and tolerability of anti-asthma herbal medicine intervention in adult patients with moderate-severe allergic asthma. J Allergy Clin Immunol. 2005;116:517–24.PubMedCrossRefGoogle Scholar
  8. 8.
    Kelly-Pieper K, Patil SP, Busse P, et al. Safety and tolerability of an antiasthma herbal Formula (ASHMI) in adult subjects with asthma: a randomized, double-blinded, placebo-controlled, dose-escalation phase I study. J Altern Complement Med. 2009;15:735–43.PubMedCrossRefGoogle Scholar
  9. 9.
    Bensky D, Gamble A. Chinese herbal medicine. In: Materia medica. Revised ed. Seattle: Eastland Press; 1993.Google Scholar
  10. 10.
    Huang KC. The pharmacology of Chinese herbs. 2nd ed. Boca Raton: CRC Press; 1999. p. 118–20.Google Scholar
  11. 11.
    Tasaka K, Akagi M, Miyoshi K, et al. Anti-allergic constituents in the culture medium of Ganoderma lucidum. (I). Inhibitory effect of oleic acid on histamine release. Agents Actions. 1988;23:153–6.PubMedCrossRefGoogle Scholar
  12. 12.
    He FH, Wu WP. Clinical application of Wu-Mei-Wan. Zhong Gui Yi Yao Xue Ba. 2004;19:748–50.Google Scholar
  13. 13.
    Hu KM, He YM. Correlation between complex prescription with lucidum ganoderma in treating rhinoallergitus and constitution. Shanghai J Trad Chinese Med. 2000;8:39–41.Google Scholar
  14. 14.
    Wen MC, Teper A, Srivistava KD, et al. Immunology of T cells by the Chinese herbal medicine Ling Zhi (gandoderma lucidum). J Allergy Clin Immunol. 2003;111:S320.CrossRefGoogle Scholar
  15. 15.
    Srivastava KD, Kattan JD, Zou ZM, et al. The Chinese herbal medicine formula FAHF-2 completely blocks anaphylactic reactions in a murine model of peanut allergy. J Allergy Clin Immunol. 2005;115:171–8.PubMedCrossRefGoogle Scholar
  16. 16.
    Qu C, Srivastava K, Ko J, et al. Induction of tolerance after establishment of peanut allergy by the food allergy herbal formula-2 is associated with up-regulation of interferon-gamma. Clin Exp Allergy. 2007;37:846–55.PubMedCrossRefGoogle Scholar
  17. 17.
    Srivastava KD, Qu C, Zhang T, et al. Food allergy herbal formula-2 silences peanut-induced anaphylaxis for a prolonged posttreatment period via IFN-gamma-producing CD8+ T cells. J Allergy Clin Immunol. 2009;123:443–51.PubMedCrossRefGoogle Scholar
  18. 18.
    Song Y, Qu C, Srivastava K, et al. Food allergy herbal formula 2 protection against peanut anaphylactic reaction is via inhibition of mast cells and basophils. J Allergy Clin Immunol. 2010;126:1208–17.PubMedCrossRefGoogle Scholar
  19. 19.
    Pene J, Guglielmi L, Gauchat JF, et al. IFN-gamma-mediated inhibition of human IgE synthesis by IL-21 is associated with a polymorphism in the IL-21R gene. J Immunol. 2006;177:5006–13.PubMedGoogle Scholar
  20. 20.
    Lewkowich IP, Hayglass KT. Endogenous IFN-gamma and Il-18 production directly limit induction of type 2 immunity in vivo. Eur J Immunol. 2002;32:3536–45.PubMedCrossRefGoogle Scholar
  21. 21.
    Kattan JD, Srivastava KD, Zou ZM, et al. Pharmacological and immunological effects of individual herbs in the food allergy herbal formula-2 (FAHF-2) on peanut allergy. Phytother Res. 2008;22:651–9.PubMedCrossRefGoogle Scholar
  22. 22.
    Srivastava K, Sampson HA, Li XM. The traditional Chinese medicine formula FAHF-2 provides complete protection from anaphylaxis in a murine model of multiple food allergy. J Allergy Clin Immunol. 2009;123(2 Suppl):S151.CrossRefGoogle Scholar
  23. 23.
    • Wang J, Patil SP, Yang N, et al. Safety, tolerability, and immunologic effects of a food allergy herbal formula in food allergic individuals: a randomized, double-blinded, placebo-controlled, dose escalation, phase 1 study. Ann Allergy Asthma Immunol. 2010;105:75–84. This was the first clinical trial investigating the safety of TCM for the food allergy.PubMedCrossRefGoogle Scholar
  24. 24.
    • Patil SP, Wang J, Song Y, et al. Clinical safety of food allergy herbal formula-2 (FAHF-2) and inhibitory effect on basophils from patients with food allergy: Extended phase I study. J Allergy Clin Immunol. 2011;128:1259–1265.e2. The results from this extended phase 1 trial demonstrate the long-term safety of FAHF-2 and shows early mechanistic data in humans.PubMedCrossRefGoogle Scholar
  25. 25.
    • Srivastava K, Yang N, Chen Y, et al. Efficacy, safety and immunological actions of butanol-extracted food allergy herbal formula-2 on peanut anaphylaxis. Clin Exp Allergy. 2011;41:582–91. Butanol extracted FAHF-2 achieves the same level of protection against peanut induced anaphylaxis in a murine model as 1/5 the total dose of FAHF-2. Retreatment with B-FAHF-2 re-establishes the protective effects.PubMedCrossRefGoogle Scholar
  26. 26.
    Yamamoto T, Fujiwara K, Yoshida M, et al. Therapeutic effect of kakkonto in a mouse model of food allergy with gastrointestinal symptoms. Int Arch Allergy Immunol. 2009;148:175–85.PubMedCrossRefGoogle Scholar
  27. 27.
    Lopez-Exposito I, Castillo A, Yang N, et al. Chinese herbal extracts of Rubia cordifolia and Dianthus superbus suppress IgE production and prevent peanut-induced anaphylaxis. Chin Med. 2011;6:35.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  1. 1.Division of Allergy and Immunology, Department of PediatricsMount Sinai School of MedicineNew YorkUSA

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