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Current Allergy and Asthma Reports

, Volume 10, Issue 6, pp 389–390 | Cite as

Oseltamivir Treatment for Acute Otitis Media in Children with Influenza

  • David P. SkonerEmail author
Clinical Trial Report

Trial

Winther B, Block SL, Reisinger K, Dutkowski R: Impact of oseltamivir treatment on the incidence and course of acute otitis media in children with influenza. Int J Pediatr Otorhinolaryngol 2010, 74:684–688.

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Introduction

There are many known risk factors for otitis media, including allergy and infection. In particular, experimental upper respiratory infections with rhinovirus, influenza virus, and respiratory syncytial virus produce nasal obstruction, eustachian tube obstruction, and middle ear under-pressures [1, 2, 3]. However, of these three viruses, only influenza virus infection has been linked to direct visual clinical evidence of otitis media [4]. Furthermore, influenza viruses have been isolated from the middle ear fluid of children with acute otitis media infections. Acute otitis media is the most common complication of pediatric influenza and imposes a substantial health care burden. The medical treatment of otitis media has revolved around...

Keywords

Influenza Respiratory Syncytial Virus Otitis Medium Acute Otitis Medium Oseltamivir 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Disclosure

Dr. Skoner has served on the speakers’ bureau for AstraZeneca, Merck & Co., GlaxoSmithKline, and Novartis; has received grant/research support from Novartis and Schering-Plough; and has served as a consultant for Merck & Co.

References

  1. 1.
    Buchman CA, Doyle WJ, Skoner D, et al.: Otologic manifestations of experimental rhinovirus infection. Laryngoscope 1994, 104:1295–1299.PubMedGoogle Scholar
  2. 2.
    Doyle WJ, Skoner DP, Hayden F, et al.: Nasal and otologic effects of experimental influenza A virus infection. Ann Otol Rhinol Laryngol 1994, l03:59–69.Google Scholar
  3. 3.
    Buchman C, Doyle W, Pilcher O, et al.: Nasal and otological effects of experimental respiratory syncytial virus infection in adults. Am J Otolaryngol 2002, 23:70–75.CrossRefPubMedGoogle Scholar
  4. 4.
    Buchman CA, Doyle WJ, Skoner DP, et al.: Influenza A virus-induced acute otitis media. J Infect Dis 1995, 172:1348–1351.PubMedGoogle Scholar
  5. 5.
    Doyle WJ, Skoner DP, Alper CM, et al.: Effect of rimantadine treatment on clinical manifestations and otological complications in adults experimentally infected with influenza A (H1N1) virus. J Infect Dis 1998, 177:1260–1265.CrossRefPubMedGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  1. 1.Drexel University College of MedicinePhiladelphiaUSA
  2. 2.West Virginia University School of MedicineMorgantownUSA
  3. 3.Department of Pediatrics, Division of Allergy, Asthma & ImmunologyAllegheny General HospitalPittsburghUSA

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