Abstract
A family history of an allergic condition is a well-accepted risk factor for the development of an allergic condition in an individual, particularly for allergic disorders such as asthma, eczema, and allergic rhinitis. However, the question of whether specific allergen sensitization is inherited requires a complicated answer, as environmental exposure plays an important role in the development of allergen-specific IgE. This article summarizes the findings of recent studies in the literature regarding what is known about the inheritance of specific allergens. Overall, properly collected and analyzed data appear to both support and refute the hypothesis that specific allergen sensitization is inherited, even when attempting to account for the complexities of varying study methodologies and the evaluation of diverse populations and communities.
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References
Papers of particular interest, published recently, have been highlighted as: • Of importance
Marsh DG, Hsu SH, Roebber M, et al.: HLA-Dw2: a genetic marker for human immune response to short ragweed pollen allergen Ra5 response resulting primarily from normal antigenic exposure. J Exp Med 1982, 155:1439–1451.
Kim Y-K, Oh S-Y, Oh H-B, et al.: Positive association between HLA-DRB1*07 and specific IgE responses to purified major allergens to D. pteronyssinus (Der p 1 and Der p 2). Ann Allergy Asthma Immunol 2002, 88:170–174.
Jeal H, Draper A, Jones M, et al.: HLA associations with occupational sensitization to rat lipocalin allergens: a model for other animal allergies? J Allergy Clin Immunol 2003, 111:795–799.
Donflack J, Tsalenko A, Hoki D, et al.: HLA DRB1*01 alleles are associated with sensitization to cockroach allergens. J Allergy Clin Immunol 2000, 105:960–966.
Liu X, Beaty TH, Deindl P, et al.: Associations between specific serum IgE response and 6 variants within the genes IL4, IL13, IL4RA in German children: the German Multicenter Atopy study. J Allergy Clin Immunol 2004, 113:489–495.
• Canfield SM, Jacobson JS, Perzanowski MS, et al.: Total and specific IgE associations between New York City Head Start children and their parents. J Allergy Clin Immunol 2008, 121:1422–1427. This was one of the first recent cohort studies to examine specific IgE associations in triads of mother, father, and their 4-year-old child recruited from Head Start centers in New York.
• Misiak RT, Wegienka G, Havstad S, et al.: Specific allergic sensitization in parents and their 18-year-old offspring in the suburban Detroit Childhood Allergy Study. J Allergy Clin Immunol 2009, 123:1401–1406. This was one of the first recent cohort studies to examine specific IgE associations in triads of mother, father, and their 18-year-old offspring in the suburban Detroit CAS.
Los H, Postmus PE, Boomsma DI: Asthma genetics and intermediate phenotypes: a review from twin studies. Twin Res 2001, 4:81–93.
Thomsen SF, Kyvik KO, Backer V: Etiological relationships in atopy: a review of twin studies. Twin Res Hum Genet 2008, 11:112–120.
Clarke JR, Jenkins MA, Hopper JL, et al.: Evidence for genetic associations between asthma, atopy, and bronchial hyperresponsiveness. Am J Respir Crit Care Med 2000, 162:2188–2193.
Wuthrich B, Baumann E, Fries RA, et al.: Total and specific IgE (RAST) in atopic twins. Clin Allergy 1981, 11:147–154.
Hopp RJ, Bewtra K, Watt GD, et al.: Genetic analysis of allergic disease in twins. J Allergy Clin Immunol 1984, 73:265–270.
Hanson B, McGue M, Roitman-Johnson B, et al.: Atopic disease and immunoglobulin E in twins reared apart and together. Am J Hum Genet 1991, 48:873–879.
Strachan DP, Wong J, Spector TD: Concordance and interrelationship of atopic diseases and markers of allergic sensitization among adult female twins. J Allergy Clin Immunol 2001, 108:901–907.
Tovey ER, Sluyter R, Duffy DL, et al.: Immunoblotting analysis of twin era provides evidence for limited genetic control of specific IgE to house dust mite allergens. J Allergy Clin Immunol 1998, 101:491–497.
Acknowledgment
The authors would like to acknowledge Dr. Albert Levin’s review of the manuscript and suggestions regarding the interpretation of complex genetic studies.
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Misiak, R.T., Wegienka, G. & Zoratti, E. Are Specific Allergen Sensitivities Inherited?. Curr Allergy Asthma Rep 10, 336–339 (2010). https://doi.org/10.1007/s11882-010-0129-8
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DOI: https://doi.org/10.1007/s11882-010-0129-8