Current Allergy and Asthma Reports

, Volume 10, Issue 1, pp 39–48 | Cite as

Pathogenesis of Allergic Airway Inflammation

Article

Abstract

Advances have been made in defining the mechanisms for the control of allergic airway inflammation in response to inhaled antigens. Several genes, including ADAM33, DPP10, PHF11, GPRA, TIM-1, PDE4D, OPN3, and ORMDL3, have been implicated in the pathogenesis and susceptibility to atopy and asthma. Growing evidence associates asthma with a systemic propensity for allergic T-helper type 2 cytokines. Disordered coagulation and fibrinolysis also exacerbate asthma symptoms. Balance among functionally distinct dendritic cell subsets contributes to the outcome of T-cell-mediated immunity. Allergen-specific T-regulatory cells play a pivotal role in the development of tolerance to allergens and immune suppression. The major emphasis on immunotherapy for asthma during the past decade has been to direct the immune response to a type 1 response, or immune tolerance. In this review, we discuss the current information on the pathogenesis of allergic airway inflammation and potential immunotherapy, which could be beneficial in the treatment of airway inflammation, allergy, and asthma.

Keywords

Allergic airway inflammation Asthma Asthma gene Coagulation system Cytotoxic T cell Dendritic cell Flt3 ligand KCa3.1 Matrix metalloproteinase T helper cell T regulatory cell 

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© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  1. 1.Center for Clinical and Translational ScienceCreighton University School of MedicineOmahaUSA

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