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Current Allergy and Asthma Reports

, Volume 9, Issue 1, pp 81–87 | Cite as

Vitamin D, respiratory infections, and asthma

  • Adit A. Ginde
  • Jonathan M. Mansbach
  • Carlos A. CamargoEmail author
Article

Abstract

Over the past decade, interest has grown in the role of vitamin D in many nonskeletal medical conditions, including respiratory infection. Emerging evidence indicates that vitamin D-mediated innate immunity, particularly through enhanced expression of the human cathelicidin antimicrobial peptide (hCAP-18), is important in host defenses against respiratory tract pathogens. Observational studies suggest that vitamin D deficiency increases risk of respiratory infections. This increased risk may contribute to incident wheezing illness in children and adults and cause asthma exacerbations. Although unproven, the increased risk of specific respiratory infections in susceptible hosts may contribute to some cases of incident asthma. Vitamin D also modulates regulatory T-cell function and interleukin-10 production, which may increase the therapeutic response to glucocorticoids in steroid-resistant asthma. Future laboratory, epidemiologic, and randomized interventional studies are needed to better understand vitamin D’s effects on respiratory infection and asthma.

Keywords

Asthma Respiratory Infection Cord Blood Asthma Exacerbation Maternal Intake 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Adit A. Ginde
  • Jonathan M. Mansbach
  • Carlos A. Camargo
    • 1
    Email author
  1. 1.EMNet Coordinating CenterMassachusetts General HospitalBostonUSA

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