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Fixed drug eruption: A prototypic disorder mediated by effector memory T cells

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Abstract

Effector memory T cells are uniquely specialized to mediate protective immunity. However, their excessive activation may result in the development of organ-specific inflammatory diseases, which have not been extensively studied. Fixed drug eruption (FDE), a localized variant of drug-induced dermatoses characterized by relapse in the same location, is a prototypic disorder mediated by excessive activation of effector memory T cells, which are resident in the lesional epidermis. A variety of clinical and pathologic features uniquely observed in FDE lesions can be explained by the presence of CD8+ intraepidermal T cells with the effector memory phenotype in the FDE lesion. This review focuses on how these T cells are generated, retained in the epidermis, and activated to cause epidermal damage.

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Authors and Affiliations

  1. Department of Dermatology, Kyorin University School of Medicine, 6-20-2 Shinkawa, Mitaka, Tokyo, Japan

    Yoshiko Mizukawa

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  1. Yoshiko Mizukawa
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  2. Tetsuo Shiohara
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Correspondence to Yoshiko Mizukawa.

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Mizukawa, Y., Shiohara, T. Fixed drug eruption: A prototypic disorder mediated by effector memory T cells. Curr Allergy Asthma Rep 9, 71–77 (2009). https://doi.org/10.1007/s11882-009-0011-8

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  • DOI: https://doi.org/10.1007/s11882-009-0011-8

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