Current Allergy and Asthma Reports

, Volume 8, Issue 6, pp 513–518 | Cite as

Gastric pepsin in middle ear fluid of children with otitis media: Clinical implications

  • Zhaoping He
  • Robert C. O’ReillyEmail author
  • Devendra Mehta


Gastroesophageal reflux and extraesophageal reflux have been postulated to be involved in the pathogenesis of otitis media. This is supported by recent studies revealing the presence of gastric pepsin in the middle ear space of children with otitis media but not in control patients without otitis media. Reflux’s role in otitis media appears to be most pronounced in younger children and those with purulent effusions.


Otitis Medium Eustachian Tube Chronic Otitis Medium Eustachian Tube Dysfunction Eustachian Tube Function 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Zhaoping He
  • Robert C. O’Reilly
    • 1
    Email author
  • Devendra Mehta
  1. 1.Division of Pediatric OtolaryngologyAlfred I. duPont Hospital for ChildrenWilmingtonUSA

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