Current Allergy and Asthma Reports

, Volume 6, Issue 3, pp 215–220 | Cite as

Nonallergic rhinitis with eosinophilia syndrome

  • Anne K. Ellis
  • Paul K. KeithEmail author


Nonallergic rhinitis with eosinophilia syndrome (NARES) is a clinical syndrome comprising symptoms consistent with allergic rhinitis in which an absence of atopy has been demonstrated by allergen skin testing, and nasal cytology analysis demonstrates more than 20% eosinophils. Anosmia is a prominent feature not shared with allergic rhinitis. The pathophysiology of NARES is poorly understood, but a key component involves a self-perpetuating, chronic eosinophilic nasal inflammation with development of nasal micropolyposis and polyposis. Mast cells likely play an important role as well. NARES is a risk factor for the development of nasal polyposis and aspirin sensitivity, as well as obstructive sleep apnea. Treatment consists mainly of intranasal corticosteroids with or without the addition of second-generation antihistamines and/or leukotriene-receptor antagonists.


Obstructive Sleep Apnea Rhinitis Allergic Rhinitis Allergic Rhinitis Allergy Clin Immunol 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Current Science Inc 2006

Authors and Affiliations

  1. 1.Clinical Immunology and Allergy, Department of MedicineMcMaster UniversityHamiltonCanada

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