Current Allergy and Asthma Reports

, Volume 5, Issue 1, pp 9–14

Update on beta-lactam allergy diagnosis

  • Pascal Demoly
  • Antonino Romano

DOI: 10.1007/s11882-005-0048-2

Cite this article as:
Demoly, P. & Romano, A. Curr Allergy Asthma Rep (2005) 5: 9. doi:10.1007/s11882-005-0048-2


Allergic reactions to penicillin and cephalosporin antibiotics are common. The mechanisms involved are heterogeneous and not yet completely understood. However, clinical and immunologic studies suggest that type I (IgE-mediated) and type IV (cellmediated) pathogenic mechanisms are involved in most immediate and non-immediate reactions, respectively. The diagnostic procedure has recently been standardized under the aegis of the European Network for Drug Allergy and the European Academy of Allergy and Clinical Immunology interest group on drug hypersensitivity. In this review, we describe the general guidelines for evaluating subjects in whom there is suspicion of allergic reactions to β-lactams.

Copyright information

© Current Science Inc 2005

Authors and Affiliations

  • Pascal Demoly
    • 1
  • Antonino Romano
    • 1
  1. 1.Exploration des Allergies, Maladies Respiratoires, INSERM U454-IFR3, Hôpital Arnaud de VilleneuveUniversity Hospital of MontpellierMontpellier Cedex 5France

Personalised recommendations