Current Allergy and Asthma Reports

, Volume 5, Issue 3, pp 212–220 | Cite as

Pets and the development of allergic sensitization

  • Angela Simpson
  • Adnan Custovic
Article

Abstract

Sensitization to pets remains a risk factor for asthma and rhinitis, and can occur in people who have never lived with a pet. Several reports have indicated that living with a pet reduces the risk for becoming sensitized to that pet. Having a pet in the home gives exposure to more than just allergens. In areas with high frequency of pet ownership, community exposure to pet allergens is almost certainly sufficient to induce sensitization among non-pet owners. In this review, we examine the results of recent studies that have investigated the relationship between pet ownership, specific sensitization to that pet, and allergic sensitization in general. For cat ownership, the results are inconsistent between studies of similar design, with some studies suggesting an increase in risk and others a decrease among cat owners. For dogs, results are more consistent, generally suggesting that owning a dog has no effect or indeed may be protective against the development of specific sensitization to dog and allergic sensitization in general.

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References and Recommended Reading

  1. 1.
    Simpson A, Custovic A: Early pet exposure: friend or foe? Curr Opin Allergy Clin Immunol 2003, 3:7–14.PubMedCrossRefGoogle Scholar
  2. 2.
    Munir AKM, Kjellman M, Bjorksten B: Exposure to indoor allergens in early infancy and sensitisation. J Allergy Clin Immunol 1997, 100:177–181.PubMedCrossRefGoogle Scholar
  3. 3.
    Perzanowski MS, Ronmark E, Platts-Mills TA, Lundback B: Effect of cat and dog ownership on sensitization and development of asthma among preteenage children. Am J Respir Crit Care Med 2002, 166:696–702.PubMedCrossRefGoogle Scholar
  4. 4.
    Roost H-P, Kunzli N, Schindler C, et al.: Role of current and childhood exposure to cat and atopic sensitisation. J Allergy Clin Immunol 1999, 104:941–947.PubMedCrossRefGoogle Scholar
  5. 5.
    Remes ST, Castro-Rodriguez JA, Holberg CJ, et al.: Dog exposure in infancy decreases the subsequent risk of frequent wheeze but not of atopy. J Allergy Clin Immunol 2001; 108:509–515. This Children’s Respiratory Study from Tucson, AZ, has provided a wealth of information on early-life wheezing illness.PubMedCrossRefGoogle Scholar
  6. 6.
    Arshad SH, Tariq SM, Matthews S, Hakim E: Sensitisation to common allergens and its association with allergic disorders at age 4 years: a whole population birth cohort study. Pediatrics 2001, 108:E33.PubMedCrossRefGoogle Scholar
  7. 7.
    Ownby DR, Johnson CC, Peterson EL: Exposure to dogs and cats in the first year of life and risk of allergic sensitisation at age 6 to 7 years. JAMA 2002, 288:963–972. This unselected birth cohort study identified dogs as protective against allergic sensitization.PubMedCrossRefGoogle Scholar
  8. 8.
    Lau S, Illi S, Sommerfeld C, et al.: Early exposure to house dust mite and cat allergens and development of childhood asthma: a cohort study. Lancet 2000, 356:1392–1397.PubMedCrossRefGoogle Scholar
  9. 9.
    Custovic A, Simpson BM, Simpson A, et al.: Effect of environmental manipulation in pregnancy and early life on respiratory symptoms and atopy during first year of life: a randomised trial. Lancet 2001, 358:188–193.PubMedCrossRefGoogle Scholar
  10. 10.
    Burr ML, Merrett TG, Dunstan FDJ, Maguire MJ: The development of allergy in high-risk children. Clin Exp Allergy 1997, 27:1247–1253.PubMedCrossRefGoogle Scholar
  11. 11.
    Gern JE, Reardon CL, Hoffjan S, et al.: Effects of dog ownership and genotype on immune development and atopy in infancy. J Allergy Clin Immunol 2004, 113:307–314. A recent publication putting the exposure to pet allergen in the context of genotype.PubMedCrossRefGoogle Scholar
  12. 12.
    Ronmark E, Jonsson E, Platts-Mills T, Lundback B: Different patterns of risk factors for atopic and non-atopic asthma among children—report from the Obstructive Lung Disease in Northern Sweden Study. Allergy 199, 54:926-935.Google Scholar
  13. 13.
    Hesselmar B, Aberg N, Aberg B, et al.: Does early exposure to cat or dog protect against later allergy development. Clin Exp Allergy 1999, 29:611–617.PubMedCrossRefGoogle Scholar
  14. 14.
    Braback L, Kjellman NI, Sandin A, Bjorksten B: Atopy among school children in northern and southern Sweden in relation to pet ownership and early life events. Pediatr Allergy Immunol 2001, 12:4–10.PubMedCrossRefGoogle Scholar
  15. 15.
    Ritz BR, Hoelscher B, Frye C, et al.: Allergic sensitisation owing to ‘second hand’ cat exposure in schools. Allergy 2002, 57:357–361.PubMedCrossRefGoogle Scholar
  16. 16.
    Holscher B, Frye C, Wichmann HE, Heinrich J: Exposure to pets and allergies in children. Pediatr Allergy Immunol 2002, 13:334–341.PubMedCrossRefGoogle Scholar
  17. 17.
    Anyo G, Brunekreef B, de Meer G, et al.: Early, current and past pet ownership: associations with sensitization, bronchial responsiveness and allergic symptoms in school children. Clin Exp Allergy 2002, 32:361–366.PubMedCrossRefGoogle Scholar
  18. 18.
    Cooper PJ, Chico ME, Rodrigues LC, et al.: Risk factors for atopy among school children in a rural area of Latin America. Clin Exp Allergy 2004, 34:845–852.PubMedCrossRefGoogle Scholar
  19. 19.
    Ingram JM, Sporik R, Rose G, et al.: Quantitative assessment of exposure to dog (Can f 1) and cat (Fel d 1) allergens: relation to sensitization and asthma among children living in Los Alamos. J Allergy Clin Immunol 1995, 96:449–456.PubMedCrossRefGoogle Scholar
  20. 20.
    Sporik R, Squillace SP, Ingram JM, et al.: Mite, cat and cockroach exposure, allergen sensitisation and asthma in children: a case-control study of three schools. Thorax 1999, 54:675–680.PubMedCrossRefGoogle Scholar
  21. 21.
    Platts-Mills T, Vaughan J, Squillace S, et al.: Sensitisation, asthma and a modified Th2 response in children exposed to cat allergen: a population-based cross-sectional study. Lancet 2001, 357:752–756.PubMedCrossRefGoogle Scholar
  22. 22.
    Henriksen AH, Holmen TL, Bjermer L: Sensitization and exposure to pet allergens in asthmatics versus non-asthmatics with allergic rhinitis. Respir Med 2001, 95:122–129.PubMedCrossRefGoogle Scholar
  23. 23.
    Warner JA, Little SA, Pollock I, et al.: The influence of exposure to house dust mite, cat, pollen and fungal allergens in the home on primary sensitisation in asthma. Pediatr Allergy Immunol 1991, 1:79–86.Google Scholar
  24. 24.
    Melen E, Wickman M, Nordvall SL, et al.: Influence of early and current environmental exposure factors on sensitization and outcome of asthma in pre-school children. Allergy 2001, 56:646–652.PubMedCrossRefGoogle Scholar
  25. 25.
    Ichikawa K, Iwasaki E, Baba M, Chapman MD: High prevalence of sensitization to cat allergen among Japanese children with asthma, living without cats. Clin Exp Allergy 1999, 29:754–761.PubMedCrossRefGoogle Scholar
  26. 26.
    Kidon MI, See Y, Goh A, et al.: Aeroallergen sensitization in pediatric allergic rhinitis in Singapore: Is air-conditioning a factor in the tropics? Pediatr Allergy Immunol 2004, 15:340–343.PubMedCrossRefGoogle Scholar
  27. 27.
    Linneberg A, Nielsen NH, Madsen F, et al.: Factors relating to allergic sensitization to aeroallergens in a cross-sectional study in adults. The Copenhagen Allergy Study. Clin Exp Allergy 2001, 31:1409–1417.PubMedCrossRefGoogle Scholar
  28. 28.
    Linneberg A, Nielsen NH, Madsen F, et al.: Pets in the home and the development of pet allergy in adulthood. The Copenhagen Allergy Study. Allergy 2003, 58:21–26.PubMedCrossRefGoogle Scholar
  29. 29.
    Von Linstow ML, Porsbjerg C, Ulrik CS, et al.: Prevalence and predictors of atopy among young Danish adults. Clin Exp Allergy 2002, 32:520–525.CrossRefGoogle Scholar
  30. 30.
    Svanes C, Jarvis D, Chinn S, Burney P: Childhood environment and adult atopy: results from the European Community Respiratory Health Survey. J Allergy Clin Immunol 1999, 103:415–420.PubMedCrossRefGoogle Scholar
  31. 31.
    Svanes C, Heinrich J, Jarvis D, et al.: Pet-keeping in childhood and adult asthma and hay fever: results from the European Community Respiratory Health Survey. J Allergy Clin Immunol 2003, 112:289–300.PubMedCrossRefGoogle Scholar
  32. 32.
    Noertjojo K, Dimich-Ward H, Obata H, et al.: Exposure and sensitisation to cat dander: asthma and asthma-like symptoms in adults. J Allergy Clin Immunol 1999, 103:60–65.PubMedCrossRefGoogle Scholar
  33. 33.
    Custovic A, Hallam CL, Simpson BM, et al.: Decreased prevalence of sensitisation to cats with high exposure to cat allergen. J Allergy Clin Immunol 2001, 108:537–539.PubMedCrossRefGoogle Scholar
  34. 34.
    Dharmage S, Bailey M, Raven J, et al.: Current indoor allergen levels of fungi and cats, but not house dust mites, influence allergy and asthma in adults with high dust mite exposure. Am J Respir Crit Care Med 2001, 164:65–71.PubMedGoogle Scholar
  35. 35.
    Raukas-Kivioja A, Raukas E, Loit HM, et al.: Allergic sensitization among adults in Tallinn, Estonia. Clin Exp Allergy. 2003, 33:1342–1348.PubMedCrossRefGoogle Scholar
  36. 36.
    Oryszczyn MP, Annesi-Maesano I, Charpin D, Kauffmann F: Allergy markers in adults in relation to the timing of pet exposure: the EGEA study. Allergy 2003, 58:1136–1143.PubMedCrossRefGoogle Scholar
  37. 37.
    Desjardins A, Benoit C, Ghezzo H, et al.: Exposure to domestic animals and risk of immunologic sensitization in subjects with asthma. J Allergy Clin Immunol 1993, 91:979–986.PubMedCrossRefGoogle Scholar

Copyright information

© Current Science Inc 2005

Authors and Affiliations

  • Angela Simpson
    • 1
  • Adnan Custovic
    • 1
  1. 1.North West Lung CentreWythenshawe HospitalManchesterUK

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