Skip to main content
SpringerLink
Log in

Animal models of sinusitis: relevance to human disease

  • Published:
Current Allergy and Asthma Reports Aims and scope Submit manuscript

Abstract

Experimental animal models are necessary to assess the efficacy of both medical and surgical procedures. The researcher who wishes to confirm and publish his results must overcome controversies concerning the validity of his model and, therefore, needs guidelines for standardization. Various models are offered in the literature. In this article, the rabbit and murine models of experimental sinusitis and their relevance to human disease with anatomical, histopathologic, and microbiologic aspects are discussed.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

erences and Recommended Reading

  1. Kelemen G: The nasal and paranasal cavities of the rabbit in experimental work. Arch Otolaryngol 1955, 61:497–512.

    CAS  Google Scholar 

  2. Marks SC: Acute rhinogenic sinusitis in the rabbit model. Laryngoscope 1997, 107:1579–1585.

    Article  PubMed  CAS  Google Scholar 

  3. Marks SC: Acute sinusitis in the rabbit model: histologic analysis. Laryngoscope 1998, 108:320–325.

    Article  PubMed  CAS  Google Scholar 

  4. Kara CO, Demirkan N: A review on experimental sinusitis models in rabbits. Kulak Burun Bogaz Ihtis Derg 2003, 10:122–130.

    PubMed  Google Scholar 

  5. Stierna P, Kumlien J, Carlsoo B: Experimental sinusitis in rabbits induced by aerobic and anaerobic bacteria: models for research in sinusitis. J Otolaryngol 1991, 20:376–378.

    PubMed  CAS  Google Scholar 

  6. Stierna P, Soderlund K, Hultman E: Chronic maxillary sinusitis: energy metabolism in sinus mucosa and secretion. Acta Otolaryngol 1991, 111:135–143.

    PubMed  CAS  Google Scholar 

  7. Norlander T, Fukami M, Westrin KM, et al.: Formation of mucosal polyps in the nasal and maxillary sinus cavities by infection. Otolaryngol Head Neck Surg 1993, 109:522–529.

    PubMed  CAS  Google Scholar 

  8. Westrin KM, Stierna P, Carlsoo B, et al.: Mucosal fine structure in experimental sinusitis. Ann Otol Rhinol Laryngol 1993, 102:639–645.

    PubMed  CAS  Google Scholar 

  9. Kara CO, Çetin CB, Colakoglu N, et al.: Experimentally induced rhinosinusitis in rabbits. J Otolaryngol 2002, 31:294–298.

    PubMed  Google Scholar 

  10. Kara CO, Cetin CB, Demirkan N, et al.: Experimental sinusitis in a rhinogenic model. Laryngoscope 2004, 114:273–278. A detailed study on an experimental sinusitis model that can be accomplished without disturbing ostia.

    Article  PubMed  Google Scholar 

  11. Beste DJ, Capper DT, Shaffer K, et al.: Antimicrobial effect on rabbit sinusitis after temporary ostial occlusion. Am J Rhinol 1997, 11:485–489.

    PubMed  CAS  Google Scholar 

  12. Cetin CB, Kara CO, Colakoglu N, et al.: Experimental sinusitis model in nasally catheterized rabbits. Rhinology 2002, 40:154–158.

    PubMed  Google Scholar 

  13. Westergren V, Otori N, Stierna P: Experimental nasal intubation: a study of changes in nasoantral mucosa and bacterial flora. Laryngoscope 1999, 109:1068–1073.

    Article  PubMed  CAS  Google Scholar 

  14. Maeyama T: A study of experimental sinusitis in rabbits. Auris Nasus Larynx 1981, 8:87–98.

    PubMed  CAS  Google Scholar 

  15. Hilding A: Experimental sinus surgery: effects of operative windows on normal sinuses. Ann Otol Rhinol Laryngol 1941, 50:379–392.

    Google Scholar 

  16. Kerschner JE, Cruz MJ, Beste DJ, et al.: Computed tomography vs. magnetic resonance imaging of acute bacterial sinusitis: a rabbit model. Am J Otolaryngol 2000, 21:298–305.

    Article  PubMed  CAS  Google Scholar 

  17. Kennedy CA, Jyonouchi H, Kajander KC, et al.: Middle ear pathologic changes associated with chronic anaerobic sinusitis in rabbits. Laryngoscope 1999, 109:498–503.

    Article  PubMed  CAS  Google Scholar 

  18. Bomer K, Brichta A, Baroody F, et al.: A mouse model of acute bacterial rhinosinusitis. Arch Otolaryngol Head Neck Surg 1998, 124:1227–1232.

    PubMed  CAS  Google Scholar 

  19. Won YS, Brichta A, Baroody F, et al.: Bactrim reduces the inflammatory response in a murine model of acute rhinosinusitis. Rhinology 2000, 38:68–71.

    PubMed  CAS  Google Scholar 

  20. Jacob A, Faddis BT, Chole RA: Chronic bacterial rhinosinusitis: description of a mouse model. Arch Otolaryngol Head Neck Surg 2001, 127:657–664.

    PubMed  CAS  Google Scholar 

  21. Ramadan HH, Meek RB, Dawson GS, et al.: Histologic and immunologic observations of viral-induced rhinosinusitis in the mouse. Am J Rhinol 2002, 16:61–67.

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Otorhinolaryngology and Head Neck Surgery, Pamukkale University, Doktorlar cad 20010, Denizli, Turkey

    Cüneyt O. Kara MD

Authors
  1. Cüneyt O. Kara MD
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kara, C.O. Animal models of sinusitis: relevance to human disease. Curr Allergy Asthma Rep 4, 496–499 (2004). https://doi.org/10.1007/s11882-004-0018-0

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11882-004-0018-0

Keywords

Search

Navigation