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Superantigens and nasal polyps

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Abstract

Nasal polyps represent an often severe T-cell-orchestrated eosinophilic upper airway disease with currently unknown pathogenesis, often associated with lower airway disease, such as asthma. Superantigens, predominantly derived from Staphylococcus aureus, are potent activators of T cells, induce the synthesis of IgE in B cells, and have direct effects on pro-inflammatory cells, such as eosinophils. IgE antibodies to S. aureus enterotoxins have been described in polyp tissue, linked to a local polyclonal IgE production and an aggravation of eosinophilic inflammation. Furthermore, such IgE antibodies have also been described in the sera of patients with asthma, and linked to severity of disease and steroid insensitivity. This review summarizes our current understanding of the possible role of S. aureus enterotoxins in chronic severe airway disease, such as nasal polyposis.

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  1. Department of Otorhinolaryngology, Ghent University Hospital, De Pintelaan 185, 9000, Ghent, Belgium

    Claus Bachert MD, PhD, Thibaut van Zele MD, Philippe Gevaert MD, Lore De Schrijver MD & Paul Van Cauwenberge MD, PhD

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Bachert, C., van Zele, T., Gevaert, P. et al. Superantigens and nasal polyps. Curr Allergy Asthma Rep 3, 523–531 (2003). https://doi.org/10.1007/s11882-003-0065-y

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