Conclusions
As is evident from the foregoing discussion in this article, there is increasing evidence that a particular type of autoimmune reaction, directed against the Fc-epsilon RI, and less commonly against IgE, might be pathogenic in many cases of apparent CIU. The stimulus for this autoimmune response is currently unknown. Most of the evidence for an association of CU with certain systemic diseases is circumstantial, based on epidemiologic findings of an associated prevalence and possibly on the results of therapy directed at the systemic condition. If such associations truly occur, the underlying pathogenic mechanisms are obscure. Hopefully, further investigation will elucidate these relationships and possibly aid in the understanding of the pathogenesis of CIU itself.
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Zweiman, B. Chronic urticaria and systemic diseases. Curr Allergy Asthma Rep 3, 455–457 (2003). https://doi.org/10.1007/s11882-003-0050-5
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DOI: https://doi.org/10.1007/s11882-003-0050-5