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Ocular allergies

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Abstract

Ocular allergic disease affects not only the conjunctivae but also surrounding structures including the eyelids. Allergic diseases of the eyelid include atopic dermatitis, contact dermatitis, and urticaria/angioedema. They must be differentiated from nonallergic eyelid diseases. Allergic diseases of the conjunctivae comprise a spectrum of disorders from common, non-sight-threatening conditions such as seasonal allergic conjunctivitis, perennial allergic conjunctivitis, and giant papillary conjunctivitis to less common and potentially sight-threatening diseases such as vernal keratoconjunctivitis and atopic keratoconjunctivitis. Each of these conditions is mediated primarily by type I hypersensitivity reactions. The clinical manifestations, differential diagnosis, and treatment of these conditions are reviewed in this article.

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References and Recommended Reading

  1. Donshik P, Hoss D, Ehlers W: Inflammatory and papulosquamous disorders of the skin and eye. Dermatol Clin 1992, 10:533–547.

    PubMed  CAS  Google Scholar 

  2. Meenan FOC: The significance of Morgan’s fold in children with atopic dermatitis. Acta Derm Venereol Suppl (Stockh) 1980, 12:42–43.

    Google Scholar 

  3. Uehara M: Infra-orbital fold in atopic dermatitis. Arch Dermatol 1981, 117:627–629.

    Article  PubMed  CAS  Google Scholar 

  4. Mevorah B: Minor clinical features of atopic dermatitis: evaluation of their clinical significance. Dermatologica 1988, 177:360–364.

    Article  PubMed  CAS  Google Scholar 

  5. Nethercott JR, Nield G, Holness DL: A review of 79 cases of eyelid dermatitis. J Am Acad Dermatol 1989, 21:223–230.

    Article  PubMed  CAS  Google Scholar 

  6. Romaguera C, Grimalt F: Dermatitis from nickel eyelash curler. Contact Dermatitis 1985, 12:174.

    Google Scholar 

  7. Cronin E: Contact Dermatitis. New York: Churchill Livingston; 1980.

    Google Scholar 

  8. Maibach H, Engasser P, Ostler B: Upper eyelid dermatosis syndrome. Dermatol Clin 1992, 10:549–554.

    PubMed  CAS  Google Scholar 

  9. Burton JL, Harrad RA: The skin and the eyes. In Textbook of Dermatology edn 6. Edited by Rook A, Wilkinson DS, Ebling FJG. Oxford: Blackwell Science; 1998:2975–2983.

    Google Scholar 

  10. Jenkins MS, Brown SI, Lempert SL, et al.: Ocular rosacea. Am J Ophthalmol 1979, 88:618–622.

    PubMed  CAS  Google Scholar 

  11. Browning DJ, Proia AD: Ocular rosacea. Surv Ophthalmol 1986, 31:145–158.

    Article  PubMed  CAS  Google Scholar 

  12. Borrie P: Rosacea with special reference to its ocular manifestations. Br J Dermatol 1953, 65:458–463.

    Article  PubMed  CAS  Google Scholar 

  13. Stuart JA: Ocular psoriasis. Am J Ophthalmol 1963, 55:615.

    PubMed  CAS  Google Scholar 

  14. Bielory L: Allergic and immunologic disorders of the eye. In Allergy Principles and Practice edn 5. Middleton E Jr, Reed CE. St. Louis: Mosby; 1998. This is an excellent and comprehensive review of the diagnosis, treatment, and pathophysiology of ocular allergic diseases.

    Google Scholar 

  15. Abelson MB, Udell IJ: Allergic and toxic reactions. In Principles and Practice of Ophthalmology edn 2. Edited by Alberts DM, Jakobiec FA. Philadelphia: WB Saunders; 1999. This is another excellent review of ocular allergic and toxic reactions, with more of a discussion of pathophysiologic mechanisms, inflammatory cells, and inflammatory mediators.

    Google Scholar 

  16. Bielory L, Frohman L: Allergic and immunologic disorders of the eye. J Allergy Clin Immunol 1992, 86:1–15.

    Article  Google Scholar 

  17. Ehlers WH, Donshik PC: Allergic ocular disorders: a spectrum of diseases. CLAO J 1992, 18:117–124.

    PubMed  CAS  Google Scholar 

  18. Bielory L: Allergic and immunologic disorders of the eye: Part I: immunology of the eye. J Allergy Clin Immunol 2000, 106:805–816.

    Article  PubMed  CAS  Google Scholar 

  19. Bielory L: Allergic and immunologic disorders of the eye: Part II: ocular allergy. J Allergy Clin Immunol 2000, 106:1019–1032.

    Article  PubMed  CAS  Google Scholar 

  20. Dart JKG, Buckley RJ, Monnickendan M, Prasad J: Perennial allergic conjunctivitis: definition, clinical characteristics and prevalence: a comparison with seasonal allergic conjunctivitis. Trans Ophthalmol Soc U K 1986, 105:513–520.

    PubMed  Google Scholar 

  21. Freidlander MH, Okumuto M, Kelley J: Diagnosis of allergic conjunctivitis. Arch Ophthalmol 1984, 102:1198–1199.

    Google Scholar 

  22. Friedlander MH: Allergic conjunctivitis. In Cornea: Clinical Diagnosis and Management. Edited by Krachmer JH, Mannis MJ, Holland EJ. St. Louis: Mosby; 1997.

    Google Scholar 

  23. Kari O, Salo OP, Bjorksten F, et al.: Allergic conjunctivitis total and specific IgE in the tear fluid. Acta Ophthalmol 1986, 63:97–99.

    Google Scholar 

  24. Sen DK, Sarin GS: Immunoglobulin concentrations in human tears in ocular diseases. Br J Ophthalmol 1979, 63:297–300.

    PubMed  CAS  Google Scholar 

  25. Bonini S, Bonini S, Lambiase A, et al.: Vernal keratoconjunctivitis revisited. Ophthalmology 2000, 107:1157–1163. This is a large case series of VKC patients, with an emphasis on results of long-term follow-up.

    Article  PubMed  CAS  Google Scholar 

  26. Abelson MB, Baird RS, Allansmith MR: Tear histamine levels in vernal conjunctivitis and other ocular inflammations. Ophthalmology 1980, 87:812–814.

    PubMed  CAS  Google Scholar 

  27. Rapuano CJ, Luchs JI, Kim T: The Requisites in Ophthalmology: Anterior Segment. St. Louis: Mosby; 2000.

    Google Scholar 

  28. Ballow M, Donshik PC, Mendelson L, et al.: IgG specific antibodies to rye grass and ragweed pollen antigens in tear secretions of patients with vernal conjunctivitis. Am J Ophthalmol 1983, 95:161–168.

    Article  PubMed  CAS  Google Scholar 

  29. Abelson MB, Leonardi AA, Smith LM, et al.: Histamine activity in patients with vernal keratoconjunctivitis. Ophthalmology 1995, 102:1958–1963.

    PubMed  CAS  Google Scholar 

  30. Abelson MB, Butrus SI, Weston J: Aspirin therapy in vernal conjunctivitis. Am J Ophthalmol 1992, 95:502–505.

    Google Scholar 

  31. Secchi AG, Tognon MS, Leonardi A: Topical use of cyclosporine in vernal keratoconjunctivitis. Am J Ophthalmol 1990, 1120:641–645.

    Google Scholar 

  32. BenEzra D, Peter J, Brosky M, et al.: Cyclosporine eye drops the treatment of severe vernal keratoconjunctivitis. Am J Ophthalmol 1986, 101:278–282.

    PubMed  CAS  Google Scholar 

  33. Bleik JH, Tabbara KF: Topical cyclosporine in vernal keratoconjunctivitis. Ophthalmology 1991, 98:1679–1684.

    PubMed  CAS  Google Scholar 

  34. Foster CS, Cologne M: Atopic keratoconjunctivitis. Ophthalmology 1990, 97:992.

    PubMed  CAS  Google Scholar 

  35. Tuft SJ, Kemeny DM, Dart JK, et al.: Clinical features of atopic keratoconjunctivitis. Ophthalmology 1991, 98:150.

    PubMed  CAS  Google Scholar 

  36. Garrity JA, Liesegang TJ: Ocular complications of atopic dermatitis. Can J Ophthalmol 1984, 19:21–24.

    PubMed  CAS  Google Scholar 

  37. Foster CS, Rice BA, Dutt JE: Immunopathology of atopic keratoconjunctivitis. Ophthalmology 1991, 98:1190.

    PubMed  CAS  Google Scholar 

  38. McGeady SJ, Buckley RH: Depression of cell-mediated immunity in atopic eczema. J Allergy Clin Immunol 1975, 56:393.

    Article  PubMed  CAS  Google Scholar 

  39. Rachelefsky GS: Defective T cell function in atopic dermatitis. J Allergy Clin Immunol 1976, 57:569.

    Article  PubMed  CAS  Google Scholar 

  40. Dermatologic preparations. In American Medical Association Drug Evaluations edn 6. Chicago: American Medical Association; 1986.

  41. Abelson MB, Richard K: What we know and don’t know about GPC. Rev Ophthalmol 1994, 1:664–665.

    Google Scholar 

  42. Greiner JV, Fowler SA, Allansmith MR: Giant papillary conjunctivitis. In Contact Lenses: The CLAO Guide to Basic Science and Clinical Practice. Edited by Dabezies OH Jr. New York: Grune & Stratton; 1984:43.1–43.16.

    Google Scholar 

  43. Allansmith MR, Korb DR, Greiner JV: Giant papillary conjunctivitis induced by hard or soft contact lenses: quantitative histology. Ophthalmology 1978, 85:766–778.

    PubMed  CAS  Google Scholar 

  44. Donshik PC, Ballow M: Tear immunoglobulins in giant papillary conjunctivitis induced by contact lens. Am J Ophthalmol 1983, 96:460–466.

    PubMed  CAS  Google Scholar 

  45. Wasserman SI: Mediators of immediate hypersensitivity. J Allergy Clin Immunol 1983, 72:101–115.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. SUNY at Stony Brook, Winthrop-University Hospital, 222 Station Plaza North, Suite 430, 11501, Mineola, NY, USA

    Luz Fonacier MD, Jodi Luchs MD & Ira Udell MD

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  1. Luz Fonacier MD
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  2. Jodi Luchs MD
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  3. Ira Udell MD
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Fonacier, L., Luchs, J. & Udell, I. Ocular allergies. Curr Allergy Asthma Rep 1, 389–396 (2001). https://doi.org/10.1007/s11882-001-0053-z

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  • DOI: https://doi.org/10.1007/s11882-001-0053-z

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