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Long-term indoor VOC concentrations assessment a trend analysis of distribution, disposition, and personal exposure in cohort study samples

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Abstract

Inhalation is one of the entry ports for different chemicals into the human body. In order to investigate this application route and its negative health effect to humans, the presence of volatile organic compounds (VOCs) in indoor air is monitored since many years. To assess global trends and changes of the distribution and disposition of VOCs and the corresponding personal exposure, this study analyzed annual indoor air concentrations collected over a period of 9 (2006–2014) years in the context of a birth control cohort study of 72 VOCs. Additionally, Short Time-series Expression Model (STEM) was used to identify certain correlation for VOCs from different compound classes. For ~42 % of the compounds, a tendency to lower annual median indoor air concentrations was found, and for ~10 % of the VOCs, a trend to higher annual median indoor air concentrations. No such tendencies were observed for ~22 % of the investigated compounds. For ~26 % of the VOCs, the applied linear regression model was not suitable to predict global trends as annual median values were not linearly distributed. Mann-Kendall test was used to (i) confirm the results from the linear regression model and to (ii) calculate trends for those compounds, where linear regression was found to be unsuitable. Thus, for only approximately four of the investigated VOCs, no prediction was possible using both statistical approaches. STEM analysis revealed the connection of benzene, ethylbenzene, m+p xylene, α-pinene, 3-carene, pentadecane, and decamethlycyclopentasiloxane, in addition to the correlation of 1-butanol, chlorobenzene, heptanal, and 2-ethyl-1-hexanol concentrations.

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Acknowledgements

The authors thank Sven Baumann, Soeren Grunwald, Gabriele Heimpold, Jacqueline Kobelt, Melanie Nowak, Maxie Rockstroh, Carolin Roesch, and Ulrike E. Rolle-Kampczyk for their help and support.

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Authors and Affiliations

  1. Department of Molecular Systems Biology, Helmholtz Centre for Environmental Research—UFZ, Leipzig, Germany

    D. K. Wissenbach, B. Winkler, W. Otto, A. Müller, H. Hoeke & M. von-Bergen

  2. Institute of Forensic Medicine, University Hospital Jena, Jena, Germany

    D. K. Wissenbach

  3. Department of Environmental Immunology, Helmholtz Centre for Environmental Research—UFZ, Leipzig, Germany

    T. Kohajda

  4. Eurofins Institute Dr. Appelt, Leipzig, Germany

    T. Kohajda

  5. Department of Environmental Immunology, Helmholtz Centre for Environmental Research—UFZ, Leipzig, Germany

    S. Roeder & I. Lehmann

  6. Department of Pharmaceutical and Medicinal Chemistry, Institute of Pharmacy, University of Leipzig, Leipzig, Germany

    H. Hoeke

  7. Department of Clinical Chemistry and Laboratory Medicine, University of Regensburg, Regensburg, Germany

    S. Matysik

  8. Department of Urban and Environmental Sociology, UFZ—Helmholtz Centre for Environmental Research, Leipzig, Germany

    U. Schlink

  9. Children’s Hospital, Municipal Hospital St. Georg Leipzig, affiliated to the University of Leipzig, Leipzig, Germany

    M. Borte

  10. Faculty of Medicine, Environmental Medicine, and Hygiene, University of Leipzig, Leipzig, Germany

    O. Herbarth

  11. Department of Biotechnology, Chemistry, and Environmental Engineering, Aalborg University, Aalborg, Denmark

    M. von-Bergen

  12. Institute of Biochemistry, Faculty of Biosciences, Pharmacy, and Psychology, University of Leipzig, Leipzig, Germany

    M. von-Bergen

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  1. D. K. Wissenbach
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  2. B. Winkler
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  3. W. Otto
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  4. T. Kohajda
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  5. S. Roeder
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  6. A. Müller
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  7. H. Hoeke
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  8. S. Matysik
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  9. U. Schlink
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  11. O. Herbarth
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  13. M. von-Bergen
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Correspondence to D. K. Wissenbach.

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Wissenbach, D.K., Winkler, B., Otto, W. et al. Long-term indoor VOC concentrations assessment a trend analysis of distribution, disposition, and personal exposure in cohort study samples. Air Qual Atmos Health 9, 941–950 (2016). https://doi.org/10.1007/s11869-016-0396-1

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  • DOI: https://doi.org/10.1007/s11869-016-0396-1

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