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Systemic Therapy in Advanced Pleomorphic Liposarcoma: a Comprehensive Review

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Opinion statement

The therapeutic approach of pleomorphic liposarcoma (PLPS), a rare high-grade subgroup of soft tissue sarcoma, is commonly extrapolated from the management of other LPS subtypes. Only published retrospective data on PLPS currently serve as a guide for oncologists without clear recommendations or specific guidelines. In the advanced setting, specific systemic therapy such as eribulin and trabectedin showed promising activity in comparison to conventional therapy (doxorubicin- and gemcitabine-based protocols), which currently remains the current standard of care at initial stages of the disease. The better understanding of soft tissue sarcoma (STS) pathophysiology and disease course has led to the development of adapted clinical trial designs for rare STS histotypes with specific treatment approach.

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Authors and Affiliations

  1. Sarcoma Unit, Department of Cancer Medicine, Gustave Roussy Cancer Campus, 114, Rue Edouard Vaillant, Villejuif, France

    Tarek Assi MD, Carine Ngo MD, PHD, Matthieu Faron MD, PHD, Benjamin Verret MD, PHD, Antonin Lévy MD, Charles Honoré MD, PHD, Clémence Hénon MD, PHD, Cécile Le Péchoux MD, Rastilav Bahleda MD & Axel Le Cesne MD

  2. Oncostat U1018, Inserm, Université Paris-Saclay, Equipe Labellisée Ligue Contre le Cancer, Villejuif, France

    Matthieu Faron MD, PHD

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  1. Tarek Assi MD
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Assi, T., Ngo, C., Faron, M. et al. Systemic Therapy in Advanced Pleomorphic Liposarcoma: a Comprehensive Review. Curr. Treat. Options in Oncol. 24, 1598–1613 (2023). https://doi.org/10.1007/s11864-023-01139-3

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