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Management of Non-small Cell Lung Cancer Patients with MET Exon 14 Skipping Mutations

Current Treatment Options in Oncology volume 21, Article number: 33 (2020) Cite this article

Opinion statement

The MET exon 14 skipping mutation is found in approximately 3% of lung adenocarcinomas and slightly more than 2% of lung squamous cell carcinomas. In recent years, more and more evidence has shown that MET inhibitors have achieved good anti-tumor effect in patients with MET exon 14 skipping mutation, suggesting that MET exon 14 skipping mutation may be a new target for NSCLC patients. Patients with positive MET exon 14 skipping mutation are recommended to be administered MET inhibitors, and crizotinib is recommended by the NCCN guideline. Due to the presence of gene amplification, second site mutation, bypass activation, and pathological type transformation, one of the inevitable problems of targeted therapy is drug resistance. If type I MET inhibitors (crizotinib, capmatinib, tepotinib, savolitinib) drug resistance is developed, type II MET inhibitors (cabozantinib, glesatinib, merestinib) can be considered.

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  1. Caiwen Huang and Qihua Zou contributed equally to this work.

Affiliations

  1. Department of Medical Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, 510060, China

    Caiwen Huang MD, Qihua Zou MD & Ying Liang MD, PhD

  2. Department of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, 510060, China

    Hui Liu MD, PhD, Bo Qiu MD & Qiwen Li MD

  3. Department of Thoracic Surgery, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, 510060, China

    Yongbin Lin MD, PhD

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Huang, C., Zou, Q., Liu, H. et al. Management of Non-small Cell Lung Cancer Patients with MET Exon 14 Skipping Mutations. Curr. Treat. Options in Oncol. 21, 33 (2020). https://doi.org/10.1007/s11864-020-0723-5

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Keywords

  • MET exon 14 skipping mutation
  • Tyrosine kinase inhibitor
  • Non-small cell lung cancer
  • Targeted therapy
  • Clinical trial