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Systemic Therapies for Metastatic Pancreatic Neuroendocrine Tumors

  • Neuroendocrine Cancers (JR Strosberg, Section Editor)
  • Published:
Current Treatment Options in Oncology Aims and scope Submit manuscript

Opinion statement

Over the years, there have been significant advances in systemic treatments for metastatic pancreatic neuroendocrine tumors (panNETs). Despite these advancements, uncertainty remains regarding how to best sequence available therapies. For well-differentiated and metastatic panNETs that are somatostatin receptor (SSTR) avid on functional imaging, first-line therapy typically consists of somatostatin analogs (SSAs), given their favorable toxicity profile and overall low burden for patients. When progression of disease is observed on an SSA, multiple treatment options are available, including the targeted agents everolimus and sunitinib, peptide receptor radionuclide therapy (PRRT), as well as chemotherapy, with the latter often preferred for those panNETs of heavy tumor burden, higher grade, and/or more aggressive behavior clinically and/or radiographically. Here, we review panNET classification, currently available systemic treatments, therapy sequencing, and areas of active investigation to further our treatments for the disease.

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Authors and Affiliations

  1. Gastrointestinal Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, 300 E66th Street, New York, NY, 10065, USA

    Haley Hauser BA & Nitya Raj MD

  2. ABC Medical Center, Sur 136 # 116, Colonia Las Américas, Delegación Álvaro Obregón, 01120, Ciudad de México, Mexico

    Daniela Shveid Gerson MD

  3. Chief of Clinical Operations, Gastrointestinal Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, 300 E66th Street, New York, NY, 10065, USA

    Diane Reidy-Lagunes MD

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Hauser, H., Gerson, D.S., Reidy-Lagunes, D. et al. Systemic Therapies for Metastatic Pancreatic Neuroendocrine Tumors. Curr. Treat. Options in Oncol. 20, 87 (2019). https://doi.org/10.1007/s11864-019-0690-x

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