The 2016 revision of the WHO classification of lymphoid neoplasms includes new entities along with a clearer definition of provisional and definitive subtypes based on better understanding of the molecular drivers of lymphomas. These changes impact current treatment paradigms and provide a framework for future clinical trials. Additionally, this update recognizes several premalignant or predominantly indolent entities and underscores the importance of avoiding unnecessarily aggressive treatment in the latter subsets.
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Conflict of Interest
The authors declare that they have no conflict of interest.
Human and Animal Rights and Informed Consent
Although no new studies with human or animal subjects were performed by the authors for this article, this article does contain two cited studies (references 37 and 99) where Dr. Advani was a coinvestigator.
The original version of this article was revised: The heading of the second column of Table 2 was incorrect. Instead of “What’s New”, the heading captured was “Clinical Entity”, which also is the heading of the first column.
This article is part of the Topical Collection on Lymphoma
An erratum to this article is available at https://doi.org/10.1007/s11864-017-0499-4.
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Lynch, R.C., Gratzinger, D. & Advani, R.H. Clinical Impact of the 2016 Update to the WHO Lymphoma Classification. Curr. Treat. Options in Oncol. 18, 45 (2017). https://doi.org/10.1007/s11864-017-0483-z
- Non-Hodgkin lymphoma
- Chronic lymphocytic leukemia (CLL)
- Lymphoplasmacytic lymphoma
- Waldenström macroglobulinemia
- Follicular lymphoma
- Mantle cell lymphoma
- Diffuse large B cell lymphoma (DLBCL)
- BCL6 translocations
- Double hit lymphoma
- Burkitt lymphoma
- High grade B cell lymphoma NOS
- ALK-negative anaplastic large cell lymphoma (ALCL)