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Sentinel Lymph Node Biopsy in Melanoma

  • Melanoma and Skin Tumors
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Current Treatment Options in Oncology Aims and scope Submit manuscript

Opinion statement

Sentinel lymph node biopsy (SLNB) for patients with newly diagnosed localized invasive melanoma provides excellent prognostic information and results in improved regional disease control. Prior to the common use of SLNB, regional nodal recurrence was the single most common site of melanoma recurrence, with symptomatic, bulky disease that could be disabling and difficult or impossible to control. With the widespread use of SLNB, regional recurrence of melanoma is much less frequent. Even without clear evidence of improvement in overall survival, the significant and reliable prognostic information and the improved regional control make sentinel node biopsy an important procedure that should be offered routinely to many patients with newly diagnosed melanoma.

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References

  1. Jemal A, Siegel R, Ward E. et al Cancer statistics, 2008. CA Cancer J Clin 2008, 58:71–96 doi:10.3322/CA.2007.0010

    Article  PubMed  Google Scholar 

  2. Morton DL, Thompson JF, Cochran AJ, et al. (2006) Sentinel-node Biopsy or Nodal Observation in Melanoma. New England Journal of Medicine 355(13):1307–1317 doi:10.1056/NEJMoa060992

    Article  PubMed  CAS  Google Scholar 

  3. Zettersten E, Shaikh L, Ramirez R, et al Prognostic factors in primary cutaneous melanoma. Surg Clin NA 2003, 83:61–75. doi:10.1016/S0039-6109(02)00094-4

    Article  PubMed  Google Scholar 

  4. Gershenwald JE, Thomson W, Mansfield PF et al Multiinstitutional melanoma lymphatic mapping experience: the prognostic value of sentinel lymph node status in 612 stage I or II melanoma patients. J Clin Oncol 1999, 17:976–83

    PubMed  CAS  Google Scholar 

  5. Balch CM, Soong SJ, Gershenwald JE, et al Prognostic factors analysis of 17,600 melanoma patients: validation of the American Joint Committee on Cancer melanoma staging system. J Clin Oncol 2001, 19:3622–34

    PubMed  CAS  Google Scholar 

  6. Balch CM, Buzaid AC, Soong SJ, et al. Final version of the American Joint Committee on Cancer staging system for cutaneous melanoma. J Clin Oncol 2001, 19:3635–48

    PubMed  CAS  Google Scholar 

  7. Dessureault S, Soong SJ, Ross MI, et al. (2001) Improved staging of node-negative patients with intermediate to thick melanomas (>1mm) with the use of lymphatic mapping and sentinel lymph node biopsy. Ann Surg Oncol 8:766–70 doi:10.1007/s10434-001-0766-1

    Article  PubMed  CAS  Google Scholar 

  8. Leong SP, Kashani-Sabeet M, Desmond RA, et al Clinical significance of occult metastatic melanoma in sentinel lymph nodes and other high-risk factors based on long-term follow-up. World J Surg 2005, 29:683–91 doi:10.1007/s00268-005-7736-x

    Article  PubMed  Google Scholar 

  9. Statius Mullet MG, Van Leeuwen PA, deLange-deKlerk ES, et al. The sentinel lymph node status is an important factor for predicting clinical outcome in patients with stage I or II cutaneous melanoma. Cancer 2001 91: 2401–8 doi:10.1002/1097-0142(20010615)91:12<2401::AID-CNCR1274>3.0.CO;2-I

    Google Scholar 

  10. Morton DL, Wen DR, Wong JH, et al Technical details of intraoperative lymphatic mapping for early stage melanoma. Arch Surg 1992, 127:392–9

    PubMed  CAS  Google Scholar 

  11. Thompson JF, McCarthy WH, Bosch CM, et al. Sentinel lymph node status as an indicator of the presence of metastatic melanoma in regional lymph nodes. Mel Res 1995, 5:255–60. doi:10.1097/00008390-199508000-00008

    Article  PubMed  CAS  Google Scholar 

  12. Reintgen D, Cruse CW, Wells K, et al. The orderly progression of melanoma nodal metastases. Ann Surg 1994, 220:759–67 doi:10.1097/00000658-199412000-00009

    Article  PubMed  CAS  Google Scholar 

  13. Krag DN, Meijer SJ, Weaver DL, et al. Minimal access surgery for staging of malignant melanoma Arch Sirg 1995;130:654–8.

    PubMed  CAS  Google Scholar 

  14. Leong SP, Steinmetz I, Habib FA, et al. Optimal selective sentinel lymph node dissection in primary malignant melanoma. Arch Surg 1997;132:666–72

    PubMed  CAS  Google Scholar 

  15. Alex JC, Weaver DL, Fairbank JT, et al. Gamma probe guided lymph node localization in malignant melanoma. Surg Oncol 1993;2:303–8 doi:10.1016/S0960-7404(06)80006-X

    Article  PubMed  CAS  Google Scholar 

  16. Gershenwald JE, Tseng CH, Thompson W, et al Improved sentinel lymph node localization in patients with primary melanoma with the use of radiolabelled colloid. Surgery 1998;124:203–10

    PubMed  CAS  Google Scholar 

  17. McMasters KM, Noyes RD, Reintgen DS, et al. Lessons learned from the Sunbelt Melanoma Trial. J Surg Oncol 2004;86:212–23 doi:10.1002/jso.20084

    Article  PubMed  Google Scholar 

  18. Baisden, BL, Askin FB, Lange JR, et al. HMB-45 immunohistochemical staining of sentinel lymph nodes: a specific method for enhancing detection of micrometastases in patients with melanoma. Am J Surg Pathol 2000, 24:1140–6 doi:10.1097/00000478-200008000-00012

    Article  PubMed  CAS  Google Scholar 

  19. Scheri RP, Essner R, Turner RR, et al. Isolated tumor cells in the sentinel node affect long-term prognosis of patients with melanoma. Ann Surg Oncol 2007, 14:2861–6

    Article  PubMed  Google Scholar 

  20. Rousseau DL, Ross MI, Johnson MM, et al. Revised American Joint Committee on Cancer staging criteria accurately predict sentinel lymph node positivity in clinically node-negative melanoma patients. Ann Surg Oncol 2003;10:569–74 doi:10.1245/ASO.2003.09.016

    Article  PubMed  Google Scholar 

  21. Wong SL, Brady MS, Busam KJ, et al. Results of sentinel lymph node biopsy in patients with thin melanoma. Ann Surg Oncol 2006;13:302–9 doi:10.1245/ASO.2006.02.021

    Article  PubMed  Google Scholar 

  22. Houghton AN, Coit DG, Daud A, et al. Melanoma JNCCN 2006;4:666–84.

    PubMed  Google Scholar 

  23. Chao C, Wong SL, Ross MI, et al. Patterns of early recurrence after sentinel lymph node biopsy for melanoma. Am J Surg 2002;184: 520–4 doi:10.1016/S0002-9610(02)01102-9

    Article  PubMed  Google Scholar 

  24. Vuylsteke RJ, van Leeuwen PA, Statius Muller MG, et al. Clincal outcome of stage I/II melanoma patients after selective sentinel lymph node dissection: long-term follow-up results. J Clin Oncol 2003, 21:1057–65 doi:10.1200/JCO.2003.07.170

    Article  PubMed  CAS  Google Scholar 

  25. Wagner JD, Ranieri J, Evdokimow DZ, et al. Patterns of initial recurrence and prognosis after sentinel lymph node biopsy and selective lymphadenecotmy for melanoma. Plast Reconstr Surg 2003;112:486–97 doi:10.1097/01.PRS.0000070989.23469.1F

    Article  PubMed  Google Scholar 

  26. Zogakis TG, Essner R, Wang H, et al. Natural History of Melanoma in 773 Patients with Tumor-Negative Sentinel Lymph Nodes. Annals of Surgical Oncology, 2005;14(5):1604–1611. doi:10.1245/s10434-006-9267-6

    Article  Google Scholar 

  27. Wong SL, Morgon DL, Thompson JF, et al. Melanoma patient with positive sentinel nodes who did not undergo completion lymphadenectomy: a multiinstitutional study. Ann Surg Oncol 2006;13:809–16 doi:10.1245/ASO.2006.03.058

    Article  PubMed  Google Scholar 

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Correspondence to Julie R. Lange MD, ScM.

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Hueman, M.T., Lange, J.R. Sentinel Lymph Node Biopsy in Melanoma. Curr. Treat. Options in Oncol. 9, 243–250 (2008). https://doi.org/10.1007/s11864-008-0074-0

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  • DOI: https://doi.org/10.1007/s11864-008-0074-0

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