Skip to main content

Advertisement

SpringerLink
Log in

Management of paranasal sinus malignancy

  • Published:
Current Treatment Options in Oncology Aims and scope Submit manuscript

Abstract

Opinion statement Malignancies of the nasal cavity and paranasal sinuses represent a wide spectrum of histologies, tissues of origin, and anatomic primary sites. The inherent difficulty in generalizing treatment approaches is obvious, given the numerous variables associated with the broadly-based term, paranasal sinus malignancy (PNSCa). Nevertheless, the majority of epithelial and salivary malignancies of this region (ie, squamous cell carcinoma, adenocarcinoma, adenoid cystic carcinoma, sinonasal undifferentiated carcinoma, and esthesioneuroblastoma) require surgical intervention as part of any treatment regimen. Recent trends have broadened the indications for chemotherapeutic and radiotherapeutic options in the management of advanced PNSCa. Nonepithelial malignancies, including the wide variety of sarcomas arising in this region, most commonly require multimodality treatment including chemotherapy, radiation, and/or surgery for definitive treatment. Moreover, the proximity of the nasal cavity and paranasal sinuses to structures including the orbit, dura, brain, cranial nerves, and carotid arteries mandates careful radiologic and neurologic evaluations throughout the course of the disease. Surgical advances now permit complex tumor removal and reconstruction surrounding these structures resulting in functional and cosmetic improvements when compared to earlier techniques. However, additional clinical trials are necessary to systematically evaluate the locoregional control, organ-preservation strategies, and survival related to the variety of treatments currently available.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Subscribe and save

Springer+ Basic
$34.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or eBook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References and Recommended Reading

  1. Batsakis JG: The pathology of head and neck tumors: nasal cavity and paranasal sinuses, part 5. Head Neck 1980, 2:410–419.

    Article  CAS  Google Scholar 

  2. Batsakis JG, Rice DH, Solomon AR: The pathology of head and neck tumors: squamous and mucous-gland carcinomas of the nasal cavity, paranasal sinuses, and larynx, part 6. Head Neck 1980, 2:497–508.

    Article  CAS  Google Scholar 

  3. Carrau RL, Myers RM, Johnson JT: Paranasal sinus carcinoma—diagnosis, treatment, and prognosis. Oncology (Huntingt) 1992, 6:43–50.

    CAS  Google Scholar 

  4. Resto VA, Deschler DG: Sinonasal malignancies. Otolaryngol Clin North Am 2004, 37:473–487. An excellent review article of sinonasal malignancies.

    Article  PubMed  Google Scholar 

  5. Bhattacharyya N: Factors predicting survival for cancer of the ethmoid sinus. Am J Rhinol 2002, 16:281–286.

    PubMed  Google Scholar 

  6. Greene FL, Page DL, Fleming ID, et al.: Cancer Staging Handbook, edn 6. New York: Springer-Verlag; 2003. The updated staging system for paranasal sinus malignancies and survival statistics should be understood by every treating physician before discussing treatment options.

    Google Scholar 

  7. Leclerc A: Sinonasal cancer and wood dust exposure: results from a case-control study. Am J Epidemiol 1994, 140:340–349.

    PubMed  CAS  Google Scholar 

  8. Bussi M, Gervasio CF, Riontino E: Study of ethmoidal mucosa in a population at occupational high risk of sinonasal adenocarcinoma. Acta Otolaryngol 2002, 122:197–201.

    Article  PubMed  CAS  Google Scholar 

  9. Gordon IP, Boffetta, Demers PA: A case study comparing a meta-analysis and a pooled analysis of studies of sinonasal cancer among wood workers. Epidemiology 1998, 9:518–24.

    Article  PubMed  CAS  Google Scholar 

  10. Luce D, Leclerc A, Begin D, et al.: Sinonasal cancer and occupational exposures: a pooled analysis of 12 casecontrol studies. Cancer Causes Control 2002, 13:147–157.

    Article  PubMed  Google Scholar 

  11. Van den Oever R: Occupational exposure to dust and sinonasal cancer. An analysis of 386 cases reported to the NCCSF Cancer Registry. Acta Otorhinolaryngol Belg 1996, 50:19–24.

    PubMed  Google Scholar 

  12. Mannetje A, et al.: Sinonasal cancer, occupation, and tobacco smoking in European women and men. Am J Ind Med, 1999, 36:101–107.

    Article  PubMed  Google Scholar 

  13. Myers LL, et al.: Paranasal sinus malignancies: an 18-year single institution experience. Laryngoscope 2002, 112:1964–1969.

    Article  PubMed  Google Scholar 

  14. Bhattacharyya N: Cancer of the nasal cavity: survival and factors influencing prognosis. Arch Otolaryngol Head Neck Surg 2002, 128:1079–1083.

    PubMed  Google Scholar 

  15. Kresnik E, Mikosch P, Gallowitsch HJ, et al.: Evaluation of head and neck cancer with 18F-FDG PET: a comparison with conventional methods. Eur J Nucl Med 2001, 28:816–821.

    Article  PubMed  CAS  Google Scholar 

  16. Helsel JC, Bardales RH, Mukunyadzi P: Fine-needle aspiration biopsy cytology of malignant neoplasms of the sinonasal tract. Cancer 2003, 99:105–112.

    Article  PubMed  Google Scholar 

  17. Perez P, Dominguez O, Gonzalez S, et al.: Ras gene mutations in ethmoid sinus adenocarcinoma: prognostic implications. Cancer 1999, 86:255–264.

    Article  PubMed  CAS  Google Scholar 

  18. Riazimand SH, Brieger J, Jacob R, et al.: Analysis of cytogenetic aberrations in esthesioneuroblastomas by comparative genomic hybridization. Cancer Genet Cytogenet 2002, 136:53–57.

    Article  PubMed  CAS  Google Scholar 

  19. Ariza M, Llorente JL, Alvarez-Marcas C, et al.: Comparative genomic hybridization in primary sinonasal adenocarcinomas. Cancer 2004, 100:335–341.

    Article  PubMed  CAS  Google Scholar 

  20. Martins C, Fonseca I, Roque L, et al.: Cytogenetic similarities between two types of salivary gland carcinomas: adenoid cystic carcinoma and polymorphous low-grade adenocarcinoma. Cancer Genet Cytogenet 2001, 128:130–136.

    Article  PubMed  CAS  Google Scholar 

  21. Myers LL, Oxford LE: Differential diagnosis and treatment options in paranasal sinus cancers. Surg Oncol Clin N Am 2004, 13:167–186. This review provides an excellent overview for the physican in evaluating patients with suspected paranasal sinus cancers.

    Article  PubMed  Google Scholar 

  22. Samant S, Robbins KT, Vang M, et al.: Intra-arterial cisplatin and concomitant radiation therapy followed by surgery for advanced paranasal sinus cancer. Arch Otolaryngol Head Neck Surg 2004, 130:948–955.

    Article  PubMed  Google Scholar 

  23. Rischin D, Porceddu S, Peters L, et al.: Promising results with chemoradiation in patients with sinonasal undifferentiated carcinoma. Head Neck 2004, 26:435–441.

    Article  PubMed  Google Scholar 

  24. Papadimitrakopoulou VA, Hong WK: Combined-modality therapy in paranasal sinus cancer. Cancer J Sci Am 1999, 5:208–210.

    PubMed  CAS  Google Scholar 

  25. Katz TS, Mendenhall WM, Morris CG, et al.: Malignant tumors of the nasal cavity and paranasal sinuses. Head Neck 2002, 24:821–829.

    Article  PubMed  Google Scholar 

  26. Dulguerov P, Jacobsen MS, Allal AS, et al.: Nasal and paranasal sinus carcinoma: are we making progress? A series of 220 patients and a systematic review. Cancer 2001, 92:3012–3029. This retrospective analysis of 220 patients with at least 4-year follow-up and literature review confirms improvement in outcomes in this tumor site. The comprehensive nature of this article from a busy tertiary care academic center provides the oncology specialist with information crucial to future treatment of this disease.

    Article  PubMed  CAS  Google Scholar 

  27. Lee MM, Vokes EE, Rosen A, et al.: Multimodality therapy in advanced paranasal sinus carcinoma: superior long-term results. Cancer J Sci Am 1999, 5:219–223.

    PubMed  CAS  Google Scholar 

  28. Licitra L, Locati LD, Cavina R, et al.: Primary chemotherapy followed by anterior craniofacial resection and radiotherapy for paranasal cancer. Ann Oncol 2003, 14:367–372.

    Article  PubMed  CAS  Google Scholar 

  29. Keles N, Erdamar B, Kaur A, Deger K: p21, p53, and p27, Kip1 alterations in benign and malignant tumors of sinonasal epithelium. Otolaryngol Head Neck Surg 2003, 129:77–84.

    Article  PubMed  Google Scholar 

  30. Pfister DG, Ang K, Brockstein B, et al.: National Comprehensive Cancer Network (NCCN) Practice Guidelines for Head and Neck Cancers. Oncology (Huntingt) 2000, 14:163–194.

    CAS  Google Scholar 

  31. National Comprehensive Cancer Network (NCCN): Practice Guidelines for Head and Neck Cancers. National Comprehensive Cancer Network, 2004. Accessible at http://nccn.org/. Accessed Ocotber 1, 2004.

  32. Suarez C, Llorente JL, Fernandez De Leon R, et al.: Prognostic factors in sinonasal tumors involving the anterior skull base. Head Neck 2004, 26:136–144.

    Article  PubMed  Google Scholar 

  33. Choi HR, Sturgis EM, Rashid A, et al.: Sinonasal adenocarcinoma: evidence for histogenetic divergence of the enteric and nonenteric phenotypes. Hum Pathol 2003, 34:1101–1107.

    Article  PubMed  Google Scholar 

  34. Barnes L: Intestinal-type adenocarcinoma of the nasal cavity and paranasal sinuses. Am J Surg Pathol 1986, 10:192–202.

    Article  PubMed  CAS  Google Scholar 

  35. Kennedy MT, et al.: Expression pattern of CK7, CK20, CDX-2, and villin in intestinal-type sinonasal adenocarcinoma. J Clin Pathol 2004, 57:932–937.

    Article  PubMed  CAS  Google Scholar 

  36. Porceddu S, Martin J, Shanker G, et al.: Paranasal sinus tumors: Peter MacCallum Cancer Institute experience. Head Neck 2004, 26:322–330.

    Article  PubMed  Google Scholar 

  37. Wax MK, Burkey BB, Bascom D, et al.: Adenocarcinoma of the ethmoid sinus. Head Neck 1995, 17:303–311.

    Article  PubMed  CAS  Google Scholar 

  38. Bhattacharyya N: Survival and staging characteristics for nonsquamous cell malignancies of the maxillary sinus. Arch Otolaryngol Head Neck Surg 2003, 129:334–337.

    Article  PubMed  Google Scholar 

  39. Wiseman SM, Rigual NR, Hicks WL Jr, et al.: Adenoid cystic carcinoma of the paranasal sinuses or nasal cavity: a 40-year review of 35 cases. Ear Nose Throat J 2002, 81:510–514.

    PubMed  Google Scholar 

  40. Thompson LD, Wieneke JA, Miettinen M: Sinonasal tract and nasopharyngeal melanomas: a clinicopathologic study of 115 cases with a proposed staging system. Am J Surg Pathol 2003, 27:594–611. Mucosal melanoma of the sinonasal tract has an extremely poor prognosis confirmed in this study which evaluates prognostic factors and provides insight into additional staging related criteria.

    Article  PubMed  Google Scholar 

  41. Dulguerov P, Calcaterra T: Esthesioneuroblastoma: the UCLA experience 1970–1990. Laryngoscope 1992, 102:843–849.

    Article  PubMed  CAS  Google Scholar 

  42. Kadish SM, Goodman, Wang CC: Olfactory neuroblastoma. A clinical analysis of 17 cases. Cancer 1976, 37:1571–1576.

    Article  PubMed  CAS  Google Scholar 

  43. Hyams VJ: Tumors of The Upper Respiratory Tract and Ear. In Atlas of Tumor Pathology. Edited by BJ Hyams, VJ Michaels L. Washington, DC: Armed Forces Institute of Pathology; 1998:240–248.

    Google Scholar 

  44. McElroy EA Jr, Buckner JC, Lewis JE: Chemotherapy for advanced esthesioneuroblastoma: the Mayo Clinic experience. Neurosurgery 1998, 42:1023–1027.

    Article  PubMed  Google Scholar 

  45. Eich HT, Hero B, Staar S, et al.: Multimodality therapy including radiotherapy and chemotherapy improves event-free survival in stage-C esthesioneuroblastoma. Strahlenther Onkol 2003, 179:233–240.

    Article  PubMed  Google Scholar 

  46. Eich HT, Hero B, Staar S, et al.: Esthesioneuroblastoma: irradiation alone and surgery alone are not enough. Int J Radiat Oncol Biol Phys 2002, 54:486–491.

    Article  Google Scholar 

  47. Levine PA, Gallagher R, Cantrell RW: Esthesioneuroblastoma: reflections of a 21-year experience. Laryngoscope 1999, 109:1539–1543. This large series of esthesioneuroblastoma provides the surgeon and oncologist with long-term follow-up and progressive improvement in locoregional control and survival.

    Article  PubMed  CAS  Google Scholar 

  48. Koka VN, Julieron M, Bourhis J, et al.: Aesthesioneuroblastoma. J Laryngol Otol 1998, 112:628–633.

    PubMed  CAS  Google Scholar 

  49. Franchi A, Moroni M, Massi D, et al.: Sinonasal undifferentiated carcinoma, nasopharyngeal-type undifferentiated carcinoma, and keratinizing and nonkeratinizing squamous cell carcinoma express different cytokeratin patterns. Am J Surg Pathol 2002, 26:1597–1604.

    Article  PubMed  Google Scholar 

  50. Jeng YM, Sung MT, Fang CL: Sinonasal undifferentiated carcinoma and nasopharyngeal-type undifferentiated carcinoma: two clinically, biologically, and histopathologically distinct entities. Am J Surg Pathol 2002, 26:371–376.

    Article  PubMed  Google Scholar 

  51. Kim BS, Vongtama R, Juillard G: Sinonasal undifferentiated carcinoma: case series and literature review. Am J Otolaryngol 2004, 25:162–166.

    Article  PubMed  Google Scholar 

  52. Musy PY, Reibel JF, Levine PA: Sinonasal undifferentiated carcinoma: the search for a better outcome. Laryngoscope 2002, 112:1450–1455.

    Article  PubMed  Google Scholar 

  53. Hicks J, Flaitz C: Rhabdomyosarcoma of the head and neck in children. Oral Oncol 2002, 38:450–459.

    Article  PubMed  CAS  Google Scholar 

  54. Shapiro DN, Sublett JE, Li B, et al.: Fusion of PAX3 to a member of the forkhead family of transcription factors in human alveolar rhabdomyosarcoma. Cancer Res 1993, 53:5108–5112.

    PubMed  CAS  Google Scholar 

  55. Scrable HJ, Witte DP, Lampkin BC, Cavenee WK: Chromosomal localization of the human rhabdomyosarcoma locus by mitotic recombination mapping. Nature 1987, 329:645–647.

    Article  PubMed  CAS  Google Scholar 

  56. Raney RB, Asmar L, Vassilopoulou-Sellin R, et al.: Late complications of therapy in 213 children with localized, nonorbital soft-tissue sarcoma of the head and neck: A descriptive report from the Intergroup Rhabdomyosarcoma Studies (IRS)-II and - III. The IRS Group of the Children’s Cancer Group and the Pediatric Oncology Group. Med Pediatr Oncol 1999, 33:362–371. This large series highlights the many late complications related to therapy of children with rhabdomyosarcoma.

    Article  PubMed  CAS  Google Scholar 

  57. Kim GE, Koom WS, Yang WI, et al.: Clinical relevance of three subtypes of primary sinonasal lymphoma characterized by immunophenotypic analysis. Head Neck 2004, 26:584–593.

    Article  PubMed  Google Scholar 

  58. Casanova M, Ferrari A, Gandola L, et al.: Undifferentiated nasopharyngeal carcinoma in children and adolescents: comparison between staging systems. Ann Oncol 2001, 12:1157–1162.

    Article  PubMed  CAS  Google Scholar 

  59. de Alava E, Gerald WL: Molecular biology of the Ewing’s sarcoma/primitive neuroectodermal tumor family. J Clin Oncol 2000, 18:204–213.

    PubMed  Google Scholar 

  60. Cope JU, Tsokos M, Miller RW: Ewing sarcoma and sinonasal neuroectodermal tumors as second malignant tumors after retinoblastoma and other neoplasms. Med Pediatr Oncol 2001, 36:290–294.

    Article  PubMed  CAS  Google Scholar 

  61. Levine PA, Debo RF, Meredith SD, et al.: Craniofacial resection at the University of Virginia (1976–1992): survival analysis. Head Neck 1994, 16:574–577.

    Article  PubMed  CAS  Google Scholar 

  62. Day TA, Davis BK: Skull-base reconstruction and rehabilitation. Otolaryngol Clin North Am 2001, 34:1241–1257.

    Article  PubMed  CAS  Google Scholar 

  63. Teknos TN, Smith JC, Day TA, et al.: Microvascular freetissue transfer in reconstructing skull base defects: lessons learned. Laryngoscope 2002, 112:1871–1876.

    Article  PubMed  Google Scholar 

  64. Osguthorpe JD, Patel S: Craniofacial approaches to sinus malignancy. Otolaryngol Clin North Am 1995, 28:1239–1257.

    PubMed  CAS  Google Scholar 

  65. Raveh J, Turk JB, Ladrach K, et al.: Extended anterior subcranial approach for skull base tumors: long-term results. J Neurosurg 1995, 82:1002–1010.

    Article  PubMed  CAS  Google Scholar 

  66. Moore CE, Ross DA, Marentette LJ: Subcranial approach to tumors of the anterior cranial base: analysis of current and traditional surgical techniques. Otolaryngol Head Neck Surg 1999, 120:387–390.

    Article  PubMed  CAS  Google Scholar 

  67. Jho HD, Ha HG: Endoscopic endonasal skull-base surgery: part 1- the midline anterior fossa skull base. Minim Invasive Neurosurg 2004, 47:1–8.

    Article  PubMed  Google Scholar 

  68. Jho HD, Ha HG: Endoscopic endonasal skull base surgery: part 2- the cavernous sinus. Minim Invasive Neurosurg 2004, 47:9–15.

    Article  PubMed  Google Scholar 

  69. Liu JK, O’Neill B, Orlandi RR, et al.: Endoscopicassisted craniofacial resection of esthesioneuroblastoma: minimizing facial incisions—technical note and report of three cases. Minim Invasive Neurosurg 2003, 46:310–315.

    Article  PubMed  CAS  Google Scholar 

  70. London SD, Schlosser RJ, Gross CW: Endoscopic management of benign sinonasal tumors: a decade of experience. Am J Rhinol 2002, 16:221–227.

    PubMed  Google Scholar 

  71. Devaiah AK, Larsen C, Tawfik O, et al.: Esthesioneuroblastoma: endoscopic nasal and anterior craniotomy resection. Laryngoscope 2003, 113:2086–2090.

    Article  PubMed  Google Scholar 

  72. Walch C, Stammberger H, Anderhuber W, et al.: The minimally invasive approach to olfactory neuroblastoma: combined endoscopic and stereotactic treatment. Laryngoscope 2000, 110:635–640.

    Article  PubMed  CAS  Google Scholar 

  73. Goffart Y, Jorissen M, Daele J, et al.: Minimally invasive endoscopic management of malignant sinonasal tumours. Acta Otorhinolaryngol Belg 2000, 54:221–232.

    PubMed  CAS  Google Scholar 

  74. Polin RS, Sheehan JP, Chenelle AG, et al.: The role of preoperative adjuvant treatment in the management of esthesioneuroblastoma: the University of Virginia experience. Neurosurgery 1998, 42:1029–1037.

    Article  PubMed  CAS  Google Scholar 

  75. Hollinshead WH: Anatomy for Surgeons. In The Head and Neck, edn 3. Philadelphia: JB Lippincott; 1982.

    Google Scholar 

  76. McHam SA, Adelstein DJ, Rybicki LA, et al.: Who merits a neck dissection after definitive chemoradiotherapy for N2-N3 squamous cell head and neck cancer?Head Neck 2003, 25:791–798.

    Article  PubMed  Google Scholar 

  77. Robbins KT, Clayman G, Levine PA, et al.: Neck dissection classification update: revisions proposed by the American Head and Neck Society and the American Academy of Otolaryngology-Head and Neck Surgery. Arch Otolaryngol Head Neck Surg 2002, 128:751–758.

    PubMed  Google Scholar 

  78. Haylock BJ, John DG, Paterson IC: The treatment of squamous cell carcinoma of the paranasal sinuses. Clin Oncol (R Coll Radiol) 1991, 3:17–21.

    CAS  Google Scholar 

  79. Logue JP, Slevin NJ: Carcinoma of the nasal cavity and paranasal sinuses: an analysis of radical radiotherapy. Clin Oncol (R Coll Radiol) 1991, 3:84–89.

    CAS  Google Scholar 

  80. Neal AJ, Habib F, Hope-Stone HF: Carcinoma of the maxillary antrum treated by pre-operative radiotherapy or radical radiotherapy alone. J Laryngol Otol 1992, 106:063–1066.

    Google Scholar 

  81. Waldron JN, O’Sullivan B, Warde P, et al.: Ethmoid sinus cancer: twenty-nine cases managed with primary radiation therapy. Int J Radiat Oncol Biol Phys 1998, 41:361–369.

    Article  PubMed  CAS  Google Scholar 

  82. Tsien C, Eisbruch A, McShan D, et al.: Intensity-modulated radiation therapy (IMRT) for locally advanced paranasal sinus tumors: incorporating clinical decisions in the optimization process. Int J Radiat Oncol Biol Phys 2003, 55:776–784.

    Article  PubMed  Google Scholar 

  83. Prott FJ, Spitz J, Michaelis M, et al.: Results of fast neutron therapy of adenoid cystic carcinoma of the salivary glands. Anticancer Res 2000, 20:3743–3749.

    PubMed  CAS  Google Scholar 

  84. Douglas JG, Koh WJ, Austin-Seymour M, Laramore GE: Treatment of salivary gland neoplasms with fast neutron radiotherapy. Arch Otolaryngol Head Neck Surg 2003, 129:944–948.

    Article  PubMed  Google Scholar 

  85. Douglas JG, Silbergeld DL, Laramore GL: Gamma knife stereotactic radiosurgical boost for patients treated primarily with neutron radiotherapy for salivary gland neoplasms. Stereotact Funct Neurosurg 2004, 82:84–89.

    Article  PubMed  Google Scholar 

  86. Jiang GL, Ang KK, Peters LJ, et al.: Maxillary sinus carcinomas: natural history and results of postoperative radiotherapy. Radiother Oncol 1991, 21:193–200.

    Article  PubMed  CAS  Google Scholar 

  87. Paulino AC, Fisher SG, Marks JE: Is prophylactic neck irradiation indicated in patients with squamous cell carcinoma of the maxillary sinus? Int J Radiat Oncol Biol Phys 1997, 39283–289.

    Article  PubMed  CAS  Google Scholar 

  88. Le QT, Fu KK, Kaplan M, et al.: Treatment of maxillary sinus carcinoma: a comparison of the 1997 and 1977 American Joint Committee on cancer staging systems. Cancer 1999, 86:1700–1711.

    Article  PubMed  CAS  Google Scholar 

  89. Giri SP, Reddy EK, Gemer LS, et al.: Management of advanced squamous cell carcinomas of the maxillary sinus. Cancer 1992, 69:657–661.

    Article  PubMed  CAS  Google Scholar 

  90. Huang D, Xia P, Akazawa P, et al.: Comparison of treatment plans using intensity-modulated radiotherapy and three-dimensional conformal radiotherapy for paranasal sinus carcinoma. Int J Radiat Oncol Biol Phys 2003, 56:158–168.

    Article  PubMed  Google Scholar 

  91. Claus F, De Gersem W, and WagterC, et al.: An implementation strategy for IMRT of ethmoid sinus cancer with bilateral sparing of the optic pathways. Int J Radiat Oncol Biol Phys 2001, 51:318–331.

    Article  PubMed  CAS  Google Scholar 

  92. Mock U, Georg D, Bogner J, et al.: Treatment planning comparison of conventional, 3-D conformal, and intensity-modulated photon (IMRT) and proton therapy for paranasal sinus carcinoma. Int J Radiat Oncol Biol Phys 2004, 58:147–154.

    Article  PubMed  Google Scholar 

  93. Forastiere AA, Goepfert H, Maor M, et al.: Concurrent chemotherapy and radiotherapy for organ preservation in advanced laryngeal cancer. N Engl J Med 2003, 349:2091–2098.

    Article  PubMed  CAS  Google Scholar 

  94. Cooper JS, Pajak TF, Forastiere AA, et al.: Postoperative concurrent radiotherapy and chemotherapy for high-risk squamous-cell carcinoma of the head and neck. N Engl J Med 2004, 350:1937–1944. Valuable data related to postoperative therapy in head and neck cancer including locoregional control and toxicity.

    Article  PubMed  Google Scholar 

  95. Bernier J, Domenge C, Ozsahin M, et al.: Postoperative irradiation with or without concomitant chemotherapy for locally advanced head and neck cancer. N Engl J Med 2004, 350:1945–1952. Valuable data related to postoperative therapy in head and neck cancer including locoregional control and toxicity.

    Article  PubMed  CAS  Google Scholar 

  96. Adelstein DJ, Li Y, Adams GL, et al.: An intergroup phase III comparison of standard radiation therapy and two schedules of concurrent chemoradiotherapy in patients with unresectable squamous cell head and neck cancer. J Clin Oncol 2003, 21:92–98.

    Article  PubMed  Google Scholar 

  97. Adelstein DJ, et al.: Maximizing local control and organ preservation in stage IV squamous cell head and neck cancer with hyperfractionated radiation and concurrent chemotherapy. J Clin Oncol 2002, 20:1405–1410.

    Article  PubMed  Google Scholar 

  98. Rosen A, Vokes EE, Scher N, et al.: Locoregionally advanced paranasal sinus carcinoma. Favorable survival with multimodality therapy. Arch Otolaryngol Head Neck Surg 1993, 119:743–746.

    PubMed  CAS  Google Scholar 

  99. Choi KN, Rotman M, Aziz H, et al.: Concomitant infusion cisplatin and hyperfractionated radiotherapy for locally advanced nasopharyngeal and paranasal sinus tumors. Int J Radiat Oncol Biol Phys 1997, 39:823–829.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Medical University of South Carolina, 96 Jonathan Lucas Street, SC 29425, Charleston, USA

    Terry A. Day MD, FACS

Authors
  1. Terry A. Day MD, FACS
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Ricardo A. Beas MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Rodney J. Schlosser MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Bradford A. Woodworth MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Julio Barredo MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Anand K. Sharma MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. M. Boyd Gillespie MD, FACS
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Day, T.A., Beas, R.A., Schlosser, R.J. et al. Management of paranasal sinus malignancy. Curr. Treat. Options in Oncol. 6, 3–18 (2005). https://doi.org/10.1007/s11864-005-0009-y

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11864-005-0009-y

Keywords

Search

Navigation